Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038454 (
stroke
)
147,016
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mg
2+
-deficiency is linked to hypertension, Alzheimer's disease,
stroke
, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg
2+
can regulate vascular functions, yet the mechanistic insight remains ill-defined. Data show that extracellular Mg
2+
enters endothelium mainly through the TRPM7 channel and
MagT1
transporter. Mg
2+
can act as an antagonist to reduce Ca
2+
signaling in endothelium. Mg
2+
also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg
2+
-signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg
2+
-treatment through S1P1-Rac1 pathways and barrier-stabilizing mediators including cAMP, FGF1/2, and eNOS. Mg
2+
also promotes cytoskeletal reorganization and junction proteins to tighten up the barrier. Moreover, Mg
2+
-deficiency enhances endothelial barrier permeability in mice, and Mg
2+
-treatment rescues histamine-induced transient vessel hyper-permeability in vivo. In summary, Mg
2+
-deficiency can cause deleterious effects in endothelium integrity, and Mg
2+
-treatment may be effective in the prevention or treatment of vascular dysfunction.
...
PMID:Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1. 3155 37
