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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study included 43,197 men aged 40-54 years, of whom 23,378 were in the intervention group and 19,819 in the comparison group; the number of man-years of follow-up totalled for the whole group 177,703. The study proved the efficacy of active, predominantly secondary prevention of arterial hypertension (AH), carried out in men aged 40-54 years over a period of 3-5 years in 12 centres within the framework of the cooperative programme. In comparison with the control group, the following changes were registered in the intervention group: 1) overall mortality decreased by 17.3%; 2) stroke mortality decreased by 48.4%; 3) non-lethal stroke morbidity decreased by 51.4%; 4) morbidity of non-fatal myocardial infarction decreased in the course of four years by 23.8%. In contrast to this, mortality due to ischaemic heart disease was in the intervention group and in the control group practically the same.
Cor Vasa 1988
PMID:Medical efficacy of a cooperative prevention programme of arterial hypertension. 339 Oct 41

Thermodilution cardiac output determinations and multigated equilibrium blood-pool scintigraphy were performed in ten healthy chacma baboons (Papio ursinus). The correlation was moderately good between both the radionuclide and thermodilution stroke volume (r = 0.58, SEE = 3 ml; SVth = 0.78SVr + 15.6 ml) as well as the cardiac output (r = 0.72, SEE = 0.2 liter/min; COth = 0.56 Cor + 2.1 liter/min). The attenuation depth dr as determined by radionuclide techniques was found to correlate well with the radiologically determined values dx (r = 0.8, SEE = 0.4 cm; dx = 0.87dr + 0.72 cm) which validated the depth values used in the calculations.
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PMID:Comparative radionuclide and thermodilution determinations of cardiac output and stroke volume in the baboon (Papio ursinus). 361 60

In 26 patients with acute transmural myocardial infarction, the authors studied the effect of sublingual Isodinit (isosorbide dinitrate) on haemodynamic indicators: in 12 patients on heart rate, pulmonary and peripheral arterial pressure, in 14 (of whom 6 with normal and 8 with elevated diastolic pulmonary pressure) moreover on cardiac output and peripheral vascular resistance. The results showed a decrease in pulmonary arterial pressure by 35%, in peripheral arterial pressure by 10-14%, and a slighter fall in peripheral vascular resistance; the heart rate did not substantially change. In patients with normal diastolic pulmonary artery pressure, the cardiac and stroke index and the stroke work index decreased, whereas in patients with elevated pulmonary pressure these indicators did not significantly change. The effect of sublingual Isodinit occurs 5-7 min after its administration and reaches its maximum between the 15th--45th min; after 2 hrs the effect ceases. The preparation is suitable for the treatment of congestive heart failure in acute myocardial infarction.
Cor Vasa 1985
PMID:Haemodynamic effects of Isodinit (isosorbide dinitrate) in acute myocardial infarction. 399 91

The haemodynamic values before and immediately after direct myocardial revascularization were compared in 14 patients with ischaemic heart disease. Within the first hours after surgery cardiac output decreased to 50% of the preoperative value owing to a decrease in stroke volume, wedge pressure was increased, and systemic pressure was maintained at preoperative values by a rise in peripheral resistance. After the initial decrease cardiac output again increased to preoperative values (after 7 h) and above these values (19 h after surgery). Systemic blood pressure decreased owing to rapidly decreasing peripheral resistance. Knowledge of the pattern of haemodynamics in the early postoperative period facilitates the diagnosis of untoward circulatory episodes and permits to distinguish the effect of therapy from the haemodynamic changes normally occurring during this period.
Cor Vasa 1983
PMID:Haemodynamic changes immediately following myocardial revascularization. 660 33

Among 3758 men aged 40-50 years--employees of an industrial enterprise, 291 cases of suspected myocardial ischaemia (7.7%) were detected by means of resting ECG. Further 311 cases (8.3%) of latent ischaemic heart disease (IHD) were detected using a standard cardiovascular questionnaire, and 47 other men were positive both on resting ECG (ischaemic changes) and on the questionnaire. Latent IHD was equally frequent among blue and white collar workers. Ischaemic ECG findings were positively associated with a positive questionnaire, presence of hypertension, and hypertension or stroke in family history, and inversely with the alcohol consumption. No relation was found between ischaemic ECG and smoking, hypercholesterolaemia, obesity, education, and physical activity at work or during leisure time. Positive questionnaire data correlated with hypercholesterolaemia; unexpectedly this correlation was closer among non-smokers and moderate smokers than among heavy smokers.
Cor Vasa 1983
PMID:Latent ischaemic heart disease among the male employees of an industrial enterprise. 687 42

Aortic distensibility has been determined by non-invasive techniques: radioisotope measurement, quantitative radiocardiography and indirect arterial pressure measurement with calculation of the aortic rigidity index by the formula D = PP pulse (mm or mercury) / stroke volume (ml). The index value, equalling in normotensive subjects D = 0.55 was quite close to the value obtained in haemodynamic laboratories by invasive techniques (intracardiac stroke volume and arterial pressure measurements). Using the hereby determined aortic is rigidity index by non-invasive techniques, it was established that aortic distensibility is reduced since the early phases of arterial hypertension and in early age. Lowering of aortic distensibility correlates very well with diastolic pressure rise and with advancing age of patients with arterial hypertension. The aortic rigidity index, determined by non-invasive techniques, in suggested as an additional diagnostic and prognostic criterion in arterial hypertension.
Cor Vasa 1981
PMID:Determination of aortic distensibility and its variations in arterial hypertension. 724 60

Cardiac output, cardiac index (cardiac output/body surface) and stroke volume were investigated in 20 normal children by means of impedance cardiography. Significant differences were found in the mean values of cardiac output and cardiac index between both sexes, as well as in means of cardiac index between younger and older children. The obtained data generally agreed with the results of other investigators performing the examination by using the same technique and other methods.
Cor Vasa 1981
PMID:Impedance cardiography in normal children. 726 98

83 measurements of stroke volume from an impedance cardiogram and of the corresponding area under the systolic complex of the aortic flow velocity curve obtained by means of the transcutaneous ultrasound Doppler device were carried out in 15 normal children. Between the "ideal" complexes and those requiring a little reconstruction (below 10% of maximal height of the given complex) and corresponding stroke volumes, significant correlation and regression coefficients were found. It has been suggested that the aortic flow velocity curve obtained by means of the transcutaneous ultrasound nondirectional Doppler device would be helpful in approximately estimating the stroke volume in normal children.
Cor Vasa 1981
PMID:Estimation of the correlation between the transcutaneous aortic flow velocity curve and impedance cardiogram in normal children. 729 75

The decrease in the oxygen content of the inspired air calls forth enhanced demands on the cardiocirculatory performance. In experiments on healthy dogs the haemodynamic shifts connected with short-term hypoxia were investigated, with particular attention to the possible presence of irreversible changes in the myocardium. With the aid of radiocardiography the following parameters were investigated before, during and after hypoxic test: blood volume, cardiac output, stroke volume, heart frequency, ejection fraction, mean right-to-left circulation time, and segmental lung volume. In dependence on the degree of hypoxia characteristic changes in the above parameters occurred. After the end of hypoxia most parameters returned to their initial levels. The presence of irreversible changes could not be proved. Under the given conditions, it was possible to test the individual level of cardiocirculatory performance with the aid of hypoxia similarly as by using the exercise test.
Cor Vasa 1981
PMID:[Changes in circulatory parameters in dogs under general respiratory hypoxia]. 733 6

The article presents a review of experimental modelling of hypertension with the purpose helping research on its pathogenetical mechanisms, its characteristic, its therapy and eventual prophylaxy. Both conventional and genetic experimental models of inducing hypertension are discussed. The paper comprises a short description of the methods, their possibilities, the form of human hypertension to which each model corresponds, as well as the most important peculiarities of the alterations which are induced by the corresponding method. Special attention was paid to the most recent models of genetically determined spontaneous hypertension including spontaneously hypertensive rats (SHR-Okamoto-Aoki), the New Zealand strain of genetic hypertension (GH-Smirk), the stroke prone and stroke resistant substrains of SHR (SHRSP and SHRSR), arteriolipoidosis prone SHR (SHRLP), the obese SHR stain, the Milan hypertensive (MHS), Dahl's salt susceptible (s) and salt resistant (R) strains, and Smirk's genetic hypotensive strain of rats.
Cor Vasa 1980
PMID:Experimental models of hypertension. 739 41


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