Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040425 (
tonsillitis
)
1,594
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Otostegia fruticosa
is traditionally used to treat
tonsillitis
, stomach ache, asthma, arthritis, and febrile illness in different parts of Ethiopia and other countries. In this experiment 70% ethanolic crude extract and fractions of the leaf of
Otostegia fruticosa
(Forssk.) Schweinf. ex Penzig were evaluated for their
in-vivo
anti-inflammatory and analgesic activities and
in-vitro
hyaluronidase
inhibition properties at different concentrations. Tail immersion, acetic acid induced writhing and carrageenan-induced paw edema model were used to assess the
in-vivo
analgesic and anti-inflammatory activities, respectively. Swiss albino mice of either sex were randomly divided into five groups of six mice per group and for evaluation of the fractions randomly divided into six groups of six mice per group. The test groups were treated with hydroalcoholic extract of
Otostegia fruticosa (O. fruticosa)
at doses of 100, 200, and 400 mg/kg. The positive control groups received either pethidine 5 mg/kg or aspirin at 100 mg/kg or 150 mg/kg. The negative control groups were orally given sunflower oil. All the fractions were administered at the dose of 400 mg/kg. In all models, the higher dose (400 mg/kg) of the crude extract and chloroform fraction showed a significant central and peripheral analgesic and anti-inflammatory activities with comparable effects to standards used. The
hyaluronidase
inhibition assay result showed that the test samples displayed concentration-dependent inhibitory activities. These findings indicate that 70% ethanol extract and organic solvent fractions of
O. fruticosa
leaves have potential analgesic, anti-inflammatory, and enzyme inhibitory activities.
...
PMID:Analgesic, Anti-inflammatory and
In-vitro
Hyaluronidase Inhibitory Properties of the Leaf Extract and Solvent Fractions of
Otostegia Fruticosa
(Forssk.) Schweinf. ex Penzig. 3292 82
