Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author describes the phenomenon of convergent squint and ptosis of the upper eyelid caused by relasping herpetic keratitis have not been previously reported, although this possibility should be considered. This observation represents a contribution to the better understanding of herpetic eye disease in general as well as the eventual recognition of the toxic effect of the HSH virus on man in vivo. According to the author these ocular disturbances are provoked by the toxic effect of the human herpes simplex virus and are connected to its neurotropism.
 ...
PMID:[Herpetic keratitis as a cause of disturbance of motility of the globe and upper lid (author's transl)]. 14 83

Neonatal infection with herpes simplex virus is, in recent years, a more frequently recognized complication of maternal genital herpes infection. Chorioretinitis has been described in approximately 16 cases. A case report is presented in which clinical photographs of the intraocular lesions are presented.
J Pediatr Ophthalmol Strabismus
PMID:Pan uveitis and retinitis in neonatal herpes simplex infection. 22 Apr 3

Five patients who had had neonatal herpes simplex virus infection were re-examined at ages that varied from 6 to 9 years. In all of them the diagnosis had been supported by virus isolation and antibody titration, and herpes virus type 2, the genital strain, had been the causative agent. Only 1 of the patients was mentally retarded. Three of the patients had manifest squint, and only 1 patient had normal visual acuity in both eyes. The fundus changes varied from atrophy of the retinal pigment epithelium in 3 patients to atrophy of the optic disc in 2 eyes and extreme tortuosity of the retinal arterioles and veins in 1 patient. One patient developed bilateral retinitis with exudation into the vitreous at the age of 5 years. Fluorescein angiography of this patient showed peripheral vascular closure and preretinal neovascularisation, with leakage in both eyes. This may have been due to chronic retinal vasculitis; haemorrhagic infarction may have induced the damage to retinal tissues. Laser photocogulation resulted in slight improvement of the visual acuity, clearing of the vitreous, and decrease of the fluorescein leakage.
 ...
PMID:Late ocular manifestations in neonatal herpes simplex infection. 92 25

There is a new trend in the US government's perception regarding health care today. It involves an increased awareness of how disease can be prevented and health promoted. The US government is supporting this concept with its Healthy People 2000 project. Specific pediatric concerns about health promotion and disease prevention in ophthalmology include amblyopia and strabismus, ophthalmia neonatorum, ocular trauma, radiation injury, xerophthalmia, herpes simplex, herpes zoster, infections and metabolic and genetic disorders. Adult health promotion/disease prevention priorities include glaucoma; trauma; diabetic retinopathy; corneal problems; iatrogenic infections; exposure keratitis; ocular toxicity from drugs, chemicals, and the environment; visual loss from neglect; and those mentioned in the pediatric area.
 ...
PMID:Health promotion and disease prevention in ophthalmology. 221 91

A total of 136 injections was given to 83 patients for strabismus (99 injections), blepharospasm (29 injections), and spastic entropion (eight injections). All four patients with entropion experienced temporary benefits and early recurrence; one injection resulted in temporary paralytic ectropion. Two of 13 patients treated for blepharospasm developed transient bilateral blepharoptosis. Temporary and related sequelae of extraocular muscle injection included one periocular hemorrhage, one total ophthalmoplegia, and a 44% incidence (29 of 66 patients) of blepharoptosis, which in two patients lasted more than six months. Within three days of injection one patient developed homolateral acute herpes simplex keratitis and a second died of an acute myocardial infarction. No causal relationship for these events has been established.
 ...
PMID:Sequelae of botulinum toxin injection. 402 71

The disappearance of the anterior vascular capsule of the lens (tunica vasculosa lentis) in the preterm infant has been established to be useful in accurately estimating gestational age between the twenty-seventh and thirty-fourth weeks in infants appropriate or small for gestational age. Six infants have been studied with abnormalities of the anterior vascular capsule of the lens in which congenital TORCH infection has been documented (1 toxoplasmosis, 2 rubella, 2 cytomegalovirus, and 1 herpes simplex virus). Since the anterior vascular capsule generally atrophies symmetrically and completely after the thirty-fourth week of gestation, the findings of marked asymmetry and/or persistence and hypertrophy of the anterior vascular capsule of the lens warrants initiation of TORCH studies in the newborn infant.
J Pediatr Ophthalmol Strabismus
PMID:Examination of the anterior vascular capsule of the lens: III. Abnormalities in infants with congenital infection. 626 58

Acute retinal necrosis in children is a devastating disease that requires early diagnosis and treatment. The authors describe a rarely reported case of bilateral acute retinal necrosis in a child caused by neonatal herpes simplex virus type 2, where the presence of previous chorioretinal scarring made diagnosis challenging.
J Pediatr Ophthalmol Strabismus
PMID:Acute retinal necrosis secondary to herpes simplex virus type 2 with preexisting chorioretinal scarring. 1828 69