Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0039730 (thalassemia)
 10,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors studied the clinical efficacy of the local external use of fibronectin obtained from autoplasma by heparin cryoprecipitation in 8 patients with immune complex pathology, paraproteinemic hemoblastoses and beta-thalassemia complicated by erosive and ulcerous skin lesions. Autofibronectin was shown to bring about complete healing of ulcerous defects within 10 to 45 days. The therapeutic approach suggested is money-saving and excludes a possibility of transmitting hepatitis B and immunodeficiency viruses by the patient.
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PMID:[The clinical efficacy of autofibronectin obtained by heparin cryoprecipitation in patients with trophic skin lesions]. 181 73

The plasma beta 2-microglobulin (beta 2-MG) levels in 118 children with thalassaemia were investigated. The mean level was higher than in healthy children. A significant increase of beta 2-MG was associated with hypersplenism (3.14 +/- 0.6 mg/l). The beta 2-MG levels appeared to reflect reticuloendothelial system activity but were not related to iron overload. Fibronectin levels were generally lower than in healthy adults; profound chronic fibronectin depletion was not accompanied by an increased liability to infection.
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PMID:Plasma beta-2-microglobulin and fibronectin levels in beta-thalassaemia. 642 39