Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038454 (stroke)
 147,016 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To examine the association between neuroticism and physical disorders among adults in the United States, data were drawn from the National Comorbidity Survey (n = 5,877). Multiple logistic regression analyses were used to examine the relationship between neuroticism and physical disorders among adults in the community, adjusting for differences in demographic characteristics and comorbid mental disorders.Results indicated that neuroticism was associated with significantly elevated rates of a wide range of physical disorders, with the exception of stroke. After adjusting for differences in demographic characteristics and comorbid mental disorders, neuroticism was associated with increased odds of arthritis (OR = 1.5), diabetes (OR = 3.33), kidney/liver disease (OR = 2.56), stomach/gallbladder problems (OR = 2.27), and ulcer (OR = 3.23). Based on those findings, neuroticism appears to be a general predictor of a range of physical health problems among adults in the United States. Much of this association appears to be partially mediated by comorbid mental disorders, yet the association between neuroticism and arthritis, diabetes, kidney/liver disease, stomach problems, and ulcer persist even after adjusting for differences in demographic characteristics and comorbid mental disorders. Future studies that can examine the nature and mechanism of these linkages across the lifespan are needed next.
 ...
PMID:Neuroticism and physical disorders among adults in the community: results from the National Comorbidity Survey. 1672 79

Group B streptococcal (GBS) infections are increasing in incidence as a cause of serious disease in the adult population. Risk factors for this infection include age, diabetes mellitus, liver disease, history of stroke, breast cancer and HIV infection, which are all becoming more common. We report a patient with severe GBS meningitis who made a good recovery following appropriate treatment, despite a delay in specific diagnosis of the organism. We believe this to be the first case of GBS meningitis in a non-pregnant adult in Australia or New Zealand to be reported in the literature.
 ...
PMID:Group B streptococcal meningitis in a middle-aged woman. 1753 89

Consumers throughout the world are increasingly questioning the quality and safety of their diets and how the foods they eat are influencing their health. Much of this interest stems from mounting evidence that bioactive food components cannot only influence one's ability to achieve one's genetic potential, but can also have a significant influence on the quality of life as measured by both physical and cognitive performance, and modify the risk and/or severity of a variety of disease conditions. During the past century, a wealth of evidence has pointed to dietary habits as a determinant of premature death, including that associated with heart disease, stroke, diabetes, liver disease, atherosclerosis and cancer, although considerable variability in response is evident. Several factors may account for these discrepancies including individual variability due to genetic and epigenetic regulation of cellular proteins and associated small-molecular-weight compounds. This interrelationship between the food components and the 'omics' (genomics, epigenomics, transcriptomics, proteomics and metabolomics) will be briefly reviewed as a factor contributing to the variability among studies. Expanded knowledge about these omics interrelationships will not only define the molecular target for food components but will also assist in identifying those individuals who are likely to respond maximally.
 ...
PMID:Nutrition in the 'omics' era. 1768 97

Over 27 cases of liver transplant, kidney transplant and combined liver-kidney transplant have been reported for the treatment of methylmalonic aciduria. We describe a case of a 5-year-old boy who underwent combined liver-kidney transplant (CLKT) for phenotypic mut0 disease. His history was notable for more than 30 hospitalizations for severe acidosis, metabolic strokes, liver disease, pancreatic disease, chronic renal insufficiency with interstitial nephritis, and decreased quality of life. Post-CLKT, there was a marked reduction in serum (80%) and urine MMA levels (90%) as well as a cessation of metabolic decompensations. Neurologic deterioration continued post-CKLT manifested as a cerebellar stroke. The clinical details and therapeutic implications of solid organ transplant for methylmalonic aciduria are discussed.
 ...
PMID:Combined liver-kidney transplant for the management of methylmalonic aciduria: a case report and review of the literature. 1796 41

To determine the influence of personal medical history on mortality from cancer and other chronic diseases, participants in the JACC study were questionned and followed up. Consistent across the sexes, risk of deaths of all causes was increased with hypertension, diabetes mellitus, apoplexy, liver diseases, surgical operations, and blood transfusions. All cancers were similarly related to a history of diabetes and liver diseases, surgery and transfusions. In addition, risk of liver cancer was elevated with diabetes, liver disease, cholecystectomy, renal disease, surgical operations and blood transfusions. Apoplexy was related to a past history of blood transfusion and diabetes, the latter also predisposing to ischemic heart disease. Links with infectious disease were also elucidated. Clearly, a past medical history can exert a strong influence on chronic disease development.
 ...
PMID:Personal past history and mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). 1826 Jul 2

Drug-related hepatotoxicity is now the leading cause of acute liver failure in the United States, especially among patients who have no prior liver disease. Nicardipine is the only IV calcium channel blocker available for the short-term treatment of hypertension with a considerably good safety profile. We report a case of nicardipine-induced hepatitis. A patient with history of hypertension was admitted because of right middle cerebral artery infarction. Computed tomography of the brain showed evolving stroke. The patient went for cerebral angiography and stent placement, and during the procedure he had cerebral hemorrhage. He was transferred to neurosurgery. After surgery, he was started on hypertonic saline, mannitol for cerebral edema, and nicardipine drip for blood pressure control. On the fourth day after operation, he started to have fever with progressive elevation of liver enzymes [Aspartate amino transferase (AST) 450, Alanine amino transferase (ALT) 356, and alkaline phosphatase 299]. Serum bilirubin was 0.6. He did not receive blood transfusion. No medical history of hepatitis or liver disease was reported. Other medications included metoprolol and heparin. White blood cell count was 13,000. Chest x-ray did not show evidence of consolidation. Urine analysis was unremarkable. Cultures were negative. Acute hepatitis panel was negative. Cerebrospinal fluid examination was normal. Liver enzymes were trending up gradually with normal protein and bilirubin. Computed tomography of the abdomen was unremarkable. The patient's medications were reviewed. It was noticed that the patient started to have fever and elevated liver enzymes after administration of nicardipine drip. It was postulated that nicardipine may be the culprit of acute hepatitis. Nicardipine drip was stopped, and the patient was started on labetalol. Fever started to resolve, and liver enzymes started trending down toward normal. The patient remained afebrile after that.
 ...
PMID:Nicardipine-induced acute hepatitis in an intensive care unit patient. 1909 42

Mesothel is the cell lining of serosal surface of the pleura, peritoneum, pericardium, and testis. Malignant mesothelioma is a highly aggressive tumor from mesothel that has a tendency to grow rapidly and invade locally. Although the incidence of malignant mesenterial mesothelioma is not so high, the case fatality rate is very high. The aim of this case report is to report the rare and difficult case with several complications. A Balinese man, 64 years old, came with chief complaint of weakness, abdominal enlargement, and nausea, with history of previous liver disease. On physical examination were found a decrease of conciousness, subfebrile, abdominal distension, ascites, negative traube space, and paralysis of the left side of the body. Laboratory examination results showed leukocytosis, hypochromic-micrositic anemia, trombocytosis, hypoalbuminemia, increase of alkaline phosphatase, and mild hyponatremia. Abdominal USG showed intraperitoneal mass which some of them attach to abdominal wall, possibly from mesenterium and ascites, esophagogastroduodenoscopy (EGD) revealed reflux esofagitis and anthral erossive gastritis, skull CT scan showed small infarction at left parietal medulla and right basal ganglia, cytology showed spreaded and grouped mesothel with reactive lymphocyte and amorph back ground. FNAB result showed malignant mesothelioma, and normal colonoscopy. Based on the above data, the diagnoses were malignant mesenterial mesothelioma, reflux esofagitis and anthral erossive gastritis, and non hemorrhagic stroke. Malignant mesenterial mesothelioma should be considered in patient with the combination of unexplained ascites and abdominal pain. Although the result of treatment is very disappointing, the patient had to be treated optimally to increase quality of life.
 ...
PMID:Malignant mesenterial mesothelioma in stroke patients. 1915 50

Hepatitis B surface antigen positivity (HBsAg(+)) was believed to be an exclusion for kidney donation. However, in the presence of an organ shortage, allocation of kidneys from HBsAg(+) donors to recipients with anti-HBsAb(+) might be allowed. We examined the 10-year outcomes of kidney transplants (KT) from HBsAg(+) donors to natural or vaccine-induced anti-HBsAb(+) recipients (Group 1). Hepatitis B hyperimmune globulin (HBIG) and lamivudine were not used at any time. We compared the 10-year outcomes of patients who had HBsAg(+) prior to KT and received kidneys from HBsAg(-) donors (Group 2). The endpoint was patient survival determined by Kaplan-Meier and Cox proportional hazard methods. A total of 41 patients were transplanted from 1991-1997. There were 14 Group 1 patients and 27 Group 2 patients. Anti-HBsAb titer ranged from 10 to >1000 mIU/mL. Actuarial 10-year patient survivals were 92.8% and 62.5% for Group 1 and Group 2. Only 1 patient in Group 1 died; this case was due to an acute myocardial infarction. Eleven deaths occurred among Group 2; they were due to chronic active hepatitis (n = 5), hepatoma (n = 3), acute fibrosing cholestatic hepatitis (n = 1), and stroke (n = 2). More than 2 times elevated ALT occurred among 45% of Group 2 but none in Group 1. No patients in Group 1 had positive HBsAg and HBV DNA at last follow-up. Four patients in Group 2 displayed seroconversion to positive HBeAg after KT. Secondary analysis examining the impact of KT on patient life expectancy (from the start of dialysis until last follow-up) used Cox regression, revealing that KT was significantly associated with an increased risk for death within 12 months after transplantation (RR = 30, P = .005) but a decreased risk for death thereafter (RR = .03, P = .005) for Group 2. However, KT did not have significant impact on the risk for death within the first year for Group 1 (P = .61). Our results showed that the 10-year survival of KT from HBsAg(+) donors to recipients with anti-HBsAb(+) was good. This was not associated with evidence of active liver disease. The presence of HBsAg(+) in donors thus should not be considered an exclusion for kidney donation for anti-HBsAb(+) recipients.
 ...
PMID:Ten-year follow-up of kidney transplantation from hepatitis B surface antigen-positive donors. 1924 16

The aim of this retrospective study is to examine the feasibility and safety of laparoscopic colorectal resection for colorectal malignancies to determine "high-risk" patients. In our classification, 3 minor criteria including patients over 70 years of age, body mass index over 30 m/kg, and cigarette smoking and 5 major criteria including cardiac, pulmonary, renal, liver disease, and diabetes mellitus were selected to determine a high-risk group. Patients carrying 1 minor and 1 major criteria were classified as the high-risk group. Concerning patients and operations, hemodynamic values (mean arterial systolic and diastolic pressures and heart rates), oxygen saturations, end-expiratory carbon dioxide levels, respiratory mechanics (dynamic compliance, peak inspiratory pressure, airway resistance) were analyzed. Cardiovascular system (myocardial infarction, arrhythmia, hypertension), pulmonary system (respiratory insufficiency), digestive system (anastomotic leak, fistula, and paralytic ileus), fever, thrombophlebitis, urinary infections, wound infections, and central nervous system (delirium and cerebrovascular accident) were also investigated. A total number of 85 high-risk patients were included in the study. Gastrointestinal leaks in 2.3%, fistula in 1.1%, ileus in 3.5%, postoperative bleeding in 2.3%, postoperative fever in 5.8%, wound infection in 5.8%, and cerebrovascular accidents in 1.1% of patients were detected. The lowest values of hemodynamic and respiratory mechanics were observed at the induction of pneumoperitoneum and in this period the compliance and mean arterial pressure were determined to be 36+/-14 mm Hg and 84+/-14 mm Hg, respectively. No mortalities occurred. In experienced hands, laparoscopic colorectal resection can be performed safely for "high-risk" surgical patients.
 ...
PMID:Analysis of laparoscopic colorectal surgery in high-risk patients. 1985 Dec 70

Since comorbid conditions are highly prevalent among patients with end-stage renal disease, indexes measuring them have been widely used to describe the comorbidity burden and to predict outcomes as well as adjust for their roles as confounders. The current comorbidity indexes, however, were developed for general populations or on small patient cohorts. In this study we developed a new index for mortality analyses of dialysis patients based on the 2000 US incident dialysis population, and validated this using the 1999 and 2001 incident and 2000 prevalent dialysis patient populations. Numerical weights were assigned to the comorbid conditions of atherosclerotic heart disease, congestive heart failure, cerebrovascular accident/transient ischemic attack, peripheral vascular disease, dysrhythmia, other cardiac diseases, chronic obstructive pulmonary disease, gastrointestinal bleeding, liver disease, cancer, and diabetes. A patient's comorbidity score was the sum of the weights corresponding to the individual conditions present and could be used as a continuous variable in analyses. Our index performance was almost identical to the individual comorbid conditions regarding model fit, predictive ability, and effect on inference, and it outperformed the widely used Charlson Comorbidity Index.
 ...
PMID:An improved comorbidity index for outcome analyses among dialysis patients. 2004 Sep 20


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>