Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0039483 (giant cell arteritis)
 3,204 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study we assess the presence of antibodies against infectious agents as well as for a variety of autoantibodies in an attempt to establish associations between various vasculitides and infections in order to shed light on the etiopathogenesis of these diseases and perhaps implicate a potential cure. Sera from patients with Wegener's granulomatosis (WG), polyarteritis nodosa, microscopic polyangiitis, Churg Strauss, and giant cell arteritis were compared to healthy control sera. Serum samples were assessed, using the Bio-Rad BioPlex 2200, for the presence of Toxoplama gondii, cytomegalovirus (CMV), Epstein-Barr virus (EBV), Treponema pallidum, and Saccharomyces cerevisiae. Hepatitis B virus (HBV), hepatitis C virus (HCV), and anti-Helicobacter pylori antibodies were assessed by ELISA. In addition, sera were tested for a panel of antibodies associated with thrombophilia as well as various autoantibodies. The prevalence of antibodies toward HCV and H. pylori was significantly higher among patients with WG. IgG antibodies toward T. gondii and IgM antibodies toward CMV were significantly more common among WG patients than among controls. WG patients exhibited more antibodies toward EBV viral capsid antigen IgG and EBV early antigen IgG compared to sera from healthy controls. In WG, positive associations were disclosed between CMV IgG antibodies and the presence of gastrointestinal manifestations and renal involvement, and there was a higher Birmingham vasculitis activity score in association with elevated titers of EBV viral capsid antigen IgG antibodies. Otorhinolaryngeal manifestations were more common in those with positive IgG antibodies for EBV early antigen. Our results unveil novel associations between WG and various infectious agents, including HCV, H. pylori, T. gondii, CMV, and EBV. In addition to putative roles in initiation and exacerbation of the vasculitic process, it seems that these infectious agents also modulate the clinical phenotype of the disease.
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PMID:Infectious serologies and autoantibodies in Wegener's granulomatosis and other vasculitides: novel associations disclosed using the Rad BioPlex 2200. 1975 11

Mosaic and yellowing symptoms were observed on winter barley during March of 2002 in northeastern Spain. Symptoms were similar to those caused by Barley yellow mosaic virus (BaYMV) and Barley mild mosaic virus (BaMMV), members of the genus Bymovirus (family Potyviridae). Leaves from 17 samples of barley were analyzed by enzyme-linked immunosorbent assay (ELISA) using antisera specific for BaYMV (Bio-Rad Laboratories, Hercules, CA) and BaMMV (Loewe Biochemica, Munich). Five samples tested positive with the BaYMV antiserum, and two samples were positive with the BaYMV and BaMMV antisera. Ranges of ELISA values were from 3.8 to 13 times higher than the negative controls with the BaYMV antiserum and from 18 to 21 times higher with the BaMMV antiserum. Mixed infections were further analyzed by reverse transcription-polymerase chain reaction (RT-PCR) using specific primers that amplify 433 bp of BaYMV (1) and 445 bp of BaMMV coat protein gene (primer 1: 5'GCG TCC GTT GCA ACT GA 3' and primer 2: 5'GAA TTG CTT GTG CCA ACA 3'. A PCR product of the expected size was observed with BaMMV primers but not with BaYMV primers. The sequence of BaMMV PCR product was determined and compared with that of the equivalent regions of other BaMMV isolates (Genbank Accession Nos. AJ242725, AJ224872, D83410, D83408, L49381, Y10973, and Y10974). The greatest nucleotide identity (96 to 98%) was found with isolates from Germany and Italy, followed by those from France and the United Kingdom (89%), and the lowest identity being with isolates from Asia (85 to 88%). The BaYMV presence needs to be confirmed. To our knowledge, this is the first report of a bymovirus infecting barley in Spain, and illustrates the continuing spread within Europe of viruses vectored by Polymyxa graminis Led. Reference: (1) D. Hariri et al. Eur. J. Plant Pathol. 106:365, 2000.
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PMID:Occurrence of Barley mild mosaic virus on Barley in Spain. 3081 79