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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The tissue reaction, absorption, and handling properties of Dexon synthetic absorbable sutures, which are made from polymerized hydroxyacetic acid, were compared with those of silk and collagen in 51 eye operations, consisting mainly of cataract extractions and squint corrections. There was no significant difference between the sutures as regards degree of tissue reaction. The Dexon sutures were very strong and the knots held well. The sizes used in this series were found to be a little too thick and stiff for use in micro-surgery; smaller sizes would be easier to use and still remain strong enough. The Dexon was reliably absorbed in 5 weeks on average. No serious adverse reactions were seen with any of the sutures. Dexon was as well tolerated as the control sutures but had the advantage over silk of being absorbed and over collagen of containing no foreign protein.
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PMID:Comparative trial of Dexon (polyglycolic acid), collagen, and silk sutures in ophthalmic surgery. 76 26

The new absorbable synthetic sutures, polyglycolic and (Dexon) and Polyglactin 910 (Vicryl), are excellent sutures for strabismus surgery, but they have a bothersome tendency to attract adjacent tissue (tissue-drag). This difficulty is found especially with the 5-0 size suture, less so with the 6-0 size suture, and minimally with the 7-0 size suture. The presence and number of short, stubbly, protuberant strands (hooklets) seen on the surface of these sutures under high magnification correlates with the lack of ease with which the sutures pass through tissue. Other factors involved in tissue-drag include the crevices between braids in these sutures and the fiber-tissue friction due to the innate nature of the suture materials. Sutures which pass with ease through tissue, such as catgut and nonabsorbable sutures, are seen to have smooth surfaces under high magnification. Coating the 5-0 and 6-0 Dexon and Vicryl sutures to smooth their surfaces and reduce tissue-drag was ineffective with isotonic saline solution, minimally to moderately effective with glycerine and with methylcellulose and polyvinyl alcohol solutions, but highly effective with peanut and sesame oils. Though tissue-passage of Dexon and Vicryl sutures was much improved by coating with oil and entirely satisfactory, it still was not quite as good as with catgut. Clinically, the oil did not compromise the knot security or ease of handling of the sutures. No unusual postoperative reaction was seen with the use of the oiled sutures. Although oiling the synthetic absorbable sutures at time of surgery is effective, we recommend that suture manufacturers reduce the tissue-drag of synthetic absorbable sutures either by smoothing the surface in the manufacturing process or by developing an absorbable coating applied to the sutures during manufacture.
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PMID:"Tissue-drag" with polyglycolic acid (Dexon) and polyglactin 910 (Vicryl) sutures in strabismus surgery. 101 25

From our experimental studies it appears Dexon satisfies more of the criteria for an ideal suture for strabismus surgery than plain catgut for the following reasons. Its handling, tying, and knot-holding (if tighthened firmly) qualities are excellent. Tissue reaction is minimal. It seems to be non-antigenic. Of paramount importance. Dexon's tensile strength is high initially and it retains its strength through the critical period of muscle-scleral wound healing, then dissolves in a rapid uniform manner.
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PMID:Experimental suture studies in strabismus surgery. II. Comparison of tensile strength of plain catgut with polyglycolic acid (Dexon) sutures after extraocular muscle surgery. 108 29

Polyglycolic acid, synthetic, absorbable braided suture was compared to gut with respect to handling, strength, and tissue reaction in 70 strabismus procedures. This new suture material produced less tissue reaction than gut and had handling characteristics that were similar to silk. It can be used in smaller sizes than gut because of its greater strength and firm knot. Polyglycolic acid suture appears to be a useful addition to ophthalmic suture materials.
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PMID:Polyglycolic acid suture in strabismus surgery. 109 97

6-0 Dexon (polyglycolic acid-PGA) suture was used in 30 eyes of 25 patients in surgical procedures which included cataract extraction, strabismus surgery, and ocular plastic surgery. The suture was found to hold the wound firmly, was not absorbed prematurely, was absorbed completely at a predicted time, was relatively easy to use although the knots were large, did not cause any infection or undue tissue reaction, and did not result in any wound dehiscence or vitreous loss.
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PMID:Evaluation of Dexon suture in ophthalmic surgery. 114 1

Two cases of chorioretinitis were caused by polymer material from the suture (Dexon) used in squint surgery. The lesions were macula edema, granulomatous uveitis and capillary occlusions on the ocular fundus located in the operated area. To confirm the cause of this injury, an immunological investigation was performed. Macrophage block and an incomplete adjuvant were necessary to lead delayed hypersensitivity against the synthetic polymer polyglycolic acid (PGA). The mice showed a strong reaction as hyperemia and swelling on their experimental footpads after the injection of PGA. Histologically the footpad accumulated a large quantity of lymphocytes in the swollen tissue but the control footpad had no reaction.
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PMID:Chorioretinitis caused by synthetic absorbable sutures. 133 56

Knot integrity of a new coated polyglycolic acid suture (Dexon Plus) was compared to that using uncoated polyglycolic acid (Dexon-S) and coated polyglactin-910 (Vicryl) for extraocular muscle recessions in rabbits. Knot integrity was found to be virtually identical using 6-0 sutures of any of these materials. Top throws of 5-0 coated Dexon or 5-0 coated Vicryl had a tendency to loosen in a few cases, though this was eliminated in later operations by more careful tightening of knots and avoidance of cutting suture ends to a length less than 2 mm. Subjectively observed differences in "tissue drag" were insignificant in this model.
J Pediatr Ophthalmol Strabismus
PMID:Knot integrity of coated synthetic absorbable sutures used for extraocular muscle surgery in a rabbit model. 627 14