Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0039730 (thalassemia)
 10,305 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hemoglobin 2392
beta-globin 1022
ferritin 721
Sep 615
erythroid 549
Mol 408
HBB 303
gamma-globin 197
transferrin 187
HLA 180
beta globin 164
melanin-concentrating hormone 164
erythropoietin 157
alpha globin 141
endonuclease 134
methemoglobin 124
HBA2 118
X-linked 115
I-1 111
alpha-chain 101
ATRX 99
BCL11A 93
MRI 87
hemochromatosis 79
glucose-6-phosphate dehydrogenase 78
transferrin receptor 77
She 76
insulin 72
HBA1 71
delta-globin 70
CD34 65
ATR 60
MED 59
hereditary hemochromatosis 56
gamma globin 52
AAG 49
cryptic 49
ARMS 46
gamma chain 46
cystatin C 44
Hepcidin 43
histone 43
alkaline phosphatase 42
HBG2 40
polypeptide 39
HBD 39
thrombin 38
MYB 38
growth hormone 37
HFE 36
human leukocyte antigen 34
HBS1L 34
lactate dehydrogenase 33
cytokine 33
GTG 33
Ferritin 32
B12 32
prothrombin 31
collagen 31
aspartate aminotransferase 30
GSH 30
UTR 30
catalase 30
ATP 29
protein C 28
alanine aminotransferase 28
B19 27
interferon 26
DAXX 26
superoxide dismutase 25
G6PD 25
Rad 25
KLF1 25
telomeric 25
ATRX protein 24
ABO 24
glutathione peroxidase 24
p53 23
alpha 4 23
albumin 23
beta globin chain 23
pyruvate kinase 23
osteocalcin 23
kit 22
membrane protein 22
pseudoxanthoma elasticum 22
haptoglobin 21
CD8 21
CD4 21
SCD 21
parathyroid hormone 20
GATA-1 20
SDS 20
HBG1 20
HS2 20
lymphoid 19
mutant beta-globin 19
histone deacetylase 19
TGA 19
fibrinogen 19
delta globin 19
SCT 19
zinc finger 19
surface antigen 19
membrane-bound 18
Polymerase 18
C-reactive protein 18
SNF2 17
ATPase 17
ACG 16
glutathione reductase 16
hematopoietic stem and progenitor cells 16
helicase 16
IgA 16
antithrombin III 16
Erythropoietin 16
HDL 16
annexin V 16
protein S 15
chronic renal failure 15
tumor necrosis factor 15
GGT 15
NMR 14
DNase I 14
FSH 14
alpha, beta 14
HBA 14
CD41 14
GATA1 14
CAC 14
ankyrin 14
HAMP 14
Met 13
DNA polymerase 13
TAT 13
A-I 13
SWI 13
telomerase reverse transcriptase 13
XNP 13
BMD 13
CAR 12
isocitrate dehydrogenase 12
methyltransferase 12
EKLF 12
TRH 12
serum albumin 12
factor VIII 12
Duffy 12
theta-1 12
factor V Leiden 12
HLA-A 12
AST 12
IL-6 12
IDH1 12
gut 12
interleukin-6 12
p38 12
X-linked) 12
P50 11
JAK2 11
more...
Disease
thalassemia 10305
sickle cell disease 1474
anemia 1365
iron overload 1012
hemoglobinopathies 948
thalassemia major 913
beta thalassemia 435
HBB 303
HBB 303
HBB 303
hemolytic anemia 302
iron deficiency 297
malaria 291
thalassemia trait 256
cancer 223
diabetes 191
mental retardation 166
mental retardation 164
alpha thalassemia 160
iron deficiency anemia 154
graft-versus-host disease 152
microcytic anemia 145
osteoporosis 130
hemochromatosis 128
hereditary persistence of fetal hemoglobin 127
myelodysplastic syndrome 124
G6PD deficiency 122
hepatitis C 119
heart failure 117
genetic disorder 112
thalassemia minor 111
hereditary spherocytosis 111
pulmonary hypertension 108
stroke 108
leukemia 104
West 100
ATRX 99
hepatitis B 95
hemosiderosis 89
cirrhosis 85
HIV 85
tumor 83
aplastic anemia 82
cystic fibrosis 82
hypothyroidism 81
blood disorder 75
sepsis 74
hypogonadism 74
hypochromic anemia 71
HPFH 70
hepatitis 69
abortion 68
cardiomyopathy 67
haemophilia 67
siderosis 64
infectious diseases 64
hereditary hemochromatosis 64
gallstones 64
thrombocytopenia 60
acute chest syndrome 58
spinal cord compression 57
hypertension 55
immunodeficiency 55
leg ulcers 54
sepsis 54
hypersplenism 49
chronic hepatitis 49
heart disease 48
hepatocellular carcinoma 46
Down syndrome 45
chronic myeloid leukemia 43
AIDS 42
bone disease 40
hypoparathyroidism 40
HBD 39
erythrocytosis 39
CAA 38
syndrome X 38
CAA 38
liver disease 38
congestive heart failure 37
Thalassemia intermedia 37
thrombocytosis 36
agranulocytosis 36
erythroleukemia 36
acute myeloid leukemia 35
lymphoma 35
parvovirus 35
myelofibrosis 33
neutropenia 33
Best 32
DBA 32
depression 31
renal disease 31
GSH 30
virus infection 30
pseudoxanthoma elasticum 29
Hodgkin's disease 29
anemia of chronic disease 29
osteomyelitis 28
delayed puberty 28
acute lymphoblastic leukemia 28
multiple myeloma 27
ischemia 27
hyperbilirubinemia 26
priapism 26
Fanconi 26
autoimmune hemolytic anemia 26
liver fibrosis 25
chronic liver disease 25
viral hepatitis 25
cytomegalovirus 25
malnutrition 24
atherosclerosis 24
idiopathic thrombocytopenic purpura 24
polycythemia vera 24
congenital hemolytic anemia 24
hereditary elliptocytosis 24
Plasmodium falciparum malaria 24
renal failure 23
pneumonia 23
chronic disease 23
phenylketonuria 23
glucose intolerance 23
asthma 23
hypogonadotropic hypogonadism 22
myeloproliferative disorders 22
paroxysmal nocturnal hemoglobinuria 22
Infection 22
arthritis 22
SCD 21
Gaucher disease 21
retinopathy 21
cold 20
SDS 20
hereditary anemia 20
glioma 20
Duchenne muscular dystrophy 20
proteinuria 20
SCT 19
dehydration 19
Haemophilia 19
pyruvate kinase deficiency 19
Wilson's disease 18
rash 18
Yersinia 18
Wiskott-Aldrich syndrome 18
dyserythropoietic anemia 18
systemic lupus erythematosus 17
chronic renal failure 17
carcinoma 17
infertility 17
immune deficiency 17
Gilbert 17
malabsorption 16
megaloblastic anemia 16
folate deficiency 16
BMD 16
tuberculosis 16
hematologic malignancies 16
more...
Symptom
splenomegaly 227
pain 101
hepatosplenomegaly 51
hepatomegaly 45
pallor 34
headache 26
seizures 24
paraparesis 22
diarrhea 21
dyspnea 19
fatigue 19
anesthesia 18
nausea 17
abdominal pain 17
arthralgia 16
back pain 16
weakness 15
vomiting 13
thinning 12
bone pain 11
discomfort 9
discomfort 9
acute pain 8
chest pain 8
exhaustion 7
anorexia 7
dizziness 7
respiratory distress 7
stigma 7
shortness of breath 7
cyanosis 6
asthenia 6
numbness 5
Ill 5
analgesia 5
myalgia 5
chills 5
lethargy 5
angina 4
regurgitation 4
collapse 4
overweight 4
low back pain 4
epigastric pain 4
cough 3
left upper quadrant pain 3
syncope 3
paresthesia 3
ataxia 3
muscle rigidity 3
erythema 3
hypothermia 3
Reticulocytosis 3
wheezing 3
acute abdomen 3
exertional dyspnea 3
leg pain 3
No adverse effect 2
acute stress 2
tremor 2
memory loss 2
fever of unknown origin 2
tingling 2
masculinization 2
hypoproteinemia 2
abdominal discomfort 2
non-productive cough 2
hypotonia 2
cardiovascular impairment 2
stomach pain 2
snoring 2
physical appearance 1
tense 1
generalized pain 1
constipation 1
Decreased activity 1
starvation 1
chronic cough 1
sleepiness 1
dysarthria 1
myoclonus 1
despair 1
tinnitus 1
dysuria 1
emaciation 1
tonic-clonic seizure 1
bitter taste 1
Fluctuation 1
enuresis 1
ankle pain 1
polyuria 1
acidity 1
sore throat 1
flank pain 1
disturbed balance 1
flushing 1
Cutaneous anergy 1
hyperoxia 1
Opposition 1
hemoptysis 1
chest tightness 1
lumbar back pain 1
atypical chest pain 1
breath holding 1
hunger 1
hypercapnia 1
nausea and vomiting 1
labored breathing 1
cachexia 1
decreased appetite 1
Organ failure 1
dry skin 1
Scratch 1
ENT 1
spasticity 1
eds 1
apathy 1
Welt 1
Gastrointestinal symptoms 1
Drug
Deferasirox 60
vitamin E 34
lysine 30
Asn 27
ascorbate 27
VCR 25
Cardiovasc 19
Dermatol 18
AGG 16
DNase I 14
Heme 13
TAT 13
G-CSF 10
Desferal 10
Gel 9
Desferal 8
ROS 8
Growth hormone 7
Phosphatidylserine 7
TRM 7
FAD 7
Leaf 6
G418 6
Growth hormone 6
ROC 6
CSF 5
Fluorescein 5
Kenyan 5
Zoledronic acid 5
PTH 5
Mutagen 5
Vitamin E 5
IFN-gamma 5
Cellulose acetate 5
TAC 4
CTX 4
Fluorescein 4
NAG 4
THF 4
MDS 4
Zoledronic acid 4
Dakar 4
Hakka 4
DFP 4
Epoetin alfa 4
NADH 4
Asthma 3
pyridoxal phosphate 3
Nitric Oxide 3
Nephron 3
Biopolymers 3
Luteinizing 3
Activin 3
Fludarabine 3
Denosumab 3
Nephron 3
Glutathione 3
ACT 3
Colombo 2
AZT 2
Alanine 2
Bayer 2
MRC 2
Antithrombin III 2
Sodium phenylbutyrate 2
PFA 2
Campath 2
Deferoxamine mesylate 2
CTC 2
Campath 2
ampicillin 2
Monit 2
Portal 2
CET 2
AZT 2
HCG 2
niacin 2
Vitamin B12 2
TES 2
IL-2 2
CTC 2
PTC 2
Doxycycline 1
Fentanyl 1
Sonata 1
Glucose-6-Phosphate 1
DBS 1
Fragment 1
Emodin 1
Pyridoxal 1
CAM 1
Piracetam 1
DDAVP 1
CFT 1
Fansidar 1
Taxol 1
Emodin 1
nitroglycerin 1
ABC 1
BTC 1
Zmax 1
Ganciclovir 1
CoCl2 1
Silica 1
Epoetin alfa 1
CoCl2 1
Adenosine triphosphate 1
Clodronate 1
citric acid 1
CTM 1
BH4 1
Compound 9 1
Ferrous sulfate 1
lactose 1
ZnCl2 1
Dial 1
Vorinostat 1
Cobalamin 1
ZnCl2 1
Sodium thiosulfate 1
Trib 1
ENT 1
DDAVP 1
EPI 1
Azithromycin 1
Finasteride 1
TTC 1
Ipriflavone 1
THA 1
Daclizumab 1
Itraconazole 1
CTM 1
Vitamin B 1
Lariam 1
Rituximab 1
Ouabain 1
Orphan 1
Albumin 1
SBT 1
IL-11 1
Prednisone 1
ADR 1
CaCl2 1
Gelatin 1
CaCl2 1
Camp 1
Methylhydrazine 1
CaCl2 1
PMPA 1
Epoetin 1
CTT 1
Atarax 1
Fansidar 1
Indomethacin 1
Tenofovir disoproxil fumarate 1
Benserazide 1
Enzyme
ERK 203
endonuclease 134
glucose-6-phosphate dehydrogenase 86
alanine aminotransferase 65
aspartate aminotransferase 45
alkaline phosphatase 42
thrombin 36
catalase 35
lactate dehydrogenase 34
APC 33
BMT 32
superoxide dismutase 30
glutathione peroxidase 24
pyruvate kinase 23
gamma-glutamyl transpeptidase 19
focal adhesion kinase 19
DNA polymerase 18
ATPase 17
peroxidase 17
RNA polymerase 16
glutathione reductase 16
protein kinase 14
TAT 13
mitogen-activated protein kinase 12
isocitrate dehydrogenase 12
AST 12
isocitrate dehydrogenase 12
reverse transcriptase 12
luciferase 11
thromboplastin 10
arginase 10
S1 nuclease 10
trypsin 10
UDP-glucuronosyltransferase 9
DNA methyltransferase 8
methylenetetrahydrofolate reductase 7
methylenetetrahydrofolate reductase 7
NO synthase 7
transcriptase 6
thymidine kinase 6
peroxiredoxin 6
carbonic anhydrase 6
acid phosphatase 6
DNA ligase 6
DNA ligase 6
PKG 5
caspase-3 5
RNase 5
RNase 5
MCS 5
heme oxygenase 5
protein kinase C 4
glutathione S-transferase 4
calcineurin 4
renin 4
AMP-activated protein kinase 4
tissue plasminogen activator 4
hexokinase 4
ceruloplasmin 4
xanthine oxidase 4
ACE 4
adenosine deaminase 4
adenosine deaminase 4
glucocerebrosidase 4
TdT 4
proteasome 4
ribonuclease 3
5'-nucleotidase 3
AMPK 3
ALA synthase 3
GCA 3
ribonuclease 3
phosphofructokinase 3
ACS 3
glyceraldehyde-3-phosphate dehydrogenase 3
aldehyde dehydrogenase 3
phospholipase A2 3
phosphoglycerate kinase 3
matriptase 3
paraoxonase 3
creatine kinase 3
CGT 3
lipase 3
matriptase 3
lipoprotein lipase 3
paraoxonase 3
TGT 3
elastase 3
phenylalanine hydroxylase 3
AMPK 3
beta-galactosidase 3
cathepsin K 2
cdc2 2
STR 2
chitinase 2
AMP-activated kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
GLO 2
gamma-glutamylcysteine synthetase 2
acetylcholinesterase 2
MEK 2
plasmin 2
phosphoglucose isomerase 2
cytochrome oxidase 2
glyceraldehyde-3-phosphate dehydrogenase 2
cholinesterase 2
glyceraldehyde-3-phosphate dehydrogenase 2
AGT 2
cathepsin D 2
nitrite reductase 2
nitrite reductase 2
DAT 2
nitrite reductase 2
glyceraldehyde-3-phosphate dehydrogenase 2
adenylate kinase 2
PRPP synthetase 2
6-phosphogluconate dehydrogenase 2
cytidine deaminase 2
TDH 2
kallikrein 2
6-phosphogluconate dehydrogenase 2
alpha-amylase 2
lactase 1
Lod 1
aldehyde dehydrogenase 1
monoamine oxidase 1
CaMKII 1
diamine oxidase 1
pantothenate kinase 1
aldehyde dehydrogenase 1
phosphorylase kinase 1
aspartase 1
PDK1 1
RNase H 1
C3 convertase 1
ADH 1
asparaginase 1
LPL 1
caspase-8 1
caspase-9 1
LasR 1
Mg2+-ATPase 1
biotinidase 1
dihydrofolate reductase 1
tryptase 1
cholesterol acyltransferase 1
chloramphenicol acetyltransferase 1
Rex 1
deaminase 1
demethylase 1
MDH 1
chymotrypsin 1
proprotein convertase 1
lecithin:cholesterol acyltransferase 1
RNase T1 1
alpha-glucosidase 1
DNase 1
proteinase K 1
isopeptidase 1
urokinase-type plasminogen activator 1
more...
Compound
iron 1659
DNA 1447
Hemoglobin 1366
Clin 810
Dec 630
HBB 303
oxygen 255
MCH 164
calcium 100
zinc 96
glucose 91
acetate 88
lysine 87
leucine 80
His 79
Hydroxyurea 68
creatinine 66
arginine 66
alanine 65
sodium 62
Asp 61
DFO 59
phosphate 59
PMA 53
Benin 53
nitric oxide 43
Gly 40
water 39
CAA 38
Cap 37
urea 37
copper 36
GTP 34
hydrogen 34
vitamin D 34
GSH 32
GSH 32
threonine 32
ATP 29
tyrosine 27
LCR 25
TSH 24
Bantu 24
TAA 23
methionine 22
potassium 22
SDS 21
cysteine 20
EDTA 20
Cardiol 20
proline 20
EDTA 20
sulfate 19
H2O2 18
phosphorus 18
CO2 18
Ile 17
DPG 16
DPG 16
ADP 15
Phe 15
TEM 15
Pac 14
HBA 14
DEAE 14
nitrogen 14
isopropanol 14
glutamic acid 13
2,3-diphosphoglycerate 13
serine 13
Heme 13
glucose-6-phosphate 13
BMD 13
Tris 13
TRH 12
glutamine 12
valine 12
silver 12
Thyroid 12
Tris 12
COS 11
aspartic acid 11
aspartic acid 11
aspartic acid 11
aspartic acid 11
Insulin 10
acrylamide 10
bromide 10
salt 10
tryptophan 10
ACTH 10
butyric acid 9
GAP 9
glycerol 9
ADP 9
BTT 9
selenium 9
ADP 9
Busulfan 9
A 3 9
N-acetylcysteine 9
MDA 9
TCA 8
6-12 8
VPM 8
Desferal 8
ATA 8
cAMP 7
FAD 7
CCC 7
NADPH 7
diacetate 7
CAT 7
Phosphatidylserine 7
TOF 7
ASA 7
acetic acid 7
AAT 7
Optimal 7
NADPH 7
uridine 7
Triton X-100 7
Neo 7
TNF 7
butyric acid 6
Hemin 6
Hemin 6
butyric acid 6
CAM 6
pyrimidine 6
Hemin 6
G11 6
Isoproterenol 6
5-Azacytidine 6
Methotrexate 6
ammonium 6
acetonitrile 6
Hemin 6
methanol 6
ethanol 6
pyrimidine 6
AAA 6
GPT 6
Hemin 6
CCC 6
iodine 6
isoleucine 5
CAT 5
MTX 5
tin 5
CAT 5
PGA 5
tryptophan 5
isoleucine 5
Vitamin E 5
tryptophan 5
hexose 5
Ascorbic acid 5
ITP 5
tryptophan 5
more...