Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe an unusual vasculopathy in two sisters of non-consanguineous parents. The first child developed an acute hemiparesis and focal seizures at the age of 6 months during a febrile illness. Magnetic resonance imaging (MRI) of the brain showed bilateral cortical-subcortical infarction not confined to a vascular territory. Subsequently, the child had a persistent stable neurological deficit. Her younger sister had a similar encephalitis-like episode at the age of 4 months, with left-sided cortical-subcortical ischaemic lesions. Two months later she had left-sided focal seizures. MRI showed a right-sided cortical enhancement, magnetic resonance angiography (MRA) was normal. The neurological deficit was stable and she was seizure free. These episodes were initially interpreted as metabolic strokes, but work-up was normal and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) was excluded. In their teens both sisters were diagnosed with pulmonary and systemic hypertension and, due to the arterial hypertension, myocardial hypertrophy. Renal artery stenosis, pathological pulmonary arteries, and stenosis and rarefication of coronary arteries were found; the aorta and retinal vessels were normal. Repeat cranial MRI and MRA showed multiple collaterals, while the carotid and basilar arteries were extremely narrowed (moyamoya appearance). We suggest the diagnosis is a hereditary systemic vasculopathy of unknown origin.
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PMID:Siblings with infantile cerebral stroke and delayed multivessel involvement--a new hereditary vasculopathy? 1742 10

Fibromuscular dysplasia typically occurs in young women and most commonly presents with hypertension, transient ischemic attack, stroke, or an asymptomatic cervical bruit. The disease is nonatherosclerotic and noninflammatory and most often affects the renal and carotid arteries, although almost any artery can be involved. On angiography, affected blood vessels characteristically resemble a string of beads in the most common type of fibromuscular dysplasia, medial fibroplasia. Patients with renal artery stenosis and hypertension or renal impairment should be treated with percutaneous transluminal angioplasty without a stent. Patients with fibromuscular dysplasia of the internal carotid artery should also be treated with angioplasty if they develop focal neurologic symptoms such as a transient ischemic attack or stroke.
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PMID:Recognizing and managing fibromuscular dysplasia. 1743 76

We previously showed that renal artery stenosis (RAS) was commonly found in patients with cardiovascular disease (CVD) such as myocardial infarction, stroke, or abdominal aneurysm. The aim of the present study was to evaluate the incidence and risk factors for RAS in patients with severe carotid artery stenosis (CAS) considered to need carotid endarterectomy. From February to August 2006, 41 consecutive patients with severe CAS were admitted to the Department of Neurosurgery of the National Cardiovascular Center. Each patient was examined for renal function and urinary albumin excretion, and renal artery duplex scanning was also performed. The patients were classified into two groups according to the findings of renal Doppler sonography, 11 patients with RAS and 30 patients without RAS. We evaluated the differences in clinical findings and renal function between the groups and clarified the risk factors for RAS. In RAS patients, smoking and incidence of other CVDs were evident, and renal function was impaired significantly compared with the patients without RAS. Multivariate logistic regression showed that the presence of other CVDs, renal function, and smoking were significant clinical predictors for RAS. In patients with severe CAS, RAS was frequently detected with the same frequency as ischemic heart disease. The RAS risk factors were the presence of other CVDs, renal dysfunction, and smoking. Since RAS is an underlying cause of hypertension and renal failure, it is important to consider the presence of RAS in patients with severe CAS.
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PMID:The incidence and risk factors of renal artery stenosis in patients with severe carotid artery stenosis. 1803 77

This study explored the prevalence and predictors of renal artery stenosis in a cohort of 525 hypertensive patients referred for elective coronary procedures. Patients underwent coronary and renal arteriography. The study defined renal artery stenosis as > or =60% luminal obstruction (physiologic or hemodynamic significance was not tested). Patients were classified into groups of those with normal renal arteries, those with insignificant renal artery stenosis, and individuals with significant renal artery stenosis. The mean age was 52.6+/-8.5 years, and 403 (76.8%) were males. Significant renal artery stenosis was found in 3.6%. It correlated significantly with hypertension duration (P=.005), history of cerebrovascular stroke (P=.01), history of angioplasty to >1 coronary vessel (P=.003), and 3-vessel coronary disease (P=.0003). Multivariate regression analysis identified 2-vessel and 3-vessel coronary artery disease as independent predictors of renal artery stenosis, with odds ratios of 4.9 and 12.1, respectively. It was concluded that invasive screening for renal artery stenosis was probably warranted only in hypertensive patients with multivessel coronary disease referred for elective coronary procedures.
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PMID:Prevalence and predictors of renal artery stenosis in hypertensive patients undergoing elective coronary procedures. 1912 73

Renal artery stenosis (RAS) is an important cause of arterial hypertension and chronic kidney disease. The aims of our study were to assess the prevalence of RAS and to examine the frequency of variants of renal vasculature, that is, multiple and/or accessory renal arteries in hypertensive patients referred to renal angiography. We evaluated retrospectively 1554 arteriographies of hypertensive patients. Angiograms were evaluated to find RAS, significant RAS (>60% stenosis of the lumen), radiological signs of atherosclerosis, aneurysms of the renal arteries or aorta and variants of kidney vascularization. The frequency of RAS including occlusions was 15.1% (21.3% of them were significant and suitable for revascularization). Variants of renal arterial vascularization were found in 26.5% of patients (multiple renal arteries-11.2% and accessory renal arteries-15.3%). Significant RAS was found more frequently in patients older than 60 years-OR 4.76 (2.08-10.86). Coronary artery disease, history of myocardial infarction or stroke significantly increased the chance of RAS detection. The frequency of renal accessory arteries was lower in patients older than 60 years and in patients with the radiological signs of atherosclerosis. Results of this study indicate that haemodynamically important RAS is found more frequently in hypertensive patients older than 60 years. Symptomatic atherosclerotic disease found in the peripheral and/or coronary arteries and diabetes mellitus increases the chance of RAS detection. Decreased occurrence of renal accessory arteries was found in hypertensive patients with radiological signs of atherosclerosis.
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PMID:Frequency of renal artery stenosis and variants of renal vascularization in hypertensive patients: analysis of 1550 angiographies in one centre. 1912 56

Moyamoya disease is a cerebrovascular stenotic or occlusive disease predominantly seen in Asian countries. Sometimes there are coexisting renal artery lesions in Moyamoya disease patients. A 32-year-old multipara had a cesarean section at 33 gestational weeks due to preeclampsia. One month later, she developed subarachnoid hemorrhage and angiography demonstrated Moyamoya vessels with renal artery stenosis. After conservative therapy, the patient was discharged without any deficits. Our conclusion is that patients with Moyamoya disease carry a risk of cerebrovascular accident during pregnancy and postpartum. In this case, we did not diagnose Moyamoya disease with renal artery stenosis until the patient developed subarachnoid hemorrhage. It is very important to make a careful differential diagnosis of hypertension during pregnancy and the postpartum period.
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PMID:Postpartum subarachnoid hemorrhage due to Moyamoya disease associated with renal artery stenosis. 1975 43

Renal artery stenosis (RAS) is a common manifestation of generalized atherosclerosis, frequently involving other vascular districts, particularly the coronary tree. Duplex ultrasonography is the diagnostic procedure of choice for screening outpatients for RAS. We report a case of metabolic syndrome in a 63-year-old obese man with atherosclerosis and low-grade RAS that was an important sign of cardiovascular risk. In fact, cardioscintigraphy and coronary arteriography showed severe coronary artery disease. RAS is an independent predictor of adverse cardiovascular events such as myocardial infarction, stroke, and cardiovascular death. In this case, duplex ultrasonography demonstrated the importance of screening for RAS as the expression of coronary artery disease.
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PMID:[Color-Doppler ultrasound in renal artery stenosis and cardiovascular risk: case report]. 1991 53

Although recent advance of coronary intervention therapy for coronary artery disease (CAD) is remarkable, long-term clinical outcomes were similar with the past decade. Recent study demonstrated that poly-vascular disease was associated with a significant higher-risk of major adverse cardiovascular events in patients with CAD. The treatment of peripheral artery disease (PAD) reaches to improvement in exercise performance. Revascularization for atherosclerotic renal artery stenosis (ARAS) is associated with reduction in blood pressure and preservation of renal function. Revascularization for carotid artery stenosis (CAS) is associated with the prevention of stroke. Because systemic vascular diseases are related to cardiovascular events, the targeted screening by non-invasive testing for PAD, ARAS, and CAS would increase the frequency of diagnosis, the chance of revascularization therapies, and reach to the reduction in cardiovascular events.
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PMID:[Role of global vascular intervention on long-term prognosis in patients with coronary artery disease]. 2138 65

We updated the evidence-based recommendations for the diagnosis, assessment, prevention, and treatment of hypertension in adults for 2011. The major guideline changes this year are: (1) a recommendation was made for using comparative risk analogies when communicating a patient's cardiovascular risk; (2) diagnostic testing issues for renal artery stenosis were discussed; (3) recommendations were added for the management of hypertension during the acute phase of stroke; (4) people with hypertension and diabetes are now considered high risk for cardiovascular events if they have elevated urinary albumin excretion, overt kidney disease, cardiovascular disease, or the presence of other cardiovascular risk factors; (5) the combination of an angiotensin-converting enzyme (ACE) inhibitor and a dihydropyridine calcium channel blocker (CCB) is preferred over the combination of an ACE inhibitor and a thiazide diuretic in persons with diabetes and hypertension; and (6) a recommendation was made to coordinate with pharmacists to improve antihypertensive medication adherence. We also discussed the recent analyses that examined the association between angiotensin II receptor blockers (ARBs) and cancer.
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PMID:The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. 2180 75

The predominant cause of renal artery stenosis (RAS) is atherosclerosis. Clinical manifestations of atherosclerotic RAS are both direct (hypertension and kidney dysfunction) and indirect (increased cardiovascular events and mortality). However, in many cases, atherosclerotic RAS seems to be an incidental finding with no discernable effects. Antihypertensive medications such as renin-angiotensin-aldosterone system inhibitors, along with statins and aspirin, have significantly improved the medical treatment of atherosclerotic RAS. However, revascularization is still advocated in a variety of clinical settings such as the preservation of renal function, recurrent episodes of "flash" pulmonary edema, and in patients with refractory hypertension. Current management guidelines indicate "resistant hypertension" as an indication for renal artery revascularization. A large number of observational studies support revascularization for both control of high blood pressure and/or preservation of renal function. Unfortunately, the favorable effects of revascularization on these end points seen in the observational studies were not reproduced in randomized controlled trials compared to medical therapy alone. The ability for revascularization to improve control of congestive heart failure or to prevent hard cardiovascular end points (eg, myocardial infarction or stroke) has not been tested in the randomized clinical trials published to date. Hence, the efficacy of intervention remains controversial, which poses a dilemma, especially given the large number of elderly patients with resistant systolic hypertension.
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PMID:Revascularization in renal artery stenosis. 2231 44


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