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Query: UMLS:C0039483 (giant cell arteritis)
 3,204 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A report is presented of 15 patients with ocular manifestations of temporal arteritis. Ophthalmoscopy revealed anterior ischaemic neuropathy of the optic nerve in 12 patients, occlusion of central retinal artery in 2 cases and secondary atrophy of the optic nerve in 1 patient. No involvement of eye muscles of other ocular complications were seen. 10 patients showed occult temporal arteritis, whilst classical features were present in 5 patients. The diagnosis was proven histologically, and high-dosage cortisone therapy was instituted. 13 out of the 15 patients could be saved from blindness of both eyes. Temporal arteritis is an ophthalmological emergency which requires immediate diagnosis and therapy.
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PMID:[Ocular manifestations of temporal arteritis (author's transl)]. 722 6

Temporal arteritis (giant cell arteritis) is a systemic vasculitis which characteristically affects the older age group. It is of specific concern to the clinician in that a significant portion of those patients with the disease may develop, in the course of their illness, irreversible blindness in one or both eyes. The disease is usually preceded by clinically definable ocular and systemic symptoms which may allow an early diagnosis and with the appropriate treatment the abortion of certain of the adverse sequels.
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PMID:Temporal arteritis. 737 75

Temporal headache, blindness, and polymyalgia rheumatica are well-recognized manifestions of giant cell arteritis. However, the disease may present in less evident fashion as shown by 30 of 74 patients with biopsy-proven giant cell arteritis whose predominant complaint was not one ot these cardinal symptoms. For this group of 30, the main problem was fever in 12 patients, anorexia, weight loss, and elevated serum alkaline phosphatase level suggesting an occult malignancy in 7, and unexplained anemia in 3. Four patients had a neurologic syndrome; 2 had diplopia and 2 acute weakness of one arm. Claudication was the chief complaint of 4 patients, involving the leg in 1, the arm in 1, and the jaw in 2. All patients responded well to steroid therapy.
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PMID:Presentation of occult giant cell arteritis. 738 40

Twenty-five patients with biopsy-proven giant cell arteritis (GCA) were treated at the Royal Adelaide Hospital from 1973 to 1978. Three patients had a normal ESR on presentation. Four patients developed monocular blindness, one had gangrene of the tongue, and one had a brain-stem stroke. Six patients had concurrent autoimmune thyroid disease, one suffered from myasthenia gravis and one had ulcerative colitis--a significant observation in view of the suggestion that GCA has an immunological basis.
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PMID:Giant cell arteritis. A five-year review of biopsy-proven cases in a teaching hospital. 739 75

A 57-year-old female patient with ischaemic papilloedema developed vascular pseudopapillitis of the opposite eye three months later. Temporal arteritis was diagnosed by means of a biopsy of the temporal arteries. Such cases of occult temporal arteritis are characterized by the absence of typical general symptoms and pathological laboratory findings, or, alternatively, these symptoms appear only much later than the ischaemic alteration to the fundus. Hence, one should consider occult temporal arteritis when confronted with any ischaemic process of the optic nerve, and also in the case of occlusion of the central retinal artery, expecially in cases with a simultaneous rise in the blood-sedimentation rate, since high doses of steroids, when given in time, may prevent total loss of sight.
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PMID:[Occult temporal arteritis--a case report (author's transl)]. 740 51

A case of a patient with headache, visual deficiency in his left eye quickly worsening up to blindness and ischemic necrosis in the scalp regions supplied by the superficial temporal arteries, is reported. This acute gangrene began as a bandlike ischemic lesion in the temporo-parietal regions of both sides, rapidly enlarged, and acquired bizarre irregular outlines. Laboratory investigations and particularly superficial temporal artery biopsy confirmed the diagnosis of Horton's temporal arteritis, in accordance with the anamnestic and clinical data assessed at admission.
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PMID:[Multiple gangrenous lesions of the scalp in a case of cranial arteritis]. 756 55

Giant cell arteritis (GCA) is an autoimmune condition with a predilection for the arteries of the head and neck. Because GCA may lead to permanent blindness, stroke, or death, it is critically important for all health care personnel, in particular ophthalmic nurses, to know about the presentation, diagnostic methods, and treatment modalities related to this disease. Prompt intervention may save a life.
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PMID:Giant cell arteritis. 758 45

The authors presented a case of a woman, 78, with anterior ischaemic optic neuropathy--presumed Horton's disease. During 3 weeks before the patient was referred to the clinic, she had complained of strong head-, jaw- and ear-ache, bad general feeling and decreased appetite. At this time the patient was examined by a neurologist, a laryngologist and an internist, who did not find any pathology. The aim of this paper is to take into consideration the importance of early diagnosis in acute ischaemic optic neuropathy, especially that of arteritic etiology, which very often leads to blindness. This disastrous course could be avoided by early applied steroid therapy.
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PMID:[Acute ischemic optic neuropathy]. 763 6

Giant cell arteritis, a vascular inflammatory disorder of unknown etiology, is most often observed in Caucasian females over age 50. The vascular changes, involving the cranial arteries, result in oral and perioral symptoms as well as headache and scalp tenderness. Since involvement of the ophthalmic artery can result in visual disturbances and sudden blindness, dentists must be familiar with the signs and symptoms of this condition and refer patients for immediate medical assessment and care. Oral corticosteroid therapy is the treatment of choice.
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PMID:Implications of giant cell arteritis in older adults. 787 66

Temporal arteritis or giant cell arteritis occurs most commonly in elderly individuals. The lesion is usually restricted to the temporal arteries, but rarely, those elsewhere in the body may be involved. The symptoms include a pulsatile headache, usually in the temporal regions, together with anorexia, fever, jaw claudication and muscle pain, known as polymyalgia rheumatica. Histopathological study shows a granulomatous inflammatory lesion with mono-nuclear cell infiltration, associated with Langhans type giant cells, involving mainly the tunica media. Temporal arteritis is not considered to be a life-threatening disorder, however, visual disturbance, the most serious complication, may appear in those with affection of the ophthalmic artery, resulting in blindness in approximately 26% of the untreated cases. Therefore, early diagnosis by temporal artery biopsy and immediate steroid administration should be the keynote of successful therapy for preventing such a critical complication and for relief of the symptoms.
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PMID:[Temporal arteritis]. 793 98


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