Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this single-blind, placebo-controlled trial was to assess whether long-term treatment with nifedipine can have a beneficial preventive effect on the cardiovascular complications in the elderly hypertensives. Randomization took place in 11 clinical centers between July 1987 and June 1988, and involved 1,666 patients, 60-70 years of age. 912 participants were assigned to nifedipine (N group) and 754 to placebo (P group). Follow-up time for each participant was taken as the time from randomization to either the study events or June 1990, with an average of 30 months (27-36 months). The results showed that the cumulative rates for all cardiovascular study events in the N group were significantly lower than that in the P group at 18 months (chi 2 = 5.278, P < 0.05), and the cumulative rates for stroke in the N group was significantly decreased at 24 months (chi 2 = 4.612, P < 0.05), at 27 months, 16.00% and 36.91% (chi 2 = 5.080, P < 0.05), respectively for the N and the P groups. The incidence of stroke in the N group was decreased by 57% within 2.5 years, but cardiac events were not significantly lowered (14%, P > 0.05) in comparison with the P group. The benefits of treatment in the trial seemed to depend on age at entry and were more obvious in male than in female patients.
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Oct
PMID:[A prospective study on the effect of nifedipine of the cardiovascular complications in the elderly hypertensives]. 130 17

Berberine increased coronary artery flow of anesthetized open-chest canines and isolated guinea pig hearts with ventricular fibrillation induced by electric stimulus. The rabbits were protected by berberine from ischemic ECG changes caused by posterior pituitary hormones. Spasm of isolated swine coronary arterial rings responded to ergometrine was able to be prevented and treated effectively by berberine. On isolated swine coronary arterial strips, berberine shifted norepinephrine cumulative dose-response curve rightward parallelly without decreasing the maximal response. The pA2 value was 6.7. Contraction treatment effects post-PBMV, the cardiac function tended to decline with time, the decrease of ejection fraction, stroke volume and cardiac output were 0.03 +/- 0.007, 5.44 +/- 1.04 ml and 0.44 +/- 0.08 L/min respectively. This might be due to the unsuccessful control of activity of rheumatism after PBMV and it is necessary to pay attention to in the future.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Aug
PMID:[The role and mechanism of berberine on coronary arteries]. 198 58

The left ventricular performances (LVP), assessed by two dimensional echocardiography (2 DE) pre- and post-percutaneous balloon mitral valvuloplasty, showed a good linear correlation with those by angiography, the correlative coefficients being 0.94 (left ventricular volume), 0.93 (ejection fraction) and 0.90 (stroke volume), respectively. The results showed that 2 DE may be used in follow-up study of left ventricular performances instead of angiography. Accordingly, it was found that the short-term (6-10 months) effect in LVP of 57 cases post-PBMV assessed by 2 DE in comparison with that pre-PBMV was statistically very significant (t = 3.73-12.92, P less than 0.001); the long-term (12-42 months) effect of 88 cases post-PBMV evaluated by 2 DE compared with that pre-PBMV was statistically very significant (t = -3.73-10.46, P less than 0.001); all these showed that both the short-term and long-term cardiac functions post-PBMV had markedly improved. However, there was a significant difference in statistics (t = 2.41-3.14, P less than 0.05-0.001) between the short-term and long-term cavity area) and radionuclide angiography both during early diastole (r = 0.94) and atrial systole (r = 0.90). The above results were better than those obtained from pulsed Doppler (E area/Total, A area/Total) and radionuclide angiography: during early diastole (r = 0.78) and atrial systole (r = 0.76). Color Doppler can be used as a new method for assessing the pattern of left ventricular filling.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Aug
PMID:[Studies on left ventricular performances pre- and post-percutaneous balloon valvuloplasty in 57 cases]. 208 81

The prevalence of coronary events was 64.5/100,000 in the urban of shijia zhuang and it was higher than 23.8/100,000 in rural. Contrary to the coronary events, the prevalence of stroke in urban (159.6/100,000) was lower than that in rural (170.2/100,000). The paradox was studied with their relation to nutrition. The SBP and DBP levels, hypertension rate, serum cholesterol, BMI and dietary saturated fatty acid and cholesterol in urban were higher than that in rural. They were risk factors especially to coronary events. The urban inhabitants had high animal protein intake and higher serum amino acids and higher SO4 excreted in daily urine than that of the rural inhabitants. The result suggests that the higher animal protein intake may be preventive factor for stroke in urban inhabitants.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Oct
PMID:[The relationship between nutrition and prevalence of coronary events and stroke in urban and rural areas of Shijiazhuang]. 820 Mar 14

For long time, there has been controversy on the use of digitalis in acute myocardial infarction (AMI). Hemodynamic studies before and after the use of cedilanid, simple QRS scoring, changes on the score of AMI and cardiac arrhythmia were analysed on 24 cases of AMI. Results of the pre- and post-medication values were improved as following: (1) Cardiac index (CI) were 2.34 +/- 0.2 and 3.21 +/- 0.26L/min/m2 two hours after medication (P < 0.05). (2) Left ventricular stroke work index (LVSWI) were 31.2 +/- 3.4 and 40.1 +/- 2.2 g-m/beat/m2 two hours after medication (P < 0.01). (3) Pulmonary capillary wedge pressure (PCWP) were 19.5 +/- 2.4 and 13.2 +/- 2.1 mmHg two hours after medication (P < 0.01). (4) Myocardial oxygen consumption triple index (TI) were 182000 +/- 14000 and 142000 +/- 12000 two hours after medication (P < 0.01). (5) There was no change or with only trivial aberration on systemic vascular resistance (SVR) and perfusion pressure of the coronary arteries (CCP). (6) Simple QRS scoring on electrocardiogram resulted that the size of infarcted areas were 4.02 +/- 0.3 points before and 3.01 +/- 0.23 points after the medication (P < 0.01), there was neither ventricular premature beats (VPB) nor increase of any other serious cardiac arrhythmias in the electrocardiogram care and record in 72 hours. From the hemodynamic studies, the beneficial effect of cedilanid is greater than its adverse effect. It is concluded that digitalis can be safely and effectively used in the treatment of AMI.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Apr
PMID:[A study on the hemodynamic effect of cedilanid in the treatment of acute myocardial infarction]. 822 68

Failure of several putative neuroprotectants in large multicentred clinical trials has re-focussed attention on the predictability of pre-clinical animal models of stroke. Model characterisation and relationship to heterogeneous patient sub-groups remains of paramount importance. Information gained from magnetic resonance imaging (MRI) signatures indicates that the Zea Longa model of rat middle cerebral artery occlusion may be more representative of slowly evolving infarcts. Understanding the molecular changes over several hours following cerebral ischaemia will allow detailed characterisation of the adaptive response to brain injury. Using a fully characterised model of Zea Longa middle cerebral artery occlusion we have used the representational difference analysis (RDA) subtractive hybridisation method to identify transcripts that accumulate in the ischaemic cortex. Along with a number of established ischaemia-induced gene products (including MCP-1, TIMP-1, hsp 70) we were also able to identify nine genes which have not previously been shown to accumulate following focal ischaemia (including SOCS-3, GADD45gamma, Xin).
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PMID:Characterisation of gene expression changes following permanent MCAO in the rat using subtractive hybridisation. 1153 40

Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with hypertrophic cardiomyopathy (HCM), and represents an important complication in the clinical course of the disease, with adverse consequences on functional status and outcome. Studies on community-based HCM patient populations have shown that AF is associated with long-term clinical deterioration, cardioembolic stroke and increased cardiovascular mortality due to heart failure and stroke. Moreover, acute onset of AF may cause severe hemodynamic impairment and represent a trigger of potentially lethal ventricular arrhythmias. However, the consequences of AF on the long-term prognosis of HCM patients are not uniformly unfavorable, and may be compatible with an uneventful course, when properly managed. Management of AF in HCM is challenging, particularly when onset occurs at a young age. Both paroxysmal and permanent AF represent clear indications for oral anticoagulation. In most patients, maintenance of sinus rhythm is highly desirable but made difficult by the limited long-term efficacy and potentially hazardous side effects of available pharmacological options. In selected patients with HCM and severely symptomatic AF, radiofrequency catheter ablation may represent an effective therapeutic alternative, improving functional status, and reducing or postponing the need for antiarrhythmic drugs. In patients with persistent AF, in whom maintenance of sinus rhythm is not feasible, adequate ventricular rate control should be pursued aggressively by atrio-ventricular node blocking agents.
Zhonghua Xin Xue Guan Bing Za Zhi 2009 Apr
PMID:[Atrial fibrillation in hypertrophic cardiomyopathy: determinants, clinical course and management]. 1979 63

The 2010 Chinese guidelines for the management of hypertension is an update of the previous versions in 2005 and 1999. A guideline committee of nearly 100 members appointed by the Chinese Hypertension League (CHL) and the National Centre for Cardiovascular Disease (NCCD), in collaboration with the Chinese societies of cardiology, nephrology, neurology, gynecology and endocrinology, convened on several occasions and discussed the guidelines, drafted by a core writing group. The prevalence of hypertension has been increasing in China for decades, and reached 18.8% in the year 2002. The rates of awareness, treatment and control for hypertension patients remain low compared to high income countries, in spite of substantial improvements since 1991. In some communities, the control rate of hypertension increased up to 60%. The mortality rate of stroke, which is the major complication of hypertension in the Chinese population, gradually decreased during the period, more so in urban areas than in rural areas for the middle-aged and elderly populations; in the younger age groups, however, it increased. As hypertension is a "cardiovascular syndrome", the management strategy should be based on the overall risk of cardiovascular disease estimated with all related risk factors, target organ damage and co-morbidity of patients. The target blood pressure is set at SBP/DBP < 140/90 mm Hg (1 mm Hg = 0. 133 kPa) in uncomplicated hypertension; < 150/90 mm Hg for the elderly (> or = 65 years) or, if tolerable, < 140/90 mm Hg; and < 130/80 mm Hg for those with diabetes, coronary heart disease or renal disease. For these high risk patients, the management should be individualised. In general, lifestyle modification, such as sodium restriction, smoking cessation, moderation of body weight and alcohol consumption, and increasing dietary potassium intake and physical activity, should be implemented for prevention and control of hypertension. Five classes of antihypertensive drugs, including calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin type II receptor blockers, diuretics and beta-blockers, as well as single pill combinations of these agents, can be used for initial and maintenance of antihypertensive treatment. Several populations require special attention in the prevention and control of hypertension, such as children and adolescents, the elderly, pregnant women, and patients with various cardiovascular complications. Since health-care policies and resources vary substantially from one place to another, two levels of recommendations of management are proposed: a sophisticated and a basic, allowing doctors-in-charge to manage their patients in a more feasible way.
Zhonghua Xin Xue Guan Bing Za Zhi 2011 Jul
PMID:[2010 Chinese guidelines for the management of hypertension]. 2208 39

Persicae Ramulus decoction, as the first prescription in Treatise on febrile Diseases, has been recommended by physicians of successive generations. It is also the general prescription for harmonizing yingfen and weifen, yin and yang, qi and blood. Although it only consists of five herbal medicines, it has a wider range of application and more categorized formulas than other prescriptions. Though Persicae Ramulus decoction was originally formulated to treat taiyang apoplexy, it has functions beyond the treatment of exopathic diseases. This formula is also effective in treating internal diseases, surgical diseases, gynecologic diseases, paediatric diseases, etc. KE Yun-bo praised it as the No. 1 formula among ZHANG Zhong-jin's formulas as well as the general prescription for harmonizing Yin and Yang, yingfen and weifen, resolving fleshy exterior and inducing perspiration. Professor SHI Xin-de has been expert at treating intractable diseases by using Persicae Ramulus-associated prescriptions, such as Xiaojianzhong decoction and Baohe pill for children's chronic eczema, Persicae Ramulus and Puerariae Lobatae Radix decoction and Yupingfeng powder for chronic nephritis, and Persicae Ramulus and Longgu Muli decoction for insomnia. Instead of being restricted to Chinese or Western disease names, he prescribed appropriate formulas according to syndromes, thereby achieving a good efficacy.
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PMID:[Essence of professor SHI Xin-de's experience in application of persicae ramulus-associated prescriptions]. 2527 84

History of Famous Family in Xin'an includes abundant information and important value of the medical cultural history, including the medical family, medical ethics and the number of the famous doctors and its distribution, the medical books and its outline the medical ethics, the diseases. As for the 115 famous doctors recorded in this book, Shexian county owns the most while Jixi county owns the least, and of the average number of famous doctors among the 10, 000 local people, Yixian county owns the most while Xiuning county owns the least. History of Famous Family in Xin'an includes 26 medical books, ranging from medical literature study, gynecological treatment, external medical treatment, diagnosis and treatment of pediatric diseases, ancient medical case records, medical education, acu-moxibustion and summary of other medical experiences. The book also demonstrates the noble morality of doctors, development of doctor' family, and records of paralytic stroke, epistaxis, tuberculous consumptive diseases, furunculosis, dystocia and some infectious diseases.
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PMID:[The cultural and medical significance of Xin an mingzuzhi(History of Famous Family in Xin'an)]. 2704 48


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