Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The leukocyte count, leukocyte activation, lipoperoxidant (Lpo) of leukocytes and C3 in the peripheral blood were determined in 44 patients with acute ischemic stroke and the results were compared with those in age-matched healthy controls. No significant difference in mean leukocyte counts was observed between the patients and controls. The levels of leukocyte activation in the patients were significantly higher than those in the controls (137.94 +/- 38.86 U/L vs 92.22 +/- 20.29 U/L, P < 0.01), while the levels of Lpo of leukocytes and C3 were significantly lower than those in the controls (0.90 +/- 0.87 mumol/L and 0.96 +/- 0.72 g/L vs 1.57 +/- 1.29 mumol/L and 1.69 +/- 0.70 g/L, P < 0.01). The changes of these levels were in correlation with the extent of cerebral infarction. It is suggested that leukocytes might be involved in the pathophysiological process of acute ischemic brain damage. Its mechanisms and route of activation were discussed briefly.
Zhonghua Nei Ke Za Zhi 1994 Dec
PMID:[Activation and free radical formation of leukocytes in patients with acute ischemic stroke]. 776 34

In acute cerebral ischemia there are severe damages of endothelium recognized as the stimuli for secretion of endothelin-1, that is a endothelium-derived peptide and seems to be the most potent vasoconstrictor known. The goal of this study is to measure plasma endothelin-1 level in patients with cerebral infarction and determine the relationship between endothelin-1 and ischemic stroke. Plasma level of endothelin-1 was measured in 21 consecutive patients. The measurement was performed 3 times at different stages of stroke. There was a marked increase in plasma endothelin-1 level in the patients and the elevation lasted the entire acute and subacute stage of stroke. There was a correlation between the peptide concentration and infarct volume (r = 0.665, P < 0.01). The result suggests that endothelin-1 plays an important role in the regulation of brain circulation. Apparent and lasting increase in plasma level of endothelin-1 is associated with cerebral ischemia and infarction. The peptide seems to be involved in the pathophysiology of acute cerebral ischemia and have a deleterious effect in the evolution of cerebral infarction.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[Increased plasma endothelin-1 concentration in acute cerebral infarction and its clinical significance]. 786 29

Observation by using Swan-Ganz catheter on hemodynamic and oxygen dynamic changes before and after assisted volume controlled mechanical ventilation (MV) was carried out in 11 cases of chronic cor pulmonale complicated with pulmonary encephalopathy. Pulmonary vascular resistance and pulmonary artery pressure were significantly decreased by the relief of hypoxia pulmonary vasoconstriction after MV. Because of the relax of sympathetic tension, the heart rate, arterial blood pressure, pulmonary capillary wedge pressure and central venous pressure reduced simultaneously. Left and right ventricular stroke work decreased after MV, without significant change in cardiac output. Venous admixture (Qs/Qt) was markedly reduced by MV and oxygen supply-demand ratio raised. It is thus shown that marked improvement of hemodynamic and oxygen dynamic status can be induced by mechanical ventilation at an opportune moment.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[The hemodynamic and oxygen dynamic effects of mechanical ventilation in chronic cor pulmonale]. 786 30

A study on pulmonary hemodynamics, radionuclide right ventricular ejection fraction and blood gas analysis in 62 cases of COPD induced cor pulmonale at different stages showed the following results: 1. In early stage of cor pulmonale, stroke volume could not increase after exercise, it proved that cardiac reserve has been reduced; 2. With the progression of the disease, cardiac stroke volume reduced but cardiac output increased gradually, it could be considered as the evolutionary characteristic of cardiac function in chronic cor pulmonale; 3. The right ventricular stroke work was normal and could increase with the rise of after-load, reflecting the relatively effective functional compensation; 4. In acute exacerbation of cor pulmonale, the cardiac failure should be attributed to hyperdynamic type with hypervolemia; 5. Correlation analyses suggested that cardiac output decreased along with the increase of right ventricular afterload only in acute exacerbation of late cor pulmonale; PaO2 and PaCO2 have only slight influence on right ventricular function.
Zhonghua Nei Ke Za Zhi 1993 Feb
PMID:[The changes of right ventricular function in the course of COPD induced cor pulmonale]. 840 24

Plasma atrial natriuretic peptide (ANP) was measured with radioimmunoassay in 39 patients with acute stroke. The mean level was 144.3 +/- 8.7 pg/ml; this was significantly higher in comparison with those in normal controls (55.8 +/- 4.7 pg/ml, n = 20) and hypertension patients (87.7 +/- 8.0 pg/ml, n = 15). Serial measurement of ANP level in 6 patients showed that it was elevated on the first day of the stroke, reached to its peak on the second or third day and returned to normal after two weeks. Five patients had hyponatremia following the attack of stroke and the plasma ANP level was further elevated. It is suggested that elevated plasma ANP level might be a pathogenetic factor of the accompanying hyponatremia in stroke.
Zhonghua Nei Ke Za Zhi 1993 Feb
PMID:[Increased concentration of plasma atrial natriuretic peptide in patients with acute stroke and its significance]. 840 32

The fibrinolytic activity status of the patients with cerebral infarction can affect their clinical prognosis. In this case-controlled study, the plasma fibrinolytic system activities in 30 cases of cortical artery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) with a disease duration less than 3 days were assayed with a comprehensive panel including the plasma tPA activity, PAI activity, tPA releasing capacity from vascular endothelium and PAI/tPA ratio values. 30 subjects without cardiovascular and cerebrovascular disorders were served as control. The results showed that the plasma fibrinolytic system activities of the patients with aforementioned two subtypes of cerebral infarction were significantly lower than those of the controls, the results provide a theoretical basis for carrying out thrombolytic therapy in patients with ischemic stroke and suggest that recurrent cerebral infarction might be related to the high activity of plasma PAI.
Zhonghua Nei Ke Za Zhi 1995 Aug
PMID:[An analysis on the activity status of fibrinolytic system in Chinese patients with acute cerebral infarction]. 869 8

The hemodynamic and renal effects of strong diuretic atrial natriuretic peptide (ANP) were investigated in 12 patients with acute myocardial infarction. Strong diuretic ANP was administered as a bolus injection of 100 micrograms and followed by a continuous infusion of 2 micrograms/kg within 10 minutes into the right atrium via a catheter. We found that strong diuretic ANP induced an increase in cardiac index and stroke volume index. Right atrial pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, systemic vascular resistance and pulmonary vascular resistance were decreased after ANP infusion. The maximal responses were observed immediately after the infusion was completed. No significant change of arterial blood pressure and heart rate was observed. Furthermore, strong diuretic ANP also increased the urine volume, urinary sodium, urinary chloride and urinary potassium. These results suggest that strong diuretic ANP infusion may induce significant changes of hemodynamics and may be used to prevent the development of severe circulatory volume overload in patients with AMI.
Zhonghua Nei Ke Za Zhi 1995 Dec
PMID:[Hemodynamic and renal effects of strong diuretic atrial natriuretic peptide in patients with acute myocardial infarction]. 873 59

In order to compare the difference and similarity of the pathological changes in intracranial and extracranial arteries between cerebral hemorrhage (CH) and cerebral Infarction (CI), 120 autopsy cases were studied, including 42 cases of the CH, 58 cases of the CI and 20 cases of cancer as control. Medium sized intracranial arteries and their main branches, small sized intracerebral arteries, arterioles and extracranial carotid arteries (from 14 cases only) were examined with light microscopy. The ratio of lumen area to vessel area (LA-VA ratio) and the degree of narrowing of the vessels indicating the severity of arteriosclerosis were determined. Quantitative analysis was carried out with computer. The results were as follows: (1) The CH and CI patients had significantly lower mean LA-VA ratios of the medium intracranial arteries and their main branches, small intracerebral arteries and arterioles than the controls. (2) The CH patients had apparently lower LA-VA ratio of the small intracerebral arteries and arterioles than the CI patients. (3) The CI patients had significantly lower LA-VA ratio of the medium sized intracranial arteries and their main branches than the CH patients. Moreover, atherosclerotic narrowing of these vessels was also much more severe in the CI than in the CH patients. (4) Atherosclerotic narrowing of the extracranial carotid artery in the CI patients was slightly more severe than that in the CH patients. These data suggest that patients with cerebral stroke have frequently atherosclerotic lesions in the medium sized intracranial arteries and their main branches and sclerotic lesions in the small intracerebral arteries and arterioles. The principal lesion of the CH are in the small intracerebral arteries and arterioles, while those of the CI in the medium sized intracranial arteries and their main branches and sometimes in the extracranial carotid arteries.
Zhonghua Nei Ke Za Zhi 1996 Aug
PMID:[A comparative study of quantification of morphological changes in intracranial and extracranial arteries between cerebral hemorrhage and infarction]. 959 39

In this single blind, randomized multiple center clinical trial, the patients care period was divided into two stages. In the first stage (1985, 1-1989, 12), 984 cases were observed for 5 years whereas in the second stage (1990, 1-1994, 12), 2080 cases were observed and were subdivided into two groups, treat group and control, both were followed up for 5 years. The results showed that the prevalence of hypertension increased gradually. In the second stage, the average of blood pressure of the treatment group, using nitrendipine, was lower than that of the control group. There was significant difference between the two groups (P < 0.05). In the treatment group, the stroke and death rates were also decreased significantly as compared with the control group and the first stage group (P < 0.01).
Zhonghua Nei Ke Za Zhi 1997 May
PMID:[Prevention and treatment of stroke after hypertension for ten years in Hunan Province]. 1037 72

This study is a double-blind randomized controlled trial on the effect of intradermal acupuncture on insomnia after stroke. Hospitalized stroke patients with insomnia were enrolled in the study and were randomly assigned to either a real intradermal acupuncture group (RA group) or a sham acupuncture group (SA group). The RA group received intradermal acupuncture on Shen-Men (He-7) and Nei-Kuan (EH-6) for three days, and the SA group received sham acupuncture on the same points. The effect of acupuncture on insomnia was measured using Insomnia Severity Index (ISI) and Athens Insomnia Scale (AIS) at baseline and three days after treatment. To assess the effect of acupuncture on the autonomic nervous function, the subjects' blood pressure and heart rate variability were monitored. Fifty-two subjects (27 in the RA group and 25 in the SA group) were included in the final analysis. The insomnia-related scales ISI and AIS showed greater improvement of insomnia in the RA group than in the SA group. Moreover, there is a greater reduction of the number of non-dippers and a greater decrease of the LF/HF ratio (heart rate variability) in the RA group than in the SA group. These results indicate that sympathetic hyperactivities were stabilized in the RA group. It can thus be concluded that intradermal acupuncture on Shen-Men and Nei-Kuan is a useful therapeutic method for post stroke-onset insomnia as it reduces sympathetic hyperactivities.
 ...
PMID:Intradermal acupuncture on shen-men and nei-kuan acupoints improves insomnia in stroke patients by reducing the sympathetic nervous activity: a randomized clinical trial. 1993 12


<< Previous 1 2 3 Next >>