Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040425 (
tonsillitis
)
1,594
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heliotropium bacciferum
(Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it is traditionally used for skin diseases and
tonsillitis
. Herein, we report the isolation and characterization of sixteen secondary metabolites from the aerial part extracts. They include a sterol (
1
), megastigman type nor-isoprenoids (
2
,
3
,
4
,
6
,
8
,
10
), C-11 terpene lactones (
5
and
9
), and a monoterpene (
7
) from the chloroform extract (HB-C); monoterpene glucoside (
14
), and phenolic compounds (
11
-
13
,
15
,
16
) from the methanol one (HB-M). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, and ESIMS analysis. HB-M showed a significant and concentration dependent scavenging activity
in vitro
against the radicals DPPH and ABTS
,
related to the phenol derivatives (
11
-
13,
and
15
-
16
), and HB-C inhibited the growth of
colon cancer
cell lines, mainly for the presence of the antiproliferative C-11 terpene lactones (
5
and
9
).
...
PMID:
Heliotropium bacciferum
Forssk. (Boraginaceae) extracts: chemical constituents, antioxidant activity and cytotoxic effect in human cancer cell lines. 2943 Sep 49
