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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors describe the role of changes in osmotic homeostasis and hemorheology in the pathogenesis of ischemic brain stroke. 48 patients experiencing an acute period of ischemic brain stroke were examined. For this purpose the following methods were employed: measurements of blood, urine and CSF osmolality by Knauer osmometer; glucose and urea by the enzymatic assay; blood electrolytes by flame photometer; aggregation of platelets, red blood cells, blood viscosity, fibrinogen, hematocrit; the ethanol test, and thromboelastography. The data obtained demonstrate that the unfavorable prognostic signs may include steady and increasing hyperosmia, rise of the mmol discriminant of osmolality to over 35-40 mOsm/l, a progressive decrease of the rheological blood parameters and of colloid-osmotic pressure together with a progressive reduction of the urine/blood osmolality, which points to the rupture of the compensation for osmotic homeostasis and decompensation for the functional system regulating the blood aggregation state.
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PMID:[Osmotic homeostasis and blood rheology in patients in the acute period of ischemic cerebral infarction]. 217 76

A sharp (16.4%) increase of blood serum osmolality very close to the critical values was found in acute period of ischemic stroke, while sodiumemia exceeded the normal levels by 50 mmol/l and more. Meanwhile, the concentrations of Na ions in liquor of such patients was not significantly increased. The levels of Ca, K, Mg ions as well as the osmolality of blood serum and liquor were stable too. The alterations of these parameters were not significantly changed in epileptic patients out of fits. Both the analysis of the reasons of hyperosmia and hypersodiumemia development and the search for the methods of their prophylaxis and correction will be quite important in further investigations.
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PMID:[Osmolality and ion concentration in the cerebrospinal fluid and blood serum in epilepsy and ischemic stroke]. 901 61