Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author describes a 47-year-old patient in whom lingual hemiatrophy developed one month after angina. The development of hemiatrophy was preceded by occipital headaches and pain behind the ear on the side of hemiatrophy. In the differential diagnosis the author excluded inflammatory processes neoplasms and developmental anomalies and thinks that the cause of this short-lasting hemiatrophy might have been tonsillitis with compression of the nerve by the oedematous inflamed tissues with action of bacterial toxins on the nerve.
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PMID:[Short-lived semi-atrophy of the tongue]. 71 30

In 116 children admitted to hospital with tonsillitis of varying types and suspected infectious mononucleosis resp., antibodies, of the IgM class against the EB virus VCA were detected in 27%, a quadruple increase of IgG antibodies in 20% and a negative finding of IgG antibodies also in a second serum sample in 24%. In another group of 51 children admitted with suspected infectious mononucleosis IgM antibodies were found in 47%, a fourfold increase of IgG in 53% and a negative finding of IgG in 10%. In sub-groups of 25 and 30 children resp. from the above groups it was possible to compare the results of specific serology of the EB virus with tests for heterophil antibodies in two serum samples. IgM antibodies were detected in 40% and 50% of children resp., a fourfold rise of IgG in 20% and 67% of children resp., the absence of IgG in 20% and 7% of children resp. Paul-Bunnell reaction was positive in 64% and 60% resp., the OCH-test in 60% and 70% resp., Tomcsik reaction in 16% in the first sub-group and the IM-test in 60% in the second sub-group. In younger children (1-5 years) positive Paul-Bunnell and Tomcsik reactions were less frequent. The IM-test was not positive in any of the children in this age group. An EB-virus aetiology was proved in all types of tonsillitis, least frequently in angina streptococcia (11%), most frequently in angina pseudomembranosa (46%) and mononucleosis infectiosa susp. (54%).
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PMID:[Serologic diagnosis of infectious mononucleosis in children]. 165 51

100 out-patients with subacute or acute stages of pharyngitis, tonsillitis, pharyngotonsillitis or angina participated in a randomized 3 day trial on antiseptic mouth-sprays comparing one containing a combination of chlorhexidine, tramazoline and aluminiumtrilactate with one containing only hexetidine. At the beginning of therapy and 3 days afterwards the local symptoms rubor and tumefaction of the throat, dysphagia, fur, swelling and tenderness of the cervical superficial lymph nodes were classified according to a graded scale. Using the combination these symptoms were markedly improved in 34 patients, improved in 7; 8 showed no alteration and one patient showed a deterioration (n = 50). With the monosubstance 18 patients showed good improvement, 11 an improvement, 17 no change and 3 patients a deterioration (n = 49), one patient needed penicillin-treatment during the trial. Under treatment with the combination the symptoms rubor and tumefaction of the throat showed a significant better improvement. The possible role played by a vasodilator are discussed.
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PMID:[Therapy of acute diseases of the upper airway. Comparison of 2 antiseptic pharyngeal sprays in otorhinolaryngologic practice]. 706 93

Medical records of 876 servicemen of a young age who have suffered various forms of clinical diphtheria were analysed. (Lethal cases were marked in 52 cases--5.9%). A true clinical symptom complex for the diagnosis of diphtheria at pre-hospital period is as following: fever, intoxication and febrinous tonsillitis. The main cause of unfavourable outcome of the disease depends on the affection of cardiovascular, central and peripheral nerve systems by diphtheritic exotoxin. The most frequent limitations during medical care were the following: error diagnosis of angina (41%), late hospitalization and late specific treatment, insufficient doses of antidiphtheric serum, inopportune diagnosis of severe aggravations (infectious toxic shock, pneumonia).
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PMID:[The diagnostic and treatment characteristics of diphtheria in troop units and military medical institutions]. 830 51

The knowledge of the Byzantine physicians in the field of otorhinolaryngology and especially of the eminent ones, Oribasius, Aetius of Ameda, Paul of Aegina and Alexander of Tralles is noteworthy. They knew an adequate number of diseases of the ear, nose and throat and treated them with a plethora of drugs and some of them, especially tonsillitis and tonsillar abscess, with operations. The writer, based on the texts of the Byzantine historians and chroniclers, presents information previously unknown. This includes analysis of cases of an epidemic of angina, speech defects, instances of otitis, epistaxis, ulcer of the mouth, acute laryngitis or pharyngitis and psychogenic aphonia. Most cases concern emperors and other prominent figures of the State and Church. This information complements, from the historical point of view, the scientific knowledge of the medical writers in the field of otorhinolaryngology.
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PMID:Otorhinolaryngological diseases in Byzantium (A.D. 324-1453): information from non-medical literary sources. 897 51

Leukocytic intoxication index (LII) was calculated according to Ya. Ya. Kalf-Kalif formula in 184 patients with tonsillar affections. It grew from follicular and lacunar angina to paratonsillitis and paratonsillar abscesses early in the disease and fell on the treatment day 6. In chronic decompensated tonsillitis before and after tonsillectomy LII was not informative. To predict outcomes in anginas, paratonsillitis and paratonsillar abscesses, follow-up of LII is recommended.
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PMID:[Leukocytic intoxication index in tonsillar diseases]. 1076 19

A 34-year-old female patient with a three year history of generalized granuloma annulare was treated systemically with dapsone (DADPS). Six weeks after the onset of treatment, the patient developed an extensive tonsillitis of the base of the tongue with fever and malaise. Routine laboratory work showed a leukocytopenia with agranulocytosis. Further investigation revealed a marked decrease of the enzyme activity of N-acetyltransferase 2, which plays an important role in dapsone metabolism. Treatment included the cessation of dapsone, antibiotic coverage, and G-CSF leading to the rapid improvement of symptoms and normalization of leukocyte counts. Dapsone-induced angina agranulocytotica is a rare event and is interpreted as an idiosyncratic reaction. Depending on genetic polymorphisms of various enzymes, dapsone can be metabolized to immunologically or toxicologically relevant intermediates. Because of the risk of severe hematologic reactions, dapsone should only be employed for solid indications and with appropriate monitoring.
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PMID:[Dapsone-induced agranulocytosis. The role of xenobiotic-metabolizing enzymes demonstrated by a case report]. 1599 87

The treatment of hyperthyroidism with antithyroid drugs can cause a significant side effect in 0.2 to 0.3% of the cases: agranulocytosis. Infectious complications caused by this condition affect mainly the throat, and tonsillitis is one of its manifestations. The present study reported the case of a female patient, 33 years old, manifesting odynophagia and fever resistant to many antibiotics. The patient showed hyperthyroidism and had been using methimazole for two months. With the diagnoses of agranulocytic angina, the drug was withdrawn and treatment with ciprofloxacin, symptomatic drugs and granulocytic-colony stimulator, besides fluconazol was started. The patient developed satisfactorily, being discharged ten days after the beginning of the treatment. Fifteen days later, total thyroidectomy was carried out. The purpose of this report is to point at the importance of knowing the collateral effects of the drugs, to advise the patients about them and worm the doctors about the necessity of evaluating the patient as a whole, searching for other current diseases and drugs.
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PMID:[Agranulocytosis with tonsillitis associated with methimazole therapy]. 1644 45

Tonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated autoimmune response in psoriasis. Three patients with streptococcal-induced psoriasis underwent tonsillectomy. Using size spectratyping and sequencing of TCR beta-chain variable region gene (TCRBV) rearrangements, we compared the TCR usage of psoriatic skin lesions, blood, tonsils, and tonsillar T cells fractionated according to the expression of the skin address in "cutaneous lymphocyte-associated Ag" (CLA). TCRBV-size spectratype analysis of the blood lymphocytes, tonsils, and the CLA-negative tonsillar T cells revealed largely unselected T cell populations. Instead, TCRBV gene families of the psoriatic lesions and skin-homing CLA-positive tonsillar T cells displayed highly restricted spectratypes. Sequencing of TCRBV cDNA identified various clonal TCRBV rearrangements within the psoriatic lesions that indicated Ag-driven T cell expansion. Several of these clonotypes were also detected within the tonsils and, in one of the patients, within the small subset of CLA-positive tonsillar T cells, suggesting that T cells from the same T cell clones were simultaneously present within skin and tonsillar tissue. Because after tonsillectomy psoriasis cleared in all three patients our observations indicate that T cells may connect psoriatic inflammation to streptococcal angina. They suggest that the chronic streptococcal immune stimulus within the tonsils could act as a source for pathogenic T cells in poststreptococcal disorders, and they may help to explain why eliminating this source with tonsillectomy may improve streptococcal-induced sequelae.
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PMID:Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris. 1670 73

The concurrence of acute coronary syndrome with allergy or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in daily clinical practice. There are several reports associating mast cell activation with acute cardiovascular events in adults. This was first described by Kounis as 'allergic angina syndrome',progressing to 'allergic myocardial infarction'. The main mechanism proposed is the vasospasm of coronary arteries. We present a case of a 28-year-old man who was admitted to our hospital with thoracic pain and dyspnoea. The symptoms recurred after simultaneous use of 1 g amoxicillin/clavulanic acid orally and 1 g ampicillin/sulbactam parenterally for tonsillitis the night before presentation and on the morning of admission.
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PMID:Kounis syndrome secondary to simultaneous oral amoxicillin and parenteral ampicillin use in a young man. 2315 96


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