Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 7-year-old girl was referred for retinal dystrophy. On examination, visual acuity was 20/20 in the right eye and 20/30 in the left eye. Fundus examination revealed bilateral orange-colored subfoveal choroidal tumors. Ultrasonography showed calcification, confirming the diagnosis of choroidal osteoma. Because vision was preserved without subretinal fluid or choroidal neovascularization, observation with calcium supplementation was recommended. Three years later, there was minimal tumor growth and visual acuity was maintained. Choroidal osteomas are rare, benign tumors that may decrease vision through decalcification, particularly when subfoveal. In these cases, cautious observation and possibly calcium supplementation may help protect vision.
J Pediatr Ophthalmol Strabismus 2011 Dec 06
PMID:Progressive growth of bilateral choroidal osteomas in a child. 2214 73

One hundred twenty-eight cases of retinoblastoma were reviewed. The mean age at diagnosis, presenting signs, clinical, and pathological features were investigated. Patients with bilateral tumors presented earlier and had a higher mortality rate than those with unilateral tumors. Histopathological features such as calcification, seeding into the vitreous, and the degree of differentiation had no significant effect on prognosis. There was no predominance of exophytic, endophytic, or mixed tumor growth patterns. Extension of the tumor to extraretinal structures increased the mortality rate significantly.
J Pediatr Ophthalmol Strabismus
PMID:Prognosis in retinoblastoma: influence of histopathologic characteristics. 2487 65

Cavernous sinus meningiomas are rare benign tumors arising from the dural wall of the cavernous sinus. These complex lesions are difficult to access surgically but can lead to cranial nerve palsies if left untreated. The case described in this video involved a 14-yr-old girl who presented initially with right ocular pain at 9 yr old. Strabismus of the right eye developed when she was 10 yr old; it was treated surgically without improvement. She developed ptosis and worsening strabismus at age 13 yr, at which time magnetic resonance imaging revealed a lesion in the anterior cavernous sinus and superior orbital fissure. Given the progressively worsening oculomotor palsy and potential for future tumor growth because of her young age, the patient's family wished to pursue surgical rather than radiation treatment. The patient underwent a right lateral orbitotomy for exploration and resection of the lesion. She tolerated the procedure well. Postoperatively, she experienced improvement in her ocular pain and persistent oculomotor nerve palsy without any new neurologic deficits. Her cosmetic results from this incision were satisfactory. Postoperative computed tomography demonstrated thinning of the right lateral orbital wall and removal of the tumor. The pathological analysis of the tissue was consistent with a grade 1 meningioma. This video demonstrates the opportunity to resect a lesion from the cavernous sinus that prevents progressive cranial neuropathies. Some cavernous meningiomas are well circumscribed and can be resected totally. The patient's parents provided consent for publication.
 ...
PMID:Resection of Cavernous Sinus Meningioma via Lateral Orbitotomy Approach: 2-Dimensional Operative Video. 3150 52