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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fibrin sealants were used in place of the classical suture materials in strabismus surgery. Classical recession operations were performed on the right eyes of ten albino rabbits, while the recessed anterior rectus muscles of the left eyes were fixed to the sclera with the tissue sealant. Better histopathological results were obtained with the fibrin sealant than with the classical sutures, but the functional results were worse.
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PMID:An experimental study on the use of fibrin sealants in strabismus surgery. 184 79

An experimental animal study was conducted to determine whether fibrin glue could be used in strabismus surgery (recession, resection, and muscular neurotization). Fibrin glue was used in place of some or all of the commonly used 7-0 Vicryl sutures. In order to evaluate the adhesion of the fibrin glue the rabbits' eyes were enucleated 10-67 days after surgery, fixed in 8% formalin solution and then histologically examined. In the recession and resection specimens a solid joint between muscles and sclera was found, without any significant scar formation or atrophy of the muscles. The muscular neurotization specimens also exhibited a firm connection between the two muscles, with no abnormal loss of muscle fibers by cicatrization or atrophy. In none of the cases did the conjunctiva show any tendency to conglutination. In view of the simplicity of the fibrin gluing technique and the uniform bonding effect, application in human patients is recommended.
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PMID:[Fibrin gluing of the extraocular eye muscles. Experimental use in the rabbit]. 246 1

Strabismus is the lack of binocular vision due to an inability to control one of the eye muscles. Corrective surgery is the most common recourse and consists of adjusting and reattaching the extraocular muscle to the sclera. In approximately 10% of cases involving re-insertment of the extraocular muscle via suture techniques, the needle is inserted too deeply into the eye resulting in perforation of the retina. Fibrin glues and cyanoacrylates have been substituted with unsatisfactory mechanical results. The goal of this study was to maximize the tensile strength of rabbit extraocular muscles repaired using a laser-solder technique developed by McNally et al., Biodegradable polymer membranes of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) (PLGA) and salt particles using a solvent-casting and particulate-leaching technique. The porous membranes were doped with protein solder composed of 25% and 50% (w/v) serum albumin and 0.5 mg/ml indocyanine green (ICG) dye mixed in deionized water. In vitro tissue specimens were repaired using the solder-doped polymer membranes in conjunction with an 805 nm diode laser. The tensile strength was tested on an MTS machine and results were analyzed with the Student's T-test.
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PMID:Optimization of laser-solder repair technique for possible application in strabismus surgeries. 1208 31

Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures.
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PMID:Surgical adhesives in ophthalmology: history and current trends. 2958 52