Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this paper is to determine the value of overcorrecting minus lenses in treating children with intermittent exotropia. The aim with this therapy is to secure an increase in the quality of fusion and to induce a quantitative decrease in the angle of strabismus. Thirty-five children were treated with 2.00 to 4.00 diopters of overcorrecting minus lenses for a median of 18 months duration. Of these, 46% had an improved quality of fusion during therapy; 26% had an improved quality of fusion and also had a quantitative decrease in their angle of deviation; and 28% had an inadequate improvement in their quality of fusion and decrease in the angle of their deviation with this therapy. Two children went from intermittent exotropia to esotropia while wearing their minus lenses--both had high accommodative-convergence/accommodation ratios (11.5 delta/1D and 10.7 delta/1D). Seventy percent of good responders who were followed for at least 1 year after discontinuing the therapy maintained a qualitative or quantitative improvement in their intermittent exotropia.
 ...
PMID:Overcorrecting minus lens therapy for treatment of intermittent exotropia. 665 90

Temporal modulation sensitivity functions were investigated by behavioral methods in two monkeys reared with normal visual experience and 12 monkeys reared with abnormal early visual experience. Experimental treatments were initiated when the animals were approximately one month of age. Two monkeys were each treated with one of the following procedures: (1) long-term monocular lid suture, (2) short-term monocular lid suture, (3) surgically induced esotropia, (4) surgically induced exotropia, (5) optical dissociation of binocular vision with ophthalmic prisms, or (6) chronic monocular cycloplegia. The temporal modulation sensitivity functions for uniform field flicker for both eyes of the control subjects and for the untreated eyes of the experimental subjects were similar to functions for humans measured on the same apparatus using the same behavioral procedures. All eight of the monkeys preconditioned by lid suture or surgically induced strabismus showed reduced sensitivity at all temporal frequencies with the difference between the experimental and control eyes being larger for the high than low temporal frequencies. The monkeys reared with optical dissociation of binocular vision or chronic monocular cycloplegia showed equal temporal modulation sensitivities of the two eyes, but failed to show binocular summation. It was concluded from these studies that abnormal early visual experience in monkeys results in deficiencies in the processing of both spatial and temporal information, but the differences between the treated and untreated eyes were usually greater in the spatial domain than the temporal domain.
 ...
PMID:Behavioral studies on the effect of abnormal early visual experience in monkeys: temporal modulation sensitivity. 666 52

The results of conventional strabismus surgery are always somewhat uncertain, despite the most careful preoperative assessment. Yet it is important to achieve good alignment in patients with fusion potential who have intermittent exotropia, extraocular muscle paresis or a restrictive syndrome. Planning surgery for patients with thyroid myopathy and planning reoperations is particularly difficult. In 30 patients with various strabismus disorders the use of adjustable sutures proved safe and of value; the results were unacceptable in only 5 of the 28 patients with horizontal deviations. The inconvenience for the surgeon and the extra discomfort for the patient seemed outweighed by the predictability of the surgical result.
 ...
PMID:Adjustable sutures in strabismus surgery. 675 11

The purpose of this study was to review the literature pertaining to non-surgical cure rates for strabismus published since 1958 and compare it to Flom's prognostic model. However, no studies were found that could be compared directly to Flom's model. One reason for this was due to the use of different definitions of a cure by different clinicians. Another reason was the failure to categorize the data according to the effect that retinal correspondence, frequency, and direction of the deviation had on the cure rates. From the studies which specified Flom's functional cure or its equivalent, it was determined that strabismic cure rates could be broken down as follows: Constant esotropia-29%; Intermittent esotropia-73% Constant exotropia-53%; Intermittent exotropia-62% Suggestions were made for the reporting of data to make future research more comparable and useful to the practitioner.
 ...
PMID:Success in strabismus therapy: a literature review. 675 60

A perimeter and a modified Lees screen were used to determine the area of visual field that is suppressed in strabismus. Strabismic patients without fusion suppress the whole area of the visual field of the deviating eye that could have correspondence with the dominant eye. In the monofixation syndrome, suppression only involves the fovea and the diplopic point of the deviating eye. Diplopia, if present, is appreciated throughout the visual field shared by the two eyes, except for the blind spots. No evidence of hemiretinal suppression was found in any type of horizontal strabismus, including exotropia. However, there is a hemiretinal trigger mechanism for suppression. Once suppression has been triggered by this mechanism, it involves the whole visual field of the deviating eye, except for the monocular temporal crescent.
 ...
PMID:Suppression in strabismus and the hemiretinal trigger mechanism. 682 65

Criteria for defining congenital esotropia and its cure are related to a documented case history. A congenitally esotropic child had strabismus surgery at age 13 months. At 11 years of age the had 20 delta of left exotropia. One year of vision training enabled her to achieve some stereopsis but she retained a small angle asotropia whenever the controlled her exophoric tendency.
 ...
PMID:Congenital esotropia--a documented case report. 714 76

A critical review is made of the literature on binocular perimetry in strabismus. A broad range of results was obtained by various authors, because different testing techniques were used. The concept of sensory testing of strabismic patients in casual seeing condition should be introduced also into binocular perimetry. Therefore a series of experiments is presented in which patients with small-angle comitant strabismus were tested. It was shown that: a) in small-angle esotropia the areas of single vision previously thought to be due to suppression are, instead, areas of binocular vision sustained by anomalous retinal correspondence (ARC); b) this can be seen only when using fusable stimuli as test targets; c) no suppression scotomas were found in patients with small-angle strabismus in the whole visual field; d) appropriate control-marks for binocularity are necessary, i.e. monocularly presented items. They influence the results, as well e) the area of binocular single vision in strabismus (called pseudo-Panum's area) is wider than the Panum's area of normals. Moreover it is easier to disrupt binocular cooperation sustained by ARC causing diplopia than binocular cooperation in normals; f) ARC seems to be more deeply rooted in the center than in the periphery of the visual field; g) superimposable findings were obtained in small-angle constant exotropia; h) in large-angle exotropia wide suppression scotomas were found, which often override the midline. Hemianopic suppression scotomas in exotropia can be found only when 'dissociating' testing techniques are used; i) the same group of patients with small-angle esotropia was examined with the author's technique and with the classical method proposed by Harms. The results were strongly dependent on the method used and the same patient responded differently to the two tests. It is concluded that in small-angle strabismus there is an anomalous type of binocular single vision, which can be tested with binocular visual field techniques. This binocularity can only be found when non-artificial testing conditions are used. The usefulness of this anomalous binocular vision in the every day seeing condition of the patient is discussed.
 ...
PMID:Binocularity in comitant strabismus: binocular visual fields studies. 715 59

A 7-year-old child underwent craniotomy for a craniopharyngioma. One month later she developed a divergence excess type exotropia and had strabismus surgery 11 months later. The day after strabismus surgery, the parents noted abnormal eye movements that represented see-saw nystagmus. The patient had a small esotropia after surgery, but it was found that stimulated convergence controlled the nystagmus. This case illustrates the dual central and ocular influence on the development of see-saw nystagmus.
J Pediatr Ophthalmol Strabismus
PMID:See-saw nystagmus after strabismus surgery. 715 22

A nine-week-old Caucasian male presented with right ptosis and right exotropia due to a third cranial nerve palsy. Symmetrical macular lesions and a paramacular hyperpigmented lesion with overlying vitreous cells in the left eye were compatible with congenital toxoplasmosis. Computer tomography demonstrated calcifications in the periventricular and midbrain regions where the oculomotor nerve exits the brainstem. The diagnosis was confirmed by the toxoplasma indirect fluorescent antibody titer greater than 1:2048 for the infant and greater than 1:512 for the mother. Treatment was instituted with pyrimethamine, sulfadiazine and folinic acid. Neurologic sequelae included a right hemiparesis, infantile seizures, and generalized developmental delay. A Mueller's muscle resection (RUL) combined with 9-mm recession of the right lateral rectus and 7-mm resection of the right medial rectus muscles produced minimal ptosis and right exotropia one year later. the child now prefers to fix with the right eye and a vertical nystagmus is evident in the left eye. To our knowledge this is the first reported case of an infant with noncomitant strabismus due to congenital toxoplasma cranial nerve involvement. The finding of an acquired third cranial nerve palsy accompanied by progressive neurologic sequelae warrants consideration of congenital toxoplasmosis.
J Pediatr Ophthalmol Strabismus
PMID:Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy. 717 24

In summary, 22 patients have been presented who have undergone lateral rectus recessions ranging from 8 to 14 millimeters. The overall cosmetic success rate (plus or minus 15 diopters of orthophoria) was 77%. Eight of these patients had unilateral recession-resection procedures. Surgically created incomitance ranged from 3 millimeters to 6 millimeters and correlated only poorly with the amount of surgery performed. None of the patients complained of cosmetic or symptomatic effects of the lateral incomitancy induced. We have restricted surgery of the large angle exotrope to a single, two-muscle procedure, thereby decreasing patient morbidity. It is therefore our recommendation that surgery for large angle exotropia be restricted to two horizontal muscles.
J Pediatr Ophthalmol Strabismus
PMID:Surgery of large angle exotropia. 720 15


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>