Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two young men with streptococcal tonsillitis had acute myopericarditis mimicking myocardial infarction. Subsequently, 264 consecutive army conscripts hospitalized with a fever and sore throat underwent throat cultures. Group A streptococci were found in 84 patients. When these patients were systematically screened by serial electrocardiography for myocarditis, one case of probable asymptomatic myocarditis was diagnosed. None had signs of acute rheumatic fever. All three patients received penicillin therapy when the signs of myocarditis appeared. Their recovery was good.
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PMID:Streptococcal tonsillitis and acute nonrheumatic myopericarditis. 264 89

Two weeks following streptococcal tonsillitis two patients developed migratory arthralgia, fever and pericarditic chest pain, followed by an episode of severe coronary retrosternal pressure. The ECG during the latter episodes revealed ST elevation in the inferior wall leads, followed later by the appearance of pathological Q waves in the same leads which persisted for only a few days. Radionuclide scans and echocardiographic studies revealed localized involvement of the inferior left ventricle in both cases and, in addition, involvement of the right ventricle in have been suggested to explain the co-occurrence of viral myopericarditis and myocardial infarction (MI)-like picture during acute rheumatic fever can be explained either by coronary vasculitis resulting in myocardial ischemia, or by direct involvement of the myocardium because of an inflammatory process. Both mechanisms have been suggested to explain the co-occurrence of viral myopericarditis and myocardial necrosis. The transient Q waves were probably produced by stunning of the myocytes during the acute phase of the disease. Increased awareness will probably result in detection of similar cases and may contribute to understanding the pathogenesis of the MI-like picture of acute rheumatic fever.
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PMID:Rheumatic carditis presenting as acute myocardial infarction. 401 30

The concurrence of acute coronary syndrome with allergy or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in daily clinical practice. There are several reports associating mast cell activation with acute cardiovascular events in adults. This was first described by Kounis as 'allergic angina syndrome',progressing to 'allergic myocardial infarction'. The main mechanism proposed is the vasospasm of coronary arteries. We present a case of a 28-year-old man who was admitted to our hospital with thoracic pain and dyspnoea. The symptoms recurred after simultaneous use of 1 g amoxicillin/clavulanic acid orally and 1 g ampicillin/sulbactam parenterally for tonsillitis the night before presentation and on the morning of admission.
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PMID:Kounis syndrome secondary to simultaneous oral amoxicillin and parenteral ampicillin use in a young man. 2315 96

Kounis syndrome refers to the concurrence of acute coronary events and allergic or hypersensitivity reactions. In this report, we describe the case of a male patient, in whom acute ST-segment elevation and myocardial infarction developed immediately after injection of depot penicillin, and we discuss the Kounis syndrome. A 52-year-old male patient had chest pain, hypotension and ST-elevation on leads DI and aVL of electrocardiography 30 minutes after intramuscular penicillin injection due to cryptic tonsillitis. Kounis syndrome was considered as a possible diagnosis according to the presentation. Histamine and tryptase levels were not studied due to the delay on arrival to the emergency department. The patient promptly underwent coronary angiography, which revealed only diffuse plaques in all main coronary arteries without any obstructive lesion. We found only increased immunoglobulin (Ig) E, which is associated with the syndrome. With this report, we remind clinicians to consider Kounis syndrome in patients who are subjected to allergenic substances and demonstrate acute chest pain.
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PMID:[A case of acute coronary syndrome following the use of parenteral penicillin: Kounis syndrome]. 2336 46