Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aqueous humor of five patients with histologically proven retinoblastoma were analyzed for the main catabolic products of norephinephrine and epinephrine. In each case, there were no detectable levels of normethanephrine, metanephrine, vanilmandelic acid (VMA), and 3-methoxy, 4-hydroxy phenoglycol. The techniques are sensitive to 1 microgram/ml but will not detect the presence of homovanillic acid (HVA).
J Pediatr Ophthalmol Strabismus
PMID:Catecholamine metabolites in the aqueous of retinoblastoma. 73 36

Glaucoma drainage implants provide a useful option in the management of complicated glaucomas for which the risk of failure of conventional filtering surgery is high. The basic design of these devices is similar; a silicone tube shunts aqueous humor from the anterior chamber to a fibrous capsule surrounding a synthetic plate or band positioned at the equatorial region of the globe. The capsule serves as a reservoir for aqueous drainage. Drainage implants have been used in the treatment of various refractory glaucomas, including those associated with aphakia and pseudophakia, prior unsuccessful filtering surgery, anterior segment neovascularization, trauma, youth, uveitis, epithelial downgrowth, iridocorneal endothelial syndrome, vitreoretinal disorders, and penetrating keratoplasty. Modifications in implant design and surgical technique have been developed to limit the occurrence of postoperative complications such as hypotony and its related sequelae, and strabismus.
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PMID:Glaucoma drainage implants. 1017 32

The damage of the eye is one of the clinical syndromes of the Toxocara infection, caused by the migration activity of the Toxocara canis and Toxocara cati larvae. Ocular larva migrans (OLM) lesions mostly occur unilaterally and frequently are diagnosed as retinoblastoma. The typical symptoms of OLM are presented in our publication. The first signs of the ocular infection most often include diminished vision, leukocoria, red eye and strabismus. Inflammatory intraocular reaction, caused as a response to the antigens, released from dead or dying larvae is often diagnosed. The living larvae are observed very rarely. The reason and a way of the ocular invasion are still not sufficiently cleared. The supposition that the ocular syndrome is caused by migration of single larvae, when the immunological response is light, was not reliably verified. Sometimes if the infection size was heavy, the eye can be invaded with systemic complications as well. The most common laboratory findings include an elevation of the immunoglobulins in the serum of the patient and the presence of Toxocara specific antibodies response in the vitreous and/or aqueous humor. An analysis of the humor in cases of presumptive OLM was made only in 8 patients because not all oculists are ready to take this material, mainly in children. Highly sensitive assay--ELISA reaction with specific excretory-secretory antigen (TES) was used. For discrimination between chronic and recent infection the method of measuring IgG avidity was applied.
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PMID:[The ocular form of larval toxocariasis in the Czech Republic]. 1204 49

The authors report a case of anterior uveitis with hypopyon that was refractory to topical corticosteroid therapy. A detailed history revealed that the patient had chronic myeloid leukemia. Cytology in the aqueous humor was consistent with relapse of chronic myeloid leukemia.
J Pediatr Ophthalmol Strabismus 2009 Nov 02
PMID:Isolated Anterior Chamber Relapse in a Child with Chronic Myeloid Leukemia: Masquerade Syndrome. 1987 46

Ocular toxocariasis is an uncommon worldwide parasitic infection that affects mostly children and is found in both rural and metropolitan areas. In many parts of the world, parasitic infections of the eye are a major cause of blindness. The diagnosis of toxocariasis is essentially clinical, based on the lesion morphology and supportive laboratory data such as serum enzyme-linked immunosorbent assay (ELISA) titers and ELISA Toxocara titers on aqueous humor; other diagnostic methods are imaging studies including optical coherence tomography, fluorescein angiography, computed tomography, and ocular ultrasound. Treatment is directed at complications arising from intraocular inflammation and vitreous membrane traction. Early vitrectomy may be of value both diagnostically and therapeutically.
J Pediatr Ophthalmol Strabismus
PMID:Ocular toxocariasis. 2293 14

The authors report a rare unilateral iris and ciliary body relapse in acute lymphoblastic leukemia. Ophthalmologic examination showed reduced visual acuity, pseudohypopyon, and iris irregularity. Ultrasound biomicroscopy and aqueous humor cytology confirmed leukemic infiltration. Lesions were treated with intravitreal methotrexate, which has not been described previously for acute lymphoblastic leukemia. [J Pediatr Ophthalmol Strabismus. 2018;55:e16-e19.].
J Pediatr Ophthalmol Strabismus 2018 Aug 29
PMID:Intravitreal Methotrexate for Iris and Ciliary Body Relapse in Acute Lymphoblastic Leukemia. 3018 Feb 38