Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The outer layers of the normal retina depend on indirect nutrition originating in the choriocapillaris and supplied to the retina by way of the pigment epithelium. An eye with exophytic retinoblastoma is used to demonstrate increased vascularity and tissue substance in the adjacent choroid believed to be indirectly induced by a regional increase in nutritional requirements in the retinal zone of a developing eye.
J Pediatr Ophthalmol Strabismus
PMID:Regional uveal response to increased nutritional needs in the retinal zone of the developing eye demonstrated in an eye with retinoblastoma. 272 72

A young child was examined for unilateral hyphema of 1 month duration with a questionable history of blunt trauma. Ultrasonography was negative for tumefaction. Two months later the media cleared, revealing a diffusely abnormal retina. Computed tomography demonstrated a diffusely thickened posterior pole containing calcium. Histopathology of the enucleated globe was consistent with a diffuse infiltrating retinoblastoma. This is the first report of computed tomographic findings in diffuse infiltrating retinoblastoma.
J Pediatr Ophthalmol Strabismus
PMID:Diffuse infiltrating retinoblastoma. 272 79

From 1979 through 1987, 82 children with retinoblastoma were treated with primary external beam therapy, to one or both eyes. A total of 120 eyes were irradiated, with doses from 3850-5000 cGy. We used a lens-sparing electron beam technique from 1979 to 1984 and a modified lateral beam technique from 1984 to 1987. Comparison of outcome for eyes with Group I-III (Reese-Ellsworth) disease revealed a significant advantage for freedom from relapse favoring the lateral technique (p = 0.0009). A similar trend was noted for final eye outcome (need for enucleation). No differences were noted for eyes with Group IV-V disease. Patient survival was 90% at 4 years, with a mean follow-up time of 36 months.
J Pediatr Ophthalmol Strabismus
PMID:Results of external beam radiation for children with retinoblastoma: a comparison of two techniques. 279 13

A vascular abnormality of the optic nerve was found incidentally in two infants whose eyes were enucleated because of the clinical suspicion of retinoblastoma. The lesion consisted of numerous thin-walled vascular channels within pial septa of the retrolaminar optic nerve. Although it is unclear if this angiomatous malformation could disturb vision, the lesion may be more common than can be inferred from the small number of reported cases.
J Pediatr Ophthalmol Strabismus
PMID:Angiomatous malformation of the retrolaminar optic nerve. 327 82

An 8-month-old boy was found to have a sporadic unilateral stage IIa retinoblastoma, extending inferiorly and temporally from the right fovea. Within 5 weeks of diagnosis the tumor was treated with 4500 rads fractionated over 20 treatments. Examination under anesthesia (EUA) 1 month later revealed unequivocal clinical and echographic evidence of tumor regression. EUA 3 months after completion of radiation therapy revealed continued tumor regression with no evidence of new tumor formation. The third EUA, performed 6 months after radiation treatment, showed that multiple discreet gray-white retinal infiltrates had developed, predominantly in the area immediately below the regressed tumor. Because of concern that these lesions represented viable retinoblastoma, the eye was enucleated. Pathologic examination of these lesions revealed them to be collections of foamy cells containing melanin granules suggestive of pigment epithelial origin.
J Pediatr Ophthalmol Strabismus
PMID:Post-radiation retinal infiltrates simulating recurrent retinoblastoma: a clinical and pathologic case report. 332 Mar 27

The prevalence and mode of inheritance of major genetic eye diseases have been investigated in China since the establishment of the Section of Ophthalmic Genetics of the Chinese Society of Genetics. Mass screening of genetic eye diseases has been undertaken in many districts in China, covering more than 700,000 people, and more than 5000 pedigrees of genetic eye diseases have been collected and analysed all over China. Based on these data, the prevalence and mode of inheritance of dyschromatopsia, degenerative myopia, retinitis pigmentosa, congenital ptosis, congenital microphthalmos, congenital cataract, congenital glaucoma, Leber's optic atrophy, corneal dystrophy, congenital nystagmus, coloboma of the eye, congenital aniridia, retinoblastoma, macular dystrophy, simple myopia, primary glaucoma, and strabismus have been investigated, and the results are presented.
 ...
PMID:Prevalence and mode of inheritance of major genetic eye diseases in China. 350 Mar 13

Retinoblastoma is usually diagnosed during the first three years of life, with an average age of diagnosis of 18 months. It is almost never found at birth except when there is a positive family history which prompts an early fundus examination. We report a case of unilateral nonfamilial retinoblastoma which was so advanced at birth that it had already produced a perforated globe. Despite enucleation, radiation, and chemotherapy, massive orbital recurrence developed which necessitated a modified orbital exenteration. In spite of this aggressive therapy the child died of metastatic retinoblastoma at age eight months.
J Pediatr Ophthalmol Strabismus
PMID:Congenital retinoblastoma: a case report. 359 30

A boy was discovered to have retinoblastoma in his right eye at age 29 months. The eye was enucleated and showed invasion of the choroid and optic nerve on examination. Bone marrow aspiration was negative in January 1981. Orbital recurrence was noted 1 month later and bone marrow aspiration was positive 2 months later. MAD-DOC chemotherapy and radiation therapy to the right orbit and brain were initiated immediately. The tumor has remained in remission since completion of the chemotherapy 18 months later. A preleukemic syndrome occurred in July 1984, and a successful bone marrow transplantation was performed in November 1984. He resumed normal growth and has remained well. Metastatic retinoblastoma should no longer be thought of as invariably fatal.
J Pediatr Ophthalmol Strabismus
PMID:Prolonged survival of a child with metastatic retinoblastoma. 368 12

Retinoblastoma was diagnosed in 74 patients between July 1967 and February 1987. Thirty cases (40%) were bilateral; 39 were female and 35 were male. Treatment in bilateral cases consisted of enucleation of the more involved eye and a combined approach of supervoltage irradiation, cryocoagulation, and photocoagulation to the remaining eye. In unilateral cases the involved eye was enucleated and the uninvolved eye observed. Four patients had bilateral enucleation at their initial presentation and four others had the second eye enucleated after unsuccessful tumor treatment. One patient died from metastatic retinoblastoma, one patient died after intrathecal chemotherapy without the evidence of tumor, and one patient died with trilateral retinoblastoma. Seventy-one of 74 patients (96%) currently survive with a follow-up of 1 month to 19 years. Two-year survival is 65 of 68 (95.5%).
J Pediatr Ophthalmol Strabismus
PMID:Retinoblastoma. 369 85

We examined a 4-year-old boy who had a painful blind eye, rubeosis iridis, and leukokoria. Ultrasonography and computed tomography (CT) detected intraocular calcification and other features suggestive of retinoblastoma. The CT scan showed extraocular extension along the optic nerve. Intracranial extension of the tumor could not be definitely excluded by CT scan with intrathecal metrizamide infusion. Magnetic resonance imaging (MRI) and CT performed after radiation and chemotherapy were useful in excluding intracranial spread of malignant cells, thereby aiding the selection of a surgical approach to ensure complete removal of the involved portion of the optic nerve.
J Pediatr Ophthalmol Strabismus
PMID:The use of magnetic resonance imaging in the evaluation of retinoblastoma. 372 98


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>