Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0039730 (thalassemia)
 10,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Porotic hyperostosis was observed in 34 percent of 539 crania excavated from sites in Arizona and New Mexico. Common causes of this cranial pathology in the Old World (thalassemia, sickel cell anemia, and malargia) do not explain its occurrence in the American Southwest, as malaria and hemoglobinopathies are not known to have existed in the New World prior to European contact. Iron deficiency anemia which may also be assoicated with porotic hyperostosis occurs on a mass level only with hookworm infestation or nutritionally-related iron deficiency. Since hookworm infestation is rare in the American southwest and has not been reported in prehistoric southwestern American Indians, the hypothesis of nutritional anemia was examined. In canyon bottom sites where the diet was heavily dependent on maize, which is low in iron and also contains an inhibitor of iron absorption, significantly more crania had porotic hyperostosis than in sage plain sites, where the diet included ample animal protein rich in easily absorbable iron (p less than .001). Furthermore, canyon bottom children, who were more susceptible to iron deficiency anemia, had a higher incidence of porotic hyperostosis lesions than adults (p less than .0001).
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PMID:The paleoepidemiology of porotic hyperostosis in the American Southwest: Radiological and ecological considerations. 110 84

A study of 10,378 school children of 6-17 years old from six southern and northern provinces of china, where there was no hookworm disease or thalassemia was made. All the children selected were healthy, with normal development and well nourished. Abnormal children and national minorities were excluded. After taking vermifuge before experiment, the subjects were given FeSO4 tablet 100 mg/day for 60 days, at same time they were given dietary instructions. Hb was measured before taking FeSO4 and two weeks after stop taking the drug. Based on the results of Hb values of children with supplemented iron, deriving percentile curves, according to percentile 5 and the reference suggestions used at home and abroad, the following (criteria) for screening anemia of Chinese children are suggested: [table: see text]
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PMID:[Study of screening criteria for anemia among school children in China]. 203 13

Yirrkala is an Aboriginal community in north-east Arnhem Land in the Northern Territory. Residents aged five years and over participated in a survey to establish the prevalence and causes of anaemia. Eleven per cent were anaemic (haemoglobin level less than 110 g/L). Most of these were iron deficient, and this deficiency was attributed, at least in part, to hookworm infestation; 15% were folate deficient; none was vitamin B12 deficient. There was no haemoglobinopathy, thalassaemia trait or glucose-6-phosphate dehydrogenase (G6PD) deficiency detected.
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PMID:Anaemia in Yirrkala. 372 17

Anemia in pregnancy is a global health problem affecting nearly half of all pregnant women worldwide. High fetal demands for iron render iron deficiency the most common cause of anemia of pregnancy, with other micronutrient deficiencies contributing less frequently. In certain geographical populations, human pathogens such as hookworm, malarial parasite and human immunodeficiency virus are important factors in anemia of pregnancy. The hemoglobinopathies, sickle cell disease and thalassemia, represent diverse causes of anemia of pregnancy, requiring specialized care. Aplastic anemia is a rare, morbid cause of anemia of pregnancy and is managed with transfusions until the completion of pregnancy.
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PMID:Anemia in pregnancy. 2144 28

Anemia is the most frequent derailment of physiology in the world throughout the life of a woman. It is a serious condition in countries that are industrialized and in countries with poor resources. The main purpose of this manuscript is to give the right concern of anemia in pregnancy. The most common causes of anemia are poor nutrition, iron deficiencies, micronutrients deficiencies including folic acid, vitamin A and vitamin B12, diseases like malaria, hookworm infestation and schistosomiasis, HIV infection and genetically inherited hemoglobinopathies such as thalassemia. Depending on the severity and duration of anemia and the stage of gestation, there could be different adverse effects including low birth weight and preterm delivery. Treatment of mild anemia prevents more severe forms of anemia, strictly associated with increased risk of fetal-maternal mortality and morbidity.
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PMID:Iron deficiency anemia in pregnancy. 2647 66