Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0039483 (giant cell arteritis)
 3,204 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-two cases of temporal arteritis were reviewed. All patients were adults with a mean age of 69.6 years, and no sex predominance. The erythrocyte sedimentation rate was raised and there was a good response to steroid therapy in the 29 patients who were adequately documented and followed up. Detailed histopathological study of the temporal artery biopsies showed three main histopathological variants; 12 cases (37.5%) had predominantly intimal proliferative changes, four cases (12.5%) had granulomatous inflammation without giant cells and 16 (50%) had granulomatous inflammation with giant cells. The predominantly intimal change variant, consisting of a cellular proliferation of fibroblasts and myointimal cells with little or no changes in the media represent an active pathological process and not a healed disease as has been previously suggested. The internal elastic lamina showed abnormal features in all three morphological variants. The need to recognize this variant, the temporal relationship between these variants and the need to study multiple sections are discussed. Biopsy of clinically normal temporal arteries in patients suspected of having temporal arteritis is recommended as some of these vessels may show disease. No correlation was observed between the clinical picture and the histopathological findings.
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PMID:Temporal (granulomatous) arteritis: a histopathological study of 32 cases. 46 23

Giant cell arteritis has been thought to occur only in white patients. There have been several recent reports of this disorder to blacks, however, and this case of biopsy-proven giant cell arteritis in a black patient indicates the diagnosis should be considered in any elderly patient with typical symptoms regardless of race.
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PMID:Giant cell arteritis in a black patient. 47 60

Transitory oedema of the left orbit and maxillary sinus was revealed radiographically in an active phase of temporal arteritis. This is possibly caused by inflammatory changes of the soft tissues in these regions. Early signs of compromised retinal flow and anterior ischemic optic neuropathy were demonstrated with fluorescein angiography. This finding promoted early, immediate therapy.
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PMID:Unusual ocular manifestation in temporal arteritis. A case report. 47 83

Duplicate platelet survival studies were carried out on 8 patients with giant cell arteritis (GCA), once before the institution of any therapy, and the second time when they were in a completely asymptomatic phase after having received corticosteroid treatment. The time interval between the studies ranged between 5 and 14 months. In the first study the mean peripheral platelet count was 486 +/- 25 X 10(9)/l and in the second 326 +/- 25 X 10(9)/l. The difference between the means was highly significant (P less than 0.001). The mean life-span of the platelets was normal in the duplicate experiments (6.7 +/- 0.3 and 7.3 +/- 0.4 days, respectively). Platelet production rate was significantly (P less than 0.001) raised in the first experiment but became normal in response to corticosteroid therapy. It is concluded that the thrombocytosis seen in GCA is reactive to the inflammation present in this disease, and it seems reasonable to assume that the reduction in the peripheral platelet count which occurs in response to corticosteroid therapy accurately reflects the clinical improvement of the patient.
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PMID:Thrombokinetics in giant cell arteritis, with special reference to corticosteroid therapy. 48 82

We reviewed the charts of 47 patients with biopsy proven temporal arteritis, hospitalized in 9 major hospitals in Israel. The age of onset and clinical manifestations of this disease in Israel are similar to those reported from other parts of the world. The disease is more frequent (greater than x 3) in Ashkenazi than in Sephardic Jews and only 1 patient was Arab. More than half of the patients (20/32) had laboratory evidence of liver damage reversible with treatment. Follow-up of 19 of these patients revealed that the treatment with corticosteroids was continued in most patients for more than 2 years.
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PMID:Temporal arteritis in Israel. A review of 47 patients. 49 May 27

We report 5 cases of temporal arteritis associated with a diabetes whose good evolution under corticotherapy suggests a common pathogenesis. Several hypotheses can be formulated to explain the origin of the glycemic abnormality and to understand the way corticotherapy is effective. A moderate posology could at first have a hyperplasic effect on the insulin-secreting cells, and later on a favorable action on the vascular lesion and on an immunological disorder. Any definitive conclusion cannot be evolved yet. Only a more systematical study of the glycoregulation's abnormalities in the temporal arteritis will enable to answer the many remaining questions.
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PMID:[Corticosteroid-sensitive chemical diabetes in Horton's disease]. 49 79

A total of 136 patients with histologically proven temporal arteritis were seen in the Lothian Region of Scotland in the 14-year period, 1964-77. This study is a review of these cases with particular reference to incidence, age, sex, seasonal occurrence, along with clinical features, general and visual prognosis. It also comments on treatment, the adverse effects thereof, and the differential diagnosis. A seasonal effect significant at the 1 per cent level was established with a peak occurrence in January.
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PMID:Temporal arteritis. A 14-year epidemiological, clinical and prognostic study. 49 41

A case of hemiplegia in a 46 year old woman is described. Total occlusion of the right internal carotid artery was discovered at angiography. Because of persistent elevation of the ESR, and characteristic plasma protein abnormalities, biopsy of the temporal artery was carried out and demonstrated the typical features of giant cell arteritis.
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PMID:Internal carotid artery occlusion caused by giant cell arteritis. 50 73

Asbestos and other fibrous aerosols have been shown to cause respiratory disease. There has been a continuing search for improved monitoring methods to evaluate workers exposure to fibrous aerosols, especially asbestos. Work is continuing in several areas on the use of light scattering from fibers for their detection. A contract with GCA/Technology, which was completed in FY 77, resulted in a portable survey instrument. We have investigated the capabilities of this instrument and it looks very promising. The basic behavior and characteristics of the detection system for this instrument is the subject of a current NIOSH grant to the John B. Pierce Foundation. In-house work in FY 76 indicated that the use of light scattering for the detection of fibers directly on filter samples was promising A current contract at leeds and Northrup will result in an instrument based on this work and should provide some relief in the future for people who are involved in manual counting of asbestos.
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PMID:Recent developments in fibrous aerosol measurements. 51 63

Liver changes were demonstrated in six elderly patients with giant-cell arteritis (temporal arteritis, three with polymyalgia). Histologically there was fatty infiltration in four and pericentral congestion in five, star-cell nodules in one and non-specific hepatitis in one. Bromsulphalein test was abnormal in all, but rapidly became normal as the arteritis was successfully treated with corticoids. The pathogenesis of the liver changes is unclear. The authors' observations and published reports suggest that they are typical of giant-cell arteritis; it is of importance in the diagnosis of underlying disease.
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PMID:[Liver changes in giant-cell arteritis: temporal arteritis and rheumatic polymyalgia (author's transl)]. 52 Jan 54


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