Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0039483 (
giant cell arteritis
)
3,204
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A novel mutation of the
N-RAS
gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the
N-RAS
gene. Threonine (ACA) was substituted for alanine (
GCA
) at codon 11. This mutation would have been overlooked by conventional probe hybridization techniques. A search for other mutations in
N-RAS
exon-1 in T-ALL revealed a codon 13 mutation substituting aspartic acid (GAT) for glycine (GGT) in one of 18 patients. No mutations at codon 12 were detected.
...
PMID:N-RAS mutations in T-cell acute lymphocytic leukaemia: analysis by direct sequencing detects a novel mutation. 266 Sep
