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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The haemodynamic effects of Dopamine (100, 250 and 500 mcg/min), Epinephrine (4 and 8 mcg/min), Orciprenaline (4 and 8 mcg/min) and two combinations of Dopamine 250 mcg/min with Epinephrine and Orciprenaline 4 mcg/min respectively at constant infusion rates were studied in 21 patients after cardiac surgery. Special attention was payed to four types of catecholamine infusions during which the highest cardiac index (CI), 161-168% of control, was seen: Dopamine 500 mcg/min (D 500), Epinephrine 8 mcg/min (E 8), Dopamine 250 mcg/min combined with Epinephrine 4 mcg/min (D 250 + E4) and Dopamine 250 mcg/min combined with Orciprenaline 4 mcg/min (D 250 + Or 4). At the same time mean arterial pressure (MAP) was highest with D 500 (137%) and lowest during both combined infusions (120 and 125%). Total peripheral resistance (TPR) was lowest during the combined infusions (80 and 81% of control) and highest during D 500 (89%). The relative increase of stroke index (SVI) and heart rate (HR) in favor of SVI, given as a quotient SVI/HR, was highest with D 250 + E4(3.7), followed by E 8 (1.9), D 500 (1.6) and D 250 + Or 4 (1.3). It was concluded that a combined infusion of Dopamine and Epinephrine, both in low doses, is preferable to a high dose of Dopamine, or Epinephrine alone, producing the same increase of cardiac output with less afterload and less chronotropic effect than high doses of either drug alone.
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PMID:Haemodynamic effects of dopamine, epinephrine and orciprenaline (Alupent) in patients early after cardiac surgery. 34 Apr 87

Cardiac and circulatory function (cardiac output, stroke volume, heart rate, mean arterial pressure = MAP, total peripheral resistance = TPR), further renal function (PAH- and inulin clearance, filtration fraction, urinary excretion, renal sodium- and potassium excretion) were measured on 15 patients undergoing cardiac surgery to whom Dopamine and Orciprenaline were administered in increasing doses of 100 mug - up to 500 mug/min (Dopamine) and 10 mug - to 20 mug/min (Orciprenaline). An infusion of Dopamine up to 250 mug/min caused a dosis-related increase of the cardiac output up to 31% (2P less than 0.001) without essential increasing of the MAP and of the heart rate. Dopamine caused a decrease of the TPR up to 24%. Doses of Dopamine over 250 mug/min cause an increase of the MAP and of the heart rate without a real increase of the cardiac output. Renal function improved under increasing doses of Dopamine, effective renal plasma flow (ERPF) up to 74%, urinary excretion up to 130%, sodium and potassium excretion up to 60% respectively. After administering Orciprenaline in a dosis of 20 mug/min cardiac output increases up to 28%, MAP and heart rate up to 12% and 17% respectively. After the administration of Orciprenaline (20 mug/min) and Dopamine (500 mug/min) frequent extra systoles were observed without any increase of the cardiac output; MAP increased by 12%, TPR decreased by 16% after 20 mug/min of Orciprenaline. ERPF decreased slightly after Orciprenaline. Urinary excretion was reduced by a half.
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PMID:[Comparing studies on the influence of dopamine and orciprenaline on cardiac and renal function of patients after cardiac surgery (author's transl)]. 108 62