Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors have explored the suitability of the Mongolian gerbil as a model in aging research and reviewed data on major factors in gerbil morbidity and mortality. The gerbil is a semi-desert rodent, introduced relatively recently into biomedical research. It is moderately prolific, has a maximum survival of about 208 weeks and is easily maintained. Maternal neglect, fighting and epidemic diseases (Tyzzer's disease, salmonellosis, pneumonia) are potential causes of mortality in gerbil colonies. Obese or breeding gerbils may exhibit hyperadrenocorticism, diabetes, non-lipoid arteriosclerosis and secondary lesions in several organs. There is a high prevalence of spontaneous neoplasms in aged gerbils, especially tumors of the adrenal cortex, ovary and skin. The gerbil is a useful model of experimentally-induced stroke, but has proven unsuitable for studies of cholesterol-induced atherosclerosis. The normal and pathological anatomy of periodontal disease in the gerbil is similar in many respects to that of man.
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PMID:The Mongolian gerbil in aging research. 739 11

To develop a system to be used for confirming diagnosis of Tyzzer's disease in seropositive rat colonies, 38 Mol:SPRD, BB/Wor/Mol-BB, and Stroke-Prone rats suffering from megaloileitis were examined. All affected rats had been found by a systematic examination of 5-week-old male rats from barrier-protected colonies, sero-positive to Bacillus piliformis, the agent of Tyzzer's disease. The rats were evaluated by serologic testing, histologic examination of the ileum, liver, and heart (hematoxylin and eosin and Warthin-Starry staining), and immunofluorescence staining of tissue smears of the ileum and liver. The presence of B. piliformis was verified in 24 of the rats. All animals that had the agent in the liver or heart also had it in the ileum. The sensitivity of immunofluorescence staining for identification of the agent was higher than that for Warthin-Starry staining. Thirty-seven rats had histologic changes indicative of Tyzzer's disease in the liver, and 23 had histologic changes in the myocardium. All rats had a high titer of antibodies against B. piliformis. Having verified the presence of the agent, germ-free sentinels were placed in one of the colonies. These also became infected, as did germ-free sentinels caged with the infected rats outside the barrier unit. The number of sentinels infected increased with the age of the sentinels at introduction. To prove the absence of Tyzzer's disease in a seropositive colony, it is considered necessary to examine approximately 3,000 5-week-old rats for abdominal distension and demonstrate negative staining of the ileum for B. piliformis.
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PMID:Studies on the diagnosis of Tyzzer's disease in laboratory rat colonies with antibodies against Bacillus piliformis (Clostridium piliforme). 753 Dec 55