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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Stroke Data Bank initiated by National Institute of Neurological and Communicative Disorders and Stroke (USA) has been adapted and published here in a short form. The original questionnaire has been extended with data of patients' diets and neuropsychology. A suitable computer data basis derived from 1292 questions in 22 groups provides information about the risk factors, etiology, symptoms, signs, diagnosis, prognosis of stroke, and the easy to use follow up of patients.
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PMID:[The Budapest "stroke data bank" (goals, methods)]. 154 26

Indices of self-reported depression and psychological adjustment after stroke were evaluated using a short form of the MMPI. Patients with poststroke periods of 2 to 6 and 7 to 24 months were selected, and indices of general intellectual functioning and lesion size/location were obtained. Despite similar levels of intellectual functioning and lesion parameters, the longer duration group showed significantly higher depression scores and significant (T greater than 70) elevations on several other clinical scales of the MMPI. In contrast, the mean overall profile of the short-duration group was roughly within normal limits. These findings have implications for the clinical assessment and treatment of stroke patients and long-term psychological adjustment after stroke.
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PMID:Short- and long-term psychological status following stroke. Short form MMPI results. 202 55

Regional CNS and peripheral hemodynamic effects of the intrathecal (i.t.) administration of a substance P receptor agonist, [pGlu5,MePhe8,MeGly9]-substance P5-11 ([DiMe]-SP), were studied in anesthetized rats with the radioactive microsphere technique. It was previously shown that [DiMe]-SP caused a sympathetically mediated increase in mean arterial pressure (MAP) by an action within the spinal cord. In this study, [DiMe]-SP (5 and 33 nmol, i.t.) increased MAP. The 5 nmol dose increased resistance in cutaneous, renal, splanchnic, and adrenal vascular beds but decreased resistance, and increased blood flow in some skeletal muscle beds. Total peripheral resistance was unchanged. The 33 nmol dose increased resistance in each peripheral vascular bed analyzed and increased total peripheral resistance. Whereas each dose increased heart rate, stroke volume and cardiac output were unchanged with the 5 nmol dose and were reduced with the 33 nmol dose. Neither dose of [DiMe]-SP significantly altered regional brain or spinal cord blood flows. These data show that the i.t. administration of the SP agonist, [DiMe]-SP, increased vascular tone to most peripheral vascular beds whereas the low dose caused a vasodilation of skeletal muscle. These effects are consistent with the notion of a dose-related activation of SP receptors in the spinal cord affecting sympathetic outflow to the adrenals and to the vasculature.
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PMID:Regional peripheral and CNS hemodynamic effects of intrathecal administration of a substance P receptor agonist. 245 Jan 16

The neurotransmitter substance P acts also as a potent vasodilator. Its participation in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt hypertension was evaluated by an acute infusion of a newly synthesized, potent, specific nonpeptide antagonist of substance P at the NK-1 receptor, the agent CP 96,345. In conscious unrestrained rats, CP 96,345 induced significant and sustained increases in mean arterial pressure of DOCA-salt rats but only small, transient, and nonsignificant rises in blood pressure of sham-treated control rats. The rise in blood pressure was not accompanied by changes in heart rate. Maximal blood pressure increase in DOCA-salt rats was 31.7 +/- 14.8 mm Hg. In a second series of experiments, the hemodynamic effects of this antagonist were evaluated under anesthesia in both DOCA-salt and sham-treated control rats by the thermodilution method. During CP 96,345 infusion, sustained increases in cardiac index and stroke volume and decreases in total peripheral resistance were observed in both DOCA-salt and control rats. In DOCA-salt rats, cardiac index rose by 79.4%, while total peripheral resistance fell by 27.9% of the baseline values. In control rats, the changes were smaller (+27.2% and -22.5%, respectively). Stroke volume changed in parallel to cardiac output in both groups. The data suggest that acute blockade of NK-1 receptors increases blood pressure in DOCA-salt rats mainly by an increase in cardiac output. We conclude that endogenous substance P tends to counteract the DOCA-salt-induced elevation of blood pressure by modulating both cardiac output and peripheral resistance.
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PMID:Cardiovascular effects of a specific nonpeptide antagonist of substance P (NK-1) receptor in DOCA-salt hypertension. 749 93

The aim of this study was to describe the relationship between hypertension and health-related quality of life (HRQL) in a Swedish general population using the 36-item short form questionnaire (SF-36). The study is based on a postal questionnaire that was sent to a random sample of 8000 inhabitants aged 20-84 years (response rate 68%) in Uppsala County, Sweden, in 1995. The results showed that those with hypertension scored lower in the linear regression analyses in most of the eight domains of the SF-36 than those without hypertension after controlling for age, sex, sociodemographic factors, and comorbidity. Diabetes and angina pectoris were related to lower scores in most of the domains of the SF-36. Previous myocardial infarction was associated with lower general health and vitality. Those with a previous stroke had lower scores in physical functioning, general health, vitality, and social functioning. The findings suggest that hypertensives represent a vulnerable population that merits special attention from health care providers and systems. This is especially important given that low HRQL can be a risk factor for subsequent cardiovascular events or complications.
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PMID:Hypertension and health-related quality of life. an epidemiological study in Sweden. 1116 33

Suitable and psychometrically tested instruments to assess health-related quality of life in stroke patients are still lacking in German speaking countries. The current paper describes the translation and psychometric testing of the German version of the Stroke Impact Scale, which was developed as a self- and proxy- report measure in the United States to assess the consequences of a stroke. The instrument contains 64 Likert-scaled items and assesses eight dimensions of health-related quality of life ("strength", "memory and thinking", "emotion", "communication", "ADL/IADL", "mobility", "hand function", and "participation"). The questionnaire was used in a cross-sectional study of 137 persons with stroke and was psychometrically tested. The results of this psychometric testing show a good acceptance on part of the interviewees. Convergent validity of the SIS dimensions was assessed with correlation of the SIS subscales and subscales of the short form SF-36 and Nottingham Health Profile and criteria-related validity was examined by comparison of mean scores across groups defined by Rankin scores. The reliability of the questionnaire was determined through internal consistency (Cronbach's). The German version of the SIS is a reliable and valid instrument to assess health-related quality of life, but more studies are needed to make statements about sensitivity of the instrument, psychometric quality of the proxy version and suitability of the questionnaire for specific stroke subgroups.
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PMID:[Testing and validation of the German version of the Stroke Impact Scale]. 1145 11

The object of this study was to provide an expanded normative base for the Dichotic Word Listening Test (DWLT), with particular emphasis on the performance of older individuals. The normative study consisted of 336 community living volunteers. These new norms were used to compare several groups of neurologically impaired patient groups. DWLT was found to be sensitive to the presence of brain injury, and also to the degree of acute injury as measured by loss of consciousness. The results of the short form version of the DWLT test showed 100% specificity and 60% sensitivity for mildly brain-injured patients to 80% sensitivity for more severely brain-injured patients. The respective sensitivities for Left CVA and Right CVA were 55% and 88%. The present findings suggest that the DWLT is a valid and easy to use clinical tool.
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PMID:Dichotic listening: expanded norms and clinical application. 1458 55

The World Health Organization's quality of life scale - short form (WHOQOL-BREF) is a well-validated, cross-cultural tool for measuring quality of life (QOL) of patients with chronic diseases. It has been translated into over 20 languages, none of which is an indigenous Nigerianlanguage. The aim of this study was to investigate the validity of a Yoruba translated version of the WHOQOL-BREF Yoruba is the indigenous language of southwestern Nigeria. The English version of the WHOQOL-BREF was translated into Yoruba and it went through two rounds of back-translation. The English and Yoruba versions of WHOQOL-BREF were completed by 41 stroke survivors, literate in both languages. Participants were recruited through purposive sampling method from physiotherapy clinics of all tertiary health institutions in southwestern Nigeria between April and August, 2004. Data was analyzed using Spearman rank order correlation and paired t- test with the alpha level set at 0.05. Participants (24 males, 14 females) were aged 55 +/- 10.7 years and have had stroke for 28.4 +/- 6.7 months. Participants' domain scores on the Yoruba translated version of WHOQOL-BREF correlated significantly with those on its English version (r = 0.695-0.859; p = 0.000). This Yoruba version is a valid translation of the English WHOQOL-BREF and may be used for assessing QOL of stroke survivors in southwestern Nigeria.
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PMID:Validation of a Yoruba translation of the World Health Organization's quality of life scale--short form among stroke survivors in Southwest Nigeria. 1772 6

Citicoline is an essential precursor in the synthesis of phosphatidylcholine, a key cell membrane phospholipid, and is known to have neuroprotective effects in acute ischemic stroke. The aim of this study was to determine the efficacy and safety of oral citicoline in Korean patients with acute ischemic stroke. A drug surveillance study was carried out in 4,191 patients with a diagnosis of acute ischemic stroke. Oral citicoline (500-4000 mg/day) was administered within less than 24 h after acute ischemic stroke in 3,736 patients (early group) and later than 24 h after acute ischemic stroke in 455 patients (late group) for at least 6 weeks. For efficacy assessment, primary outcomes were patients' scores obtained with a short form of the National Institutes of Health Stroke Scale (s-NIHSS), a short form of the Barthel Index of activities of daily living (s-BI) and a modified Rankin Scale (mRS) at enrollment, after 6 weeks and at the end of therapy for those patients with extended treatment. All adverse reactions were monitored during the study period for safety assessment. All measured outcomes, including s-NIHSS, s-BI and mRS, were improved after 6 weeks of therapy (P < 0.05). Further improvement was observed in 125 patients who continued citicoline therapy for more than 12 weeks when compared with those who ended therapy at week 6. Improvements were more significant in the higher dose group (> or = 2000 mg/day) (P < 0.001). s-BI scores showed no differences between the early and late groups at the end of therapy. Citicoline safety was excellent; 37 side effects were observed in 31 patients (0.73%). The most frequent findings were nervous system-related symptoms (8 of 37, 21.62%), followed by gastrointestinal symptoms (5 of 37, 13.5%). Oral citicoline improved neurological, functional and global outcomes in patients with acute ischemic stroke without significant safety concerns.
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PMID:Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases. 1953 60

Little is known about health-related quality of life (HRQoL) after stroke in Chinese populations. We conducted the present study to evaluate HRQoL after stroke in a group of Chinese patients. We followed 114 patients diagnosed with a first-ever stroke for 2 years. The HRQoL at discharge, 1 year poststroke, and 2 years poststroke was evaluated with the medical outcome short form 36. After a 2-year follow-up, there were 92 (88.5%) survivors. All eight domains of the HRQoL had the lowest scores at discharge, greatly improved over the first year after discharge, and showed continuous improvement. The HRQoL of patients after stroke significantly improved in two mental health domains (social function and mental health) and all four physical health domains 2 years after discharge. However, patients with stroke still had significantly lower scores in every domain than an age-matched reference group even 2 years after discharge. Age, sex, and activities of daily living were associated with HRQoL in the mental or physical domain in patients with stroke. Our results suggest that HRQoL greatly improved 2 years after discharge in patients with stroke. This study also confirmed the usefulness of the HRQoL assessment for prognosis evaluation in patients after stroke. Further studies from Chinese populations are still warranted.
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PMID:Health-related quality of life after stroke: a 2-year prospective cohort study in Wuhan, China. 2312 64


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