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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

At 7 months of age, an infant with Lowe's oculocerebrorenal syndrome developed an epimacular membrane after three intraocular surgeries in the right eye. Serial fundus photographs document the membrane's appearance 6 months after lensectomy/vitrectomy for a dense cataract and 2 months after the second trabeculotomy for congenital glaucoma. Epimacular membranes are a vitreoretinal disorder found almost exclusively in adults. To the best of our knowledge, this is the first documented case of acquired preretinal macular membrane in an infant and the youngest case reported in the literature. The loss of formed vitreous and repeated deposition of blood products into the vitreous cavity may be responsible for the development of this preretinal membrane.
J Pediatr Ophthalmol Strabismus
PMID:Acquired epimacular membrane after multiple intraocular procedures in an infant. 341 24

Goniotomy is a safe effective procedure in isolated trabeculodysgenesis occurring in children under the age of two years, and is preferred by the authors in all such cases when visibility allows. It may also be effective for varying periods of time in Sturge-Weber syndrome, Aniridia, Axenfeld's syndrome, and Lowe's syndrome when these occur in infancy. Trabeculotomy is generally preferred in children with trabeculodysgenesis over the age of three years, in situations where corneal clouding prevents adequate visualization of the trabecular meshwork, and in patients with aniridia. In the latter group, although goniotomy can be effective, its success rate is low. The absence of iris covering the lens does increase the risk of lenticular injury and, therefore, trabeculotomy is usually chosen.
J Pediatr Ophthalmol Strabismus
PMID:Goniotomy vs trabeculotomy. 647 Sep 12

We studied the eyes of a 13-year-old boy with Lowe syndrome and updated the microscopic ocular findings. These are interpreted as a mesoectodermal dysgenesis involving the anterior and posterior segment. The eye exhibits a greater variety of morphologic change than any other organ in Lowe syndrome. The microscopic findings, particularly in the lens, are highly suggestive of this disorder. The pathogenesis of the ocular and extraocular lesions in Lowe syndrome in unknown. Most of the ocular abnormalities are probably determined in the first two months of gestation and there is no apparent embryologic relation to extraocular abnormalities. Some manifestations of Lowe syndrome may be secondary to accumulation of polyamines, a class of compounds that includes cytotoxic byproducts of faulty dibasic amino acid metabolism.
J Pediatr Ophthalmol Strabismus
PMID:Pathological features of the eye in the oculocerebrorenal (Lowe) syndrome. 726 55

We describe a 3-year-old boy with Lowe syndrome who previously underwent bilateral cataract surgery with intraocular lens implantation and strabismus surgery and developed an inferior corneal keloid. The lesion was resected. We report the results of immunohistochemistry analysis of the specimen, as well as alternative treatment modalities for this rare condition.
J Pediatr Ophthalmol Strabismus
PMID:Corneal keloid in Lowe syndrome. 1625 Feb 22