Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rearing cats with surgically induced strabismus resulted in an abnormally high percentage (80%) of monocularly driven neurons in visual cortex. Microiontophoretic application of the GABA antagonist bicuculline restored binocular responses to over 50% of these monocular cells. Elevation of spontaneous rate by glutamate failed to produce binocularity. These results indicate that intracortical inhibition plays a role in the abnormal ocular dominance distribution of strabismic cats.
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PMID:Microiontophoretic bicuculline restores binocular responses to visual cortical neurons in strabismic cats. 648 7

Angelman syndrome (AS) is a rare, neurodevelopmental disorder caused by a variety of genetic abnormalities involving the chromosome 15q11-13 region. Clinical manifestations include severe psychomotor retardation, epilepsy, lack of speech, cerebellar ataxia, frequent bouts of laughing, morphological defect of the facial bones and sleep disturbance. The main anesthetic considerations in AS patients are significant dominance of vagal tone, profound disorders of GABA system with defects in its receptor function, epilepsy and peripheral muscular atrophy. We report the experience of anesthetic management for strabismus surgery in a patient with AS.
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PMID:Anesthetic experience for strabismus surgery in a patient with Angelman syndrome: A case report. 3062 74