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Target Concepts:
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Query: UMLS:C0039483 (
giant cell arteritis
)
3,204
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Histopathological examination of temporal artery biopsy (TAB) remains the gold standard for the diagnosis of
giant cell arteritis
(
GCA
) but is associated with essential limitations that emphasize the need for an upgraded pathological process. This study pioneered the use of full-field optical coherence tomography (FF-OCT) for rapid and automated on-site pathological diagnosis of
GCA
. Sixteen TABs (12 negative and 4 positive for
GCA
) were selected according to major histopathological criteria of
GCA
following hematoxylin-eosin-saffron-staining for subsequent acquisition with FF-
OCT
to compare structural modifications of the artery cell wall and thickness of each tunica. Gabor filtering of FF-
OCT
images was then used to compute TAB orientation maps and validate a potential automated analysis of TAB sections. FF-
OCT
allowed both qualitative and quantitative visualization of the main structures of the temporal artery wall, from the internal elastic lamina to the vasa vasorum and red blood cells, unveiling a significant correlation with conventional histology. FF-
OCT
imaging of
GCA
TABs revealed destruction of the media with distinct remodeling of the whole arterial wall into a denser reticular fibrous neo-intima, which is distinctive of
GCA
pathogenesis and accessible through automated Gabor filtering. Rapid on-site FF-
OCT
TAB acquisition makes it possible to identify some characteristic pathological lesions of
GCA
within a few minutes, paving the way for potential machine intelligence-based or even non-invasive diagnosis of
GCA
.
...
PMID:Full-field optical coherence tomography for the diagnosis of giant cell arteritis. 3286 79
