Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0039483 (
giant cell arteritis
)
3,204
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In cell-free protein synthesis studies with RNA from phage
MS2
as template, normal Escherichia coli tRNASer3 promotes two base translocation at
GCA
alanine codons with a resultant shift of ribosomes to the minus one reading frame. Similarly, normal tRNAThr3 promotes two base translocation at CCG proline codons. These conclusions were reached by amino acid sequencing of tryptic peptides or cyanogen bromide fragments that contained the reading frame shift site. It is proposed that these frameshift events occur by a two-base pair interaction between the anticodons of these exceptional tRNAs and the noncognate codons.
...
PMID:Characterization of ribosomal frameshift events by protein sequence analysis. 371 Oct 97
