Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040425 (tonsillitis)
 1,594 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Rosai-Dorfman syndrome is a benign disease, one of its commonest affected sites being the cervical lymph nodes. This disease should be considered in the differential diagnosis of a cervical lymphadenopathy. The syndrome often begins with a chronic rhinitis, and is accompanied by sinusitis, tonsillitis or pharyngitis; blood tests indicate chronic infection. The pathogenesis of the disease is still unknown but may include infection or an abnormal autoimmune reaction. The diagnosis is established by the findings of characteristic histiocytes with haemophagocytosis. We report a female patient with persistent cervical lymph node swelling resistant to treatment. The cause was proved by histology to be a Rosai-Dorfman syndrome.
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PMID:[Rosai-Dorfman syndrome. On the differential diagnosis of lymph node swelling]. 156 88

Pharmacokinetic , bacteriological and clinical studies on norfloxacin (NFLX), a quinolone-carboxylic acid antibacterial agent, were conducted in the pediatric field. 1. Serum concentrations and urinary excretion of NFLX after single dose of 2.2 approximately 5.6 mg/kg (mean 4.4 +/- 1.2 mg/kg) were determined in 13 children with ages between 6 and 11 years. The mean peak serum concentration of the drug was 0.37 +/- 0.20 micrograms/ml at 2 hours after administration. The mean half-life of the drug in serum was 2.8 +/- 0.4 hours and the serum concentration at 8 hours was 0.11 +/- 0.06 micrograms/ml. The mean urinary concentration reached a maximum of 125.2 +2- 166.2 micrograms/ml in pooled urine from 0 to 2 hours and the mean urinary recovery rate in the first 8 hours after administration was 22.1 +/- 6.0%. A dose-response relationship was observed between doses/body weight and peak serum concentrations. 2. The clinical efficacy, bacteriological efficacy and the safety of NFLX were evaluated in 65 pediatric patients with ages between 2 years 10 months and 15 years 7 months with infections. In 62 assessable cases (acute purulent tonsillitis 9 cases, acute pneumonia 3 cases, chronic rhinitis 1 case, urinary tract infections 15 cases, and acute colitis 34 cases), clinical efficacies were excellent in 48 cases, good in 13 cases, and fair in 1 case with an overall efficacy rate of 98.4%. Staphylococcus aureus 1 strain, Staphylococcus epidermidis 1 strain, Escherichia coli 10 strains, Salmonella sp. 5 strains, Morganella morganii 1 strain, Pseudomonas aeruginosa 3 strains, Haemophilus parainfluenzae 1 strain and Campylobacter jejuni 12 strains were isolated from the patients as pathogens. Bacteriologically, all of these strains were eradicated except that 3 strains of C. jejuni only decreased. With regard to side effects, dizziness and nausea were observed in 1 case each but they were slight and the continuation of the treatment was possible. No abnormal laboratory test data were observed. From the above results, NFLX was considered to be a useful drug for the treatment of pediatric infections.
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PMID:[Basic and clinical studies on norfloxacin in the pediatric field]. 226 68

An epidemiological survey of randomly selected school children led to Abidjan in three public schools made it possible to determine the prevalence of the rhinopharyngeal diseases in presence of malocclusions. It is an exploratory study jointly undertaken by two teams of specialists in ORL and Orthodontics within a sample of African schoolchildren old of 5 to 21 years. The results showed the presence of malocclusions in 73.30% of the cases (N = 220). The rhinopharyngeal diseases account for 38.3% (N = 115). At the subjects carrying a malocclusion the rhinopharyngeal diseases are 48.30% and they are dominated by the allergic chronic rhinitis (40%) followed obstructive hypertrophic tonsillitis (16.5%). However, these states which cause certainly a nasal obstruction involving an oral breathing do not cause inevitably malocclusion. We cannot thus affirm unambiguous a bond between malocclusions and rhinopharyngeal diseases (p > 0.05). They are nevertheless as many indications to question the patient on other symptoms and to refer to an ORL specialist. Our investigation being limited to the occlusal study, it seems essential to us to continue these analyses to detect the possible predisposition of certain patients to develop dento-skeletal anomalies in the presence of rhinopharyngic diseases.
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PMID:[Prevalence of rhino-pharyngeal disease in the presence of malocclusion in school children in the village of Abidjan]. 1624 63

Incidence and predominant causes of deafness in 20 neonates, 100 infants and 1340 school going population in the northern region of the Indian subcontinent, was investigated by the E. N. T. Department, of Dayanand Medical college and Hospital, Ludhiana, Punjab.The recorded incidence of deafness in school going children was 12.16% comprising conductive loss (98%) and S. N. loss 2%. Out of many cases more notable were chronic rhinitis, tonsillitis, adenoiditis etc.
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PMID:Deafness in paediatric age group. 2311 36