Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This randomized, double-blind study evaluated the antiemetic efficacy and the side-effects of promethazine pretreatment (0.5 mg.kg-1 IV + 0.5 mg.kg-1 IM) versus droperidol + placebo pretreatment (droperidol, 0.075 mg.kg-1 IV + physiological saline, 0.02 ml.kg-1 IM). One hundred unpremedicated ASA physical status I children ranging from two to ten years, and undergoing outpatient strabismus surgery were studied. All children received inhalational anaesthesia with halothane, nitrous oxide and oxygen. Neither opioids nor muscle relaxants were used. The incidence of vomiting and/or retching and the incidence of side-effects were determined in the post-anaesthesia recovery room (PARR), in the short-stay surgical unit (SSSU), and after discharge from the hospital (including the journey and the stay at home during the first postoperative day). Promethazine and droperidol were equally effective in reducing the incidence of vomiting before discharge to two and eight per cent respectively. On the contrary, the incidence of vomiting after discharge and overall were significantly less with promethazine (ten and ten per cent) than with droperidol pretreatment (54 and 56 per cent) (P less than 0.0001). Promethazine permitted the time to discharge from the hospital to be reduced to an average of three hours, without increasing the incidence of vomiting postdischarge. Promethazine pretreatment is much less expensive than droperidol pretreatment. The incidence of restlessness was significantly less with droperidol (eight per cent) than with promethazine (36 per cent) (P less than 0.001). Promethazine pretreatment demands the use of an analgesic like acetaminophen in order to reduce the incidence of postoperative pain and restlessness.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Antiemetic prophylaxis with promethazine or droperidol in paediatric outpatient strabismus surgery. 198 40

In a clinical study the subjective acceptance as well as the quality of different visual functions was examined during the wearing of three multifocal lenses (Ciba Spectrum Bifocal, Allergan Echelon, and Essilor Variations). Ten subjects wore each of the 3 contact lens types for a period of 12 to 21 days after the binocular finding (bicentral or disparate vision within the Panum's area); further functions such as contrast or scotopic vision were qualified and/or quantified in a basic examination. All subjects (N = 5) with the binocular finding orthophoria/motorcompensated heterophoria preferred the Ciba Spectrum Bifocal. Furthermore, all visual functions of the 10 test persons were clearly reduced with all 3 multifocal contact lenses. A correlation between the "preferred contact lens and the detailed subjective acceptance" and/or the "subjective acceptance and the functional measurements" could not be proven as statistically significant.
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PMID:Acceptance of different multifocal contact lenses depending on the binocular findings. 850 60

A 17-year-old female was treated with botulinum toxin (botulinum toxin type A, Allergan) for a left convergent squint. She returned 1 week after her second injection and informed us that she found out she was pregnant 3 days after the second injection. After a long worrying 9 months, her pregnancy fortunately proceeded to term with no adverse effect on both mother and baby. A literature review reassuringly suggests that it is a relatively safe treatment with no adverse effects on the expectant mother or the fetus. Up to 300 units of botulinum toxin have been used at various stages of pregnancy without adverse effects.
Strabismus 2010 Jun
PMID:Botulinum toxin and pregnancy-a cautionary tale. 2052 81