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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper is devoted to the examination of 137 patients with angina of effort and CHD painless form detected in the course of a cooperative study of multifactor prevention of myocardial infarction and cerebral stroke among the male population aged 40-59 in the city of Kaunas. It was shown that the attitude to health and change of harmful habits did not differ in the groups of patients with various types of arrhythmias, but, on the whole, the group of patients with angina of effort and CHD painless form was characterized by a more negative self-estimation of their health and a more positive attitude to preventive measures.
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PMID:[Interrelation of the psychological characteristics with arrhythmia in patients with stenocardia of effort and the pain-free form of ischemic heart disease]. 342 89

During examination on the basis of a double blind test corinfar administered sublingually at a dose of 10-30 mg decreases significantly in 1 hour systolic and diastolic arterial pressure, general peripheral resistance, increases the heart rate, the blood stroke and minute volumes and a medium rate of the circular contraction of the muscular fibers in CHD patients. An increase in systolic discharge is associated with lowered arteriole tension.
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PMID:[Effect of corinfar on hemodynamics in ischemic heart disease]. 352 17

The paper presents the results of the study of medical impact of AUCPAHP. The study was performed in an organized population comprising 43197 males aged 40-54 years, including an intervention group of 23378 subjects and a control group of 19819. The active, mainly secondary prevention of arterial hypertension in 12 collaborative centres during 3-5 years has caused a decrease in overall mortality in the intervention group by 17.3% compared with that in the control group, in stroke mortality by 52.4% and non-fatal MI morbidity by 23.9%. CHD mortality has turned out to be practically equal in the two groups.
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PMID:[Results of the secondary prevention of arterial hypertension. Study Group of the All-Union Collective Program for the Prevention of Arterial Hypertension (AUCPPAH)]. 370 20

The authors described the use of radionuclide ventriculography in dynamic and static variants to determine left ventricle volumetric values. The results obtained were correlated with those of roentgeno-contrast ventriculography (the correlation coefficient R was 86.8%) and literature data on echocardiography. The end-diastolic, end-systolic and stroke volumes (EDV, ESV and SV), the mean ejection rate (MER) and the total ejection fraction (TEF) were determined in controls and patients with chronic CHD. With growing severity of disease, EDV, ESV were on the increase, whereas SV and MER were on the decrease. The determination of left ventricle volumetric values permitted improved diagnosis and differential diagnosis of cardiovascular diseases.
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PMID:[Determination of left ventricular volumes using radionuclide ventriculography]. 374 52

The effects of long-term (10 years) management at a special out-patient hypertension clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and cardiovascular morbidity have been studied in 686 middle-aged male hypertensives. The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The hypertensive patients were derived from a random sample of men, aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of patients, but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the patients achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney (albuminuria, serum creatinine) involvement remained unchanged or increased slightly during follow-up. Angina pectoris (AP), intermittent claudication (IC) and congestive heart failure (CHF) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% (AP), 0.6% (IC) and 0.6% (CHF). ECG signs indicating subclinical heart disease were risk factor for AP and CHF. Smoking was an independent risk factor for any one of these cardiovascular disorders. The 10-year incidence of total mortality was 11.1%, and of CHD and stroke morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum cholesterol, AP and proteinuria. A previous stroke, smoking and proteinuria were independently associated with stroke morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Hypertension in middle-aged men. Management, morbidity and prognostic factors during long-term hypertensive care. 386 85

This study of cerebrovascular lesions at autopsy among Hawaiian Japanese men identifies similar risks factors for cerebral infarction and hemorrhage that have been identified in a previous incidence study. Demonstrated differences were essentially the same whether subjects with these tissue changes were compared to men showing no central nervous system disease at autopsy or when they were compared with men still alive. Cerebral infarcts accompanied myocardial infarction (CHD) in 58% of autopsy cases and were associated with CHD risk factors (high serum cholesterol, hypertension, severe atherosclerosis of the coronary arteries and aorta). These associations did not persist when CHD cases were removed from the analysis, indicating there were two subsets of men with cerebral infarction. Hypertension was strongly associated with hemorrhagic disease, as were cigarette use and alcohol consumption.
Stroke
PMID:Risk factors related to ischemic and hemorrhagic cerebrovascular disease at autopsy: the Honolulu Heart Study. 669 27

The hemodynamics and contractility of the myocardium were investigated in 38 men with coronary heart disease using maximal leg isometric load. It was shown that the systemic response to the isometric load in CHD patients unlike in normal subjects was mediated through increased total peripheral resistance rather than through an increase in myocardial contractility and stroke volume. The degree of these changes corresponded to the exercise tolerance as determined by bicycle ergometry. Leg isometric load is an accessible method for evaluating myocardial contractility in CHD which makes it possible to detect its disorders at the earliest stages in functional class I patients.
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PMID:[Changes in hemodynamics during isometric loading in ischemic heart disease]. 672 7

The results of examining 373 patients with a quantitative equilibrium radionuclide ventriculography were stored in a data bank and evaluated statistically. The following left ventricular parameters were evaluated: global and regional ejection fractions ( gEF , rEF1 - rEF5 ) and volume parameters (EDV, ESV, stroke volume, cardiac output, heart index). It appeared that in stages I and II of coronary heart disease evaluation of gEF , EDV and ESV under resting conditions does not sufficiently discriminate diseased patients from normals. Significant changes (p less than 0.025) of these parameters (vs. normal) were found only in CHD III and IV or in patients with a history of old myocardial infarction. The additional evaluation of the regional fraction yields, however, a significant increase (CHD I and II: +25%) of the sensitivity of the equilibrium radionuclide ventriculography in the diagnosis of coronary heart disease.
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PMID:[Quantitative equilibrium radionuclide ventriculography at rest in the evaluation of the severity of coronary disease]. 672 93

This paper reviews key aspects of the relationship of diet to coronary heart disease, as demonstrated in epidemiologic and other research over the last 25 or more years. It summarizes the extensive findings that have demonstrated an etiologically significant association among dietary lipid, serum cholesterol, and coronary heart disease; between caloric imbalance and two of the major CHD risk factors, hypertension and hypercholesterolemia; on the relationship between habitual diet high in sodium and hypertension. It also reviews the data on the relationship of habitual dietary lipid intake of individuals within a population to the serum cholesterol and CHD risk of individuals, indicating that valid positive findings in this area are consistent with evidence from cross-population epidemiologic studies, controlled experiments on diet change in man, and findings from animal research. It delineates the controlled experiments on diet change in man, and findings from animal research. It delineates the methodological problems that have stood in the way of the sound elucidation of this matter, and of the similar ones making it difficult to fully resolve the issue of the relationship of habitual dietary sodium intake of individuals within a population to their blood pressure. It reviews recent findings on the relationship of diet, particularly dietary lipid and calorie balance, to fractions of plasma total cholesterol, i.e., LDL-cholesterol, VLDL-cholesterol, and HDL-cholesterol, and summarizes the evidence indicating that recommendations for improved nutrition in the United States--emphasizing sizable reduction in saturated fat and cholesterol intake, moderate decrease in intake of total fat and of refined and processed sugars, and of calories for overweight persons--produce changes in plasma lipidlipoprotein levels that are favorable in all respects. Finally, it summarizes the findings with respect to the marked decline in mortality from coronary heart disease, stroke, all cardiovascular diseases, and all causes in the United States from 1968 to 1978, and presents evidence indicating that improvements in life style (eating, smoking, and exercise habits) and control of high blood pressure have contributed significantly to these trends.
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PMID:Diet and coronary heart disease. 704 25

The validity of death certification of stroke was studied in the general population cohort at Framingham, MA. During the last 30 years, 5106 people aged 30 to 62 and free of CHD and stroke at entry have been followed for the development of cardiovascular disease including stroke. Of the 280 decedents with certified stroke 113 (40% false negative rate) had no mention of stroke on the death certificate. THe false negative rate increased significantly with increasing age at death and increasing interval from last stroke to death. Among the 216 certificates listing stroke there were 46 false positives (21%). Analysis by type of stroke disclosed marked over-reporting of cerebral hemorrhage and under-reporting of cerebral embolus. This comparison of prospectively collected data to death certificates should raise questions about the accuracy of studies dependent on ths source of information.
Stroke
PMID:Accuracy of death certification of stroke: the Framingham Study. 714 96


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