Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a series of 12 cases of pheochromocytoma, 11 patients were clinically cured by operation and one died of malignant tumor. It has been reported that of patients presenting with hypertension, 0.5 to possibly 2 per cent will be found to have pheochromocytoma. This small group of patients will have a good chance of cure of hypertension by surgical removal of the tumor. Hypertension and manifestations of hypermetabolism are classically seen in pheochromocytoma, but these symptoms vary, and hypertension may be entirely absent. Hypertension which is no longer dependent on pressor amines may result after prolonged circulation of pressor substances in the bloodstream. The quantity and proportion of the pressor amines in the circulation are largely responsible for the variable clinical picture. The Regitine(R) test is an excellent screening test but is not absolutely specific for pheochromocytoma. The histamine test should not be employed in patients whose blood pressure exceeds 160/110 mm. of mercury, lest it set off cerebrovascular accident.A modification of the Garlock transdiaphragmatic incision that was used in the present series of cases affords unparalleled exposure and facility in the removal of pheochromocytoma.
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PMID:Pheochromocytoma--a report of 12 cases. 1385 59

Ten normotensive patients diagnosed as having a CVA had Regitine tests and urinary VMA and catecholamine determinations during the first day of hospitalization. The VMA and catecholamine levels were all within normal limits (except for one elevated VMA level) but did not correlate well with each other. The average response to phentolamine was an average drop in blood pressure of 30mm. Hg systolic and 19 mm. Hg diastolic. Mechanisms by which hypertensive states or cerebral damage might effect blood pressure are discussed. It is suggested that CNS damage might induce a vasolabile or hypersensitive state via connections and consequent alterations in the autonomic vasomotor system.
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PMID:Phentolamine tests and catecholamine levels in normotensive CVA patients. 1789 60