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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The optokinetic reflex and neuronal response properties in the central visual pathway were studied in three macaque monkeys (Macaca nemestrina) with early childhood strabismus of various origin. Binocularity in the primary visual cortex (VI) measured electrophysiologically was reduced both in a monkey with resolved strabismus and in a monkey with accommodative strabismus when compared to normal controls. By contrast, binocularity in the nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system (NOT-DTN) was only reduced in the monkey with resolved strabismus ('resolved'), but appeared normal in animals with accommodative strabismus ('accom. 1 'and 'accom. 2'). Sub-threshold binocular interactions were normal in all animals. The velocity tuning curves of retinal slip neurons in the NOT-DTN of all strabismic monkeys were not different from normal controls. Horizontal optokinetic nystagmus was asymmetric in monkey 'accom. 2', and for the non-fixating eye in monkey 'resolved'. In monkey 'accom. 1' OKN was normal. Open loop eye velocity was lower in the monkey with resolved strabismus than in monkeys with accommodative strabismus. These data suggest that different causes of strabismus may affect neuronal response properties and behavior to different degrees. The effects on the optokinetic reflex of resolved, but early onset strabismus were more severe than those of accommodative strabismus. This corresponds to the wide variability of defects in the optokinetic system of strabismic humans.
Strabismus 1996
PMID:Neuronal basis of optokinetic reflex pathology in naturally strabismic monkeys. 2131 6