Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 28 year old female patient with Cushing's syndrome due to an adrenal adenoma also suffered from recurrent urinary infections (proteus), tonsillitis (streptococcus), permanent candidiasis and perimandibular abscess (Staphylococcus pyogenes). Suppression of cellular and humoral immunity was confirmed by in vitro tests. After successful right adrenalectomy the clinical signs of Cushing's syndrome disappeared and no evidence of either bacterial or fungal infection were noted one year postoperatively. Immunological tests showed the restitution of both cellular and humoral immunity. The course of the disease in the patient supports the idea that Cushing's syndrome might be considered as a transitory immune deficiency state.
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PMID:Cushing's syndrome--transitory immune deficiency state? 374 30

The global epidemic of HIV infection remains appalling. By 2001, there were an estimated 1.4 million HIV-infected children, with 4.5 million deaths. In the UK, paediatric cases are clustered around population centres where there are high concentrations of infected immigrant adults, and to a lesser extent, areas where IV drug abuse is common. The highest incidence remains in London and the southeast. With the national redistribution of immigrant and refugee families, any doctor in any specialty may expect to be involved with children who are HIV positive, or have clinical AIDS. The majority of children are infected vertically, i.e. infection of the infant from an infected mother in the pre-, peri-, or post-natal periods. Rates of transmission vary from 15-20% in the developed countries. Children with HIV infection may have their primary presentation to ENT doctors, who should have appropriate thresholds for suspecting the diagnosis. The most common presenting features include persistent generalised lymphadenopathy, hepatosplenomegaly, chronic/recurrent diarrhoea, poor growth, and fever. Fifteen to twenty percent of untreated children will present with an AIDS-defining illness by 12 months, typically with Pneumocystis pneumonia at approximately 3-4 months of age. Seventy percent of perinatally infected children will exhibit some signs or symptoms by 12 months Without treatment, the median age to progression to AIDS is approximately 6 years, and 25-30% will have died by this age. The median age of death is approximately 9 years. Children may also present with repeated/unusual ear infections, sinus disease (inc. mastoiditis), tonsillitis, orbital/peri-orbital cellulitis, oral candidiasis, and dental infections. Infections with streptococcus pneumoniae and group A streptococcus are common, and often progress to severe systemic infection with an appreciable mortality. Infections may be due to unusual pathogens such as Pseudomonas, 'typical' and atypical Mycobacteria, Candida, Aspergillus, etc. Fungal infections of the sinuses (inc. Aspergillus and Rhizopus spp.) may be particularly devastating, with rapid spread to involve bone and the central nervous system. Another classical presentation, which may present to ENT doctors, is that of bilateral parotid enlargement, especially in children who are 'slow progressors', many of whom also have Lymphoid Interstitial Pneumonitis (LIP). A major attitudinal change has occurred due to advances in 3 main areas: (i) the multidisciplinary management of the infected mother (inc. counselling, antenatal screening, elective caesarean section, advising against breast feeding, etc.), (ii) the prevention of vertical transmission, using anti-retroviral therapy to the infected mother during pregnancy, and to the potentially infected infant in the first weeks of life, and (iii) major advances due to the advent of highly active anti-retroviral treatment. With effective use of these measures, transmission rates may be reduced to <2%. None of the measures though, affect a cure, and it will still be many years before the development of effective vaccines. ENT doctors may be referred children already known to be HIV-positive. Knowing how to talk to infected children (and their parents) is full of potential pitfalls, and requires careful forethought. Many infection-control policies have required considerable rethinking due to the AIDS epidemic. This has especially been the case with respect to needle-stick injuries, post-exposure prophylaxis, sterilization and re-use of equipment, and safe approaches to surgery.
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PMID:HIV infection in children--impact upon ENT doctors. 1466 74

Geotrichum candidum was cultured from the tonsils of a free-ranging weaner pig that was presented with lethargy and inappetence. Histopathology indicated pyogranulomatous tonsillitis with intralesional fungal hyphae and arthrospores. Geotrichosis is a rare, opportunistic mycosis of immunocompromised hosts, usually human beings.
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PMID:Tonsillitis in a weaner pig associated with Geotrichum candidum. 2121 55

The prevalence of mycosis affecting ears, nose, and throat was analysed based on the literature data and the results of original observations of 3964 patients who applied for medical aid to the counseling department of our centre during the period from 2005 to 2007. The study revealed a relative increase in the occurrence of ear, nose, and throat mycosis in the structure of chronic inflammatory pathology. Specifically, the frequency of mycotic otitis rose to 25.2%, mycotic infestation of the pharynx in patients with pharyngitis and tonsillitis to 28.7%, mycotic infestation of the larynx associated with chronic laryngitis to 20%, and mycosis in patients presenting with chronic inflammation of the nasal cavity or paranasal sinuses to 7%. The spectrum of pathogenic fungi affecting ears, nose, and throat has been identified. The enhanced contribution of various non-albicans Candida strains to the development of chronic inflammation is documented. Aspergillus species are shown to play the increasingly more important role in the affection of palatal tonsils, laryngeal and pharyngeal mucosa.
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PMID:[Selected aspects of modern epidemiology of ENT-mycoses]. 2151 77

The analysis of the prevalence of mycoses based on the literature data and original observations gives evidence of the increase in the relative frequency of mycotic lesions in the overall ENT morbidity. The occurrence of otomycosis among otitides of different etiology is estimated at 25% and that of pharyngomycosis in the patients presenting with chronic pharygitis and tonsillitis up to 28%. The mycotic lesions in the larynx are diagnosed in almost 15% of the patients with chronic laryngitis. Chronic inflammation of intranasal cavity and paranasal sinuses is associated with mycosis in 7% of the patients. The factors that promote the development of mycotic lesions are considered and specific clinical manifestations described with special reference to their localization and taxonomical identification of the fungi. The optimal approaches to the diagnostics and treatment of ENT mycosis are discussed. The strategies of local and general antimycotic therapy are proposed with the use of modern antimycotic agents taking into account peculiarities of the clinical course of the disease, indications and contraindications for their application.
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PMID:[The modern approach to diagnostics and treatment of mycotic lesions in ear, nose, and throat]. 2326 56