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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a qualitative approach it was shown in 204 patients with ischaemic stroke that Computertomography is significantly more often normal and atrophy more seldom in the demented patients. In addition the importance of a bilateral distribution of infarcts in the demented group was shown as well as the more common affection of the thalamus in the demented patients as compared with the non demented group. The quantitative approach was performed with measurements of the width of the 3rd ventricle, the Huckmann, the ventricle, the cella media index as well as the calculation of an index brain/CSF density. Here the importance of total loss of substance - atrophy and infarcts - was evident, explaining why measurements of the ventricle dimensions only - apart from the distribution of infarcts - were not always relevant.
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PMID:Computertomography and vascular (multiinfarct) dementia: a qualitative and quantitative investigation. 698 81

Responses to monoamines perfused over the cortical surface through modified pial windows were monitored in 106 cats. Norepinephrine (NE) and serotonin (5-HT) were diluted in mock CSF to concentrations of 50 and 500 ng/ml respectively, levels at or near the maximum concentrations to which the cortical surface might be exposed in subarachnoid hemorrhage or damage to nearby neurons. Each cat had simultaneous one-hour perfusions of monoamine solution over one hemisphere and a control solution over the other hemisphere thus serving as its own control. The perfusion solutions were observed to be restricted to the area of the pial window, and minimal histological damage was seen with the perfusion technique. The 5-HT perfusions were associated with an almost 20% narrowing of small pial arteries and arterioles but no significant effect on regional cerebral blood flow (rCBF), cortical water content or cortical function as monitored by EEG and somatosensory evoked potentials (SEP). In contrast, NE caused cortical edema and changes in the EEG and SEP's without significant vascular effect. These results suggest a non-ischemic toxicity of NE released by subarachnoid hemorrhage or cerebral damage.
Stroke
PMID:Cortical injury without ischemia produced by topical monoamines. 706 82

In 26 patients with recent rupture of an intracranial saccular aneurysm the CSF concentrations of serotonin (5-HT) were measured repeatedly by a radioimmunoassay. The 5-HT level in ventricular CSF collected between the 2nd and 15th day after SAH ranged between less than 2 and 5 nmol/l. These did not differ from the levels found in the ventricular CSF (less than 2-3 nmol/l) and lumbar CSF (less than 2-3 nmol/l) of control patients. 5-HT concentrations did not correlate with the severity of angiographical vasospasm, nor with CSF pressure or clinical grade. In two patients with severe postoperative vasospasm, however, cisternal CSF collected during operation and contaminated by fresh blood showed 5-HT concentrations exceeding 25 nmol/l. Thus, although these results do not support the conception that 5-HT plays a major role in sustaining delayed vasospasm, they suggest that 5-HT liberated from platelets may be operative in the initiation of cerebral arterial spasm.
Stroke
PMID:CSF serotonin concentrations and cerebral arterial spasm in patients with ruptured intracranial aneurysm. 706 89

The elasticity of the craniospinal system was examined in 26 patients with grave forms of cerebral stroke. A certain role of the relationships between the intracranial pressure and contents in the stroke pathogenesis is demonstrated. The initial and "optimal" CSF pressure, the elasticity gradient, and the index of the craniospinal system reserve utilization were found to be the most informative indications of the elastic properties of the craniospinal system. Criteria for individual evaluation of the degree of the intracranial hypertension compensation are determined. A possibility of compensating the intracranial volume increase by a diminution of the cerebral blood flow volume is demonstrated.
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PMID:[Elasticity of the craniospinal system in patients with severe forms of stroke]. 706 8

The effect of intraventricular histamine on blood flow in the caudate nucleus of the cat was studied by means of the hydrogen clearance technique. Bilateral ventriculo-cisternal perfusion was installed. After a control period during which both lateral ventricles were perfused with mock CSF with the same composition, the drug under study was added to one side (experimental side) while the other side was perfused further with the control mock SCF (control side). At each point in time, blood flow at the experimental side was compared to that at the control side. Histamine (10(-3) M) caused a severe vasodilatation and this effect was completely antagonised by the H2-receptor blocker cimetidine (10(-2) M). Cimetidine had no vasoactive effects of itself in the concentration used. The H2-receptor agonist Dimaprit (10(-3) M) had a vasodilator effect although less important than histamine. Indirect evidence was gained that H1-receptors are not active in the vascular bed under study.
Stroke
PMID:Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of histamine. 710 51

In patients (n = 120) with supratentorial ischemic cerebral infarction CSF lactate was determined and a CT was carried out on the 1st, 3rd and 7th day after the stroke. On the 3rd and 7th day the comparative investigation revealed a close correlation between the measure of the ischemic edema and the level of CSF-lactate. Thus the lactate-concentration can be regarded as a measure for the spread of the edema after cerebral infarction. Already on the 3rd day CT- and CSF-lactate results allow a relatively reliable prediction for the course of the stroke. An edema grade III in CT and a CSF-lactate concentration more than 4 mmol/l were prognostically critical. On the other hand good chances of survival were indicated by a CSF lactate level under 2,5 mmol/l and an edema grade I.
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PMID:[Prognosis of cerebral ischemia. Significance of the cerebrospinal fluid lactate level and computer tomographic findings]. 710 85

We reviewed the clinical features, diagnosis, and treatment in 127 cases of cysticercosis cerebri. The chief syndromes were seizures (55.1%), hydrocephalus (37.8%), and stroke (11.8%). Serum or CSF indirect hemagglutination titers, determined in 101 patients, were positive in 84.1% of those with CSF pleocytosis but in only 42.1% of those without. Computed tomography (CT), employed in 85 patients, showed typical multiple calcifications in 64.7%. The CT scans were most useful in the surgical treatment of ventriculomeningeal infestation. Ventricular shunt implantation was performed in 40 patients with hydrocephalus and produced marked improvement in 32. Cyst resection was necessary only for patients with rapidly enlarging fourth ventricle cysts.
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PMID:Cysticercosis cerebri. Review of 127 cases. 711 41

AR-L 115 has been shown to improve left ventricular (LV) pump function in patients with advanced congestive cardiomyopathy by the intravenous and oral routes. Since AR-L 115 effects on myocardial oxygen consumption (MVO2) and coronary blood flow (CSF) are unknown, the hemodynamic, myocardial metabolic, and ECG responses to AR-L 115 (2 mg/kg bolus) were monitored at 9-, 14-, and 9-minute intervals in seven patients with coronary disease, exhibiting ischemia during pacing stress only. Maximal responses occurred at the fourteenth minute after AR-L 115. There were (average) increases in cardiac index by 30%, heart rate by 19%, CSF by 39%, MVO2 by 34%, and LV dp/dt max by 27%. There were (average) decreases in peak LV systolic pressure by 13%, LV end-diastolic pressure by 42%, systemic vascular resistance by 34%, and in coronary vascular resistance by 37%. All changes were significant (p less than 0.05). Myocardial lactate extraction, stroke work index, and stroke index remained unchanged (p greater than 0.05). The modest increase in MVO2 is possibly explained by the increase in contractility being partially offset by reductions in LV preload and afterload. AR-L 115-improved LV pump function was accompanied by moderate increases in MVO2 and CSF but without evidence of myocardial ischemia.
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PMID:Hemodynamic and myocardial energetic changes induced by the new cardiotonic agent, AR-L 115, in patients with coronary artery disease. 714 47

AR-L115 has been shown to substantially improve myocardial pump function in patients (pts) with advanced congestive cardiomyopathy by i.v. and by p.o.-route. Since AR-L115 effects on myocardial oxygen consumption (MVO2) and coronary blood flow (CSF) are unknown, the hemodynamic myocardial metabolic and ECG-responses to AR-L115 (2 mg/kg BW bolus) were monitored at the 9, 14 and 19-min interval in 7 patients coronary 3-vessel disease, exhibiting ischemia during pacing stress only. Maximal responses occurred at the 14th min after AR-L115. THere were (average) increases in cardiac index by 30%, in heart rate by 19%, in CSF by 39%, in MVO2 by 34%, and in dp/dt max by 27%. There were (average) decreases in peak systolic pressure by 13%, in PCW by 30%, in LVEDP by 42%, in systemic vascular resistance by 34%, and in coronary vascular resistance by 37%. All changes were significant (p less than 0.05). Unchanged (p greater than 0.05) remained myocardial lactate extraction, stroke work index, and stroke-index. The only moderate increase in MVO2 is possibly explained in that the increase in contractility was a least partially offset by the reductions in pre- and after load. The AR-L115-induced improved pump function was accompanied by moderate increases in MVO2 and CSF, but without evidence of myocardial ischemia.
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PMID:[Hemodynamics and metabolic-energetic expenses of the influence of AR-L115 in patients with coronary artery disease (author's transl)]. 726 26

Measurements of CSF-albumin, and S/CSF-albumin in two groups of patients with small and large infarcts failed to show BBB damage to albumin in about one half of the patients. No significant difference was found between the two groups of patients in regard to the above-mentioned parameters. The localization of the infarcts (close to the CSF or deep in the brain) did not influence the S/CSF-albumin. No correlation was found between the S/CSF-albumin and the time interval between the onset of the stroke and the lumbar puncture within 96 h. Some suggestions are put forward to explain the discrepancies between the CT-scan and S/CSF-albumin in the assessment of BBB damage.
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PMID:Blood-brain barrier integrity in patients with cerebral infarction investigated by computed tomography and serum-CSF-albumin. 734 99


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