Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A recognized complication of strabismus surgery is the development of hypertrophic conjunctival scars over the operated-on muscle. Our standard treatment of these scars has been excision followed by corticosteroid eye drops, which results in a scar recurrence rate of 33%. Antimetabolic chemotherapeutic agents, such as mitomycin, can reduce posttraumatic scarring and vascularization of the ocular surface. We studied the use of mitomycin eye drops as an adjunct to standard treatment of hypertrophic conjunctival scars after strabismus surgery. Four patients were treated with adjunct mitomycin eye drops (0.2 to 0.4 mg/ml). Postoperative follow up ranged from 16 to 56 weeks. None of these cases showed significant scar recurrence. Mitomycin in the higher dosage caused mild superficial punctate keratitis after 8 days of use. Despite a lamellar sclerectomy in a patient treated with 0.2 mg/ml of mitomycin, there was no further clinically apparent loss of scleral tissue. The results of this pilot study suggest that topical mitomycin is a safe and effective adjunct to excision and corticosteroid eyedrops in the treatment of hypertrophic conjunctival scars after strabismus surgery.
J Pediatr Ophthalmol Strabismus
PMID:Mitomycin in the treatment of hypertrophic conjunctival scars after strabismus surgery. 801 95

Mitomycin C (MMC) is a cytostatic agent topically used in conjunctival neoplasms, secondary to glaucoma filtering, pterygium, and strabismus surgery to increase the success rate. The topical formulation of MMC for ocular use is always extemporaneously prepared. Our study evaluated the stability of extemporaneously prepared formulations of MMC at different concentrations (150, 300, & 600 microg/mL) kept at different temperatures (25 degrees , 4 degrees , and -70 degrees C) and at different pH range (6, 7, and 8). Aliquots from the above formulations were subjected for quantification of MMC on days 0, 7, 14, 21, and 28 using high-performance liquid chromatography. MMC stored at 25 degrees C for 6 months was also subjected to flow cytometry and compared to freshly prepared MMC. The results indicated that the degradation of MMC is very high in acidic pH at room temperature. Increasing the pH to 7 or 8 and keeping MMC at low temperatures significantly decreased the degradation of MMC. Interestingly, the flow cytometry data revealed that the 6-month-old MMC showed an antiproliferative effect compared to that of freshly prepared MMC. To conclude, the extemporaneously prepared MMC at pH between 7 and 8 and stored in the refrigerator can increase the duration of its stability. However, the antiproliferative study using flow cytometry revealed that degraded MMC retained its activity even after degradation.
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PMID:Evaluation of the stability of extemporaneously prepared ophthalmic formulation of mitomycin C. 1596 39