Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Equal efficiency was proved by comparing two inactivated vaccines against Aujeszky's disease (AD) virus manufactured in Czechoslovakia. Fifteen porkers at the age of four weeks were included in the experiment, not possessing any specific antibodies to AD virus. Each vaccine was inoculated intramuscularly to five porkers (2 ml) in the interval of three weeks. The third group of five porkers was control. The samples of blood serum were subjected to the serum neutralizing test and radioimmunoassay (RIA) 21 and 35 days after vaccination. Three weeks after vaccination, antibody titers were demonstrated in nine from ten vaccinated porkers by RIA, in one pig by SNT. All 15 porkers were challenged with live virulent strain of the virus on the 35th day after the start of the experiment. The ten vaccinated porkers survived the infection after a short feverish disorder. Out of the five unvaccinated controls four pigs died; the patho-anatomic findings demonstrated necrotic tonsillitis and lobar bronchopneumonia. The finding in the fifth control porker was identical; the porker was killed 15 days after infection.
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PMID:[Comparison of 2 inactivated vaccines against Aujeszky's disease in pigs]. 626 63

All of the eight 5-day-old pigs orally given pseudorabies (Aujeszky's disease) virus developed tonsillitis. The initial changes occurred in the subepithelial area between the lymphoid nodule and the crypt epithelium, showing a characteristic pattern of necrosis. The necrosis became more severe and gained access into the lymphoid nodule and crypt epithelium. Coincident with the histopathologic changes, numerous specific immunofluorescences were detected, first in the nucleus and in some parts of the cytoplasm of cells distributed in the subepithelial area. The fluorescence subsequently spread into adjacent lymphoid nodules and crypt epithelial cells. Ultrastructurally, many enveloped virus particles were detected in the center of the necrosis. Thereafter, the crypt epithelial cells also underwent degeneration, and a small number of virus particles were detected in the nucleus of the degenerating epithelial cells. In the more advanced stage, the enveloped virus particles were discharged into the crypt lumen.
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PMID:Tonsillar changes in pigs given pseudorabies (Aujeszky's disease) virus. 637 49