Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of the present study was to further develop and substantiate classification of chronic tonsillitis with due regard for etiology and pathogenesis of this disease. The author pays special attention to the fact that the toxico-allergic effect of focal infection of palatine tonsils (chronic tonsillitis, CT) is significantly more pronounced than that of focal infections of a different localization. The toxico-allergic manifestations of chronic tonsillitis are not infrequently realized through the associated non-specific infectious local and general complications and catalyze pathogenesis of the concomitant diseases. The classification developed taking into consideration etiology and pathogenesis of CT distinguishes two forms of chronic tonsillitis, viz. simple and toxico-allergic (TAF) CT, the latter being subdivided into two variants differing in the character of manifestations (TAF-1 and TAF-II). The clinical, morphological, and immunological characteristics of either form are described. It is emphasized that the most informative signs and symptoms of CT include the recurrence rate of tonsillitis in the medical history, purulent discharge from the tonsillar crypts apparent upon compression of their anterior surface with a spatula, and toxico-allergic reactions in combination with local signs and tonsillitis in the medical history. The therapeutic strategies for each forms of CT are specifies. The use of conservative therapy is recommended as the principal method for the treatment of the simple form, the strict compliance with the prescribed therapeutic modalities and repetition of the second therapeutic course within 3-4 months after the initial one being of primary importance. The treatment of TAF-1 should be started from conservative therapy the duration of which needs to be reduced in the absence of the marked desired effect bearing in mind the possibility of development of local and systemic complications. TAF-II requires urgent tonsillectomy because this condition is fraught with immediate severe complications.
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PMID:[Classification and therapeutic strategy for chronic tonsillitis]. 2388 66

The objective of the present study was to undertake the statistical analysis of the methods employed to treat tonsillitis in the children with a view to optimizing adequate dispensary observation, planned conservative therapy and surgical treatment of the patients presenting with chronic tonsillitis. The analysis of the excerpts from the annual reports presented by the head of the otorhinolaryngological department of the Children's City Clinical Hospital No 9 involved the patients admitted for the pre-planned and urgent treatment of paratonsillar abscess between 1990 and 2010. It was shown that the number of children with paratonsillar abscess increased during this period from 5.8 to 12.0%. At the same time, the number of such patients undergoing surgery for the treatment of toxico-allergic forms (TAF-I and TAF-II) decreased from 26.7 to 8.7-11.6% of their total number admitted to the department for the treatment of pharyngeal pathology. These diseases developed in the children frequently ill with chronic tonsillitis after its recurrent exacerbations. Importantly, all these children were registered in the dispensaries of district out-patient clinics at the places of residence and repeatedly underwent courses of conservative therapy of chronic tonsillitis that either resulted in the temporary improvement of their health conditions or produced no effect whatever. Nevertheless, no district otorhinolaryngologist recommended tonsillectomy to a child with chronic tonsillitis. It is concluded that adequate regular medical check-ups in combination with the planned courses of conservative treatment and hospitalization of the patients in due time for the surgical treatment (tonsillectomy) permit to reduce the frequency of complications of such an insidious disease as chronic tonsillitis.
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PMID:[Conservative therapy and surgical treatment of chronic tonsillitis in the children]. 2400 67