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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myxedema coma is a decompensated hypothyroidism which occurs due to long-standing, undiagnosed, or untreated hypothyroidism. Untreated hypothyroidism is known to affect almost all organs including the heart. It is associated with a decrease in cardiac output, stroke volume due to decreased myocardial contractility, and an increase in systemic vascular resistance. It can cause cardiac arrhythmias and the most commonly seen conduction abnormalities are sinus bradycardia, heart block, ventricular tachycardia, and torsade de pointes. The authors report a case of an elderly man who presented with sudden cardiac arrest and myxedema coma and who was successfully revived.
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PMID:Sudden cardiac arrest as a rare presentation of myxedema coma: case report. 2914 76

This report describes the management of a patient with myxoedema coma masquerading as an acute stroke (with or without 'cold sepsis'). Myxoedema coma is an endocrine emergency occurring when physiological adaptations to untreated hypothyroidism are overwhelmed by an acute precipitant. Even promptly treated, it has an associated mortality of up to 50%.
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PMID:Myxoedema Coma Masquerading as Acute Stroke. 3266 24

Hypothermic patients are rare encountered in emergency department (ED). It often represents critical condition that needs prompt management and diagnosis. Myxedema coma, which may cause severe hypothermia, is truly an endocrine emergency and needs early recognition and proper treatment. We present a case of a 47-year-old female with a history of hyperthyroidism status post thyroidectomy was brought to the ED because of progressive dyspnea associated with general weakness for one month. Hypothermia with decreased mental status and general edema were also noted. Hypothyroidism was confi rmed by laboratory examination and myxedema coma was diagnosed. The patient recovered well and there was no complication noted after intensive care with supplements of thyroxine and glucocorticoid. In conclusion, myxedema coma should be considered in decrease mental status and hypothermic patients with a history of hypothyroidism or thyroidectomy. Besides, long-standing hypothyroidism or encountering precipitating acute events, such as sepsis, cerebrovascular accident, gastrointestinal bleeding, exposure to cold, trauma or certain medications may also cause this condition. High mortality rate was reported, and the treatment should be instituted in patient with presumed myxedema coma without delay.
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PMID:Myxedema Coma Patient in Emergency Department: A Case Report. 3299 92