Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-one patients with symptomatic ventricular tachycardia who failed control on current anti-arrhythmics were studied. Seventy-four percent had ischemic heart disease and 81% had congestive heart failure. Patients underwent serial 24 Holter recordings and radionuclide ventriculography before, during dose titration and during long-term mexiletine therapy. Twenty-eight patients (55%) were successfully controlled. Of these, 17 (33%) remained controlled greater than or equal to 1 year. Early and late side effects were common but benign and included mostly gastric pain and nausea. Twenty-eight patients underwent radionuclide ventriculography before and during mexiletine therapy: there was no significant difference in heart rate, blood pressure, left ventricular ejection fraction, stroke volume and end-diastolic volumes before and during mexiletine. Left ventricular ejection fraction was 21.4 +/- 2.2%, (SD) and 21.3 +/- 2.2% (SD) before and during mexiletine respectively. Digoxin blood levels measured in 15 patients were not significantly changed by mexiletine. In conclusion, mexiletine is effective and safe in many patients with intractable ventricular tachycardia. It has no significant hemodynamic effects even in patients with congestive heart failure nor does it affect digoxin blood levels. Its usefulness is limited by a high incidence of gastric intolerance.
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PMID:Mexiletine: long-term efficacy and hemodynamic actions in patients with ventricular arrhythmia. 241 74

Gundelia (Gundelia tournefortii L.) is a member of the Asteraceae (Compositae) family which grows in the semi-desert areas of Iran, Jordan, Palestine, Syria, Iraq, Syria, Azerbaijan, Armenia, Anatolia and other countries. Traditionally, G. tournefortii (L.) is used for treatment of liver diseases, diabetes, chest pain, heart stroke, gastric pain, vitiligo, diarrhea and bronchitis. It is also reported to have hypoglycaemic, laxative, sedative, anti-inflammatory, anti-parasite, antiseptic and emetic effects. It has enhanced gingivas and removed water from patients having spleenomegaly. Compounds found in gundelia proved to have several pharmacological effects, e.g. antibacterial, anti-inflammatory, hepatoprotective, antioxidant, antiplatelet and hypolipemic activities. The observed pharmacological properties indicated a close association of these effects with infectious diseases, digestive disorders, high blood pressure and cancer. In traditional medicine, this plant has been prescribed in many disorders; therefore, clinical trials on the compounds ofgundelia seem essential. This study gives an overview of traditional uses of gundelia, irrespective of pharmacological studies on its effects.
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PMID:Gundelia: a systematic review of medicinal and molecular perspective. 2451 31