Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over a six-year period, between 1984 and 1990, 622 patients with basal cell and squamous cell carcinoma of the eyelids were examined at our institution. Thirteen patients had orbital invasion at initial examination. The average age of patients at orbital invasion was 75.8 years. Ten patients were men, eight of whom had basal cell carcinoma and two of whom had squamous cell carcinoma. Most patients had an orbital mass and incomitant strabismus at initial examination. Invasive basal cell carcinoma developed in 11 patients, and squamous cell carcinoma developed in two patients. Ten patients were treated for cutaneous carcinoma at the site of invasion before examination at our institution. The average duration between onset of a cutaneous lesion and our examination for orbital invasion was 9.8 years for basal cell carcinoma and one year for squamous cell carcinoma. Radiologic and histopathologic features were reviewed. The clinical characteristics of these patients were reviewed and orbital exenteration was recommended to all 13 patients. Nine patients underwent exenteration and four refused the operation.
 ...
PMID:Clinical characteristics associated with orbital invasion of cutaneous basal cell and squamous cell tumors of the eyelid. 155 Jan 79

There are many potential complications which have been reported in association with the naevoid basal cell carcinoma syndrome. We have been able to show the relative frequencies of these problems in a population based study of 84 cases in the north west of England. The major complications of basal cell carcinomas and jaw cysts occur in over 90% of patients by 40 years of age, but may both occur before 10 years of age. Less well described complications are ovarian calcification or fibroma (24%), medulloblastoma (5%), cardiac fibroma (3%), cleft palate (5%), and ophthalmic abnormalities such as squint or cataract (26%). This study more clearly defines the possible complications of the syndrome and gives clearer guidelines for counselling and screening affected and at risk persons.
 ...
PMID:Complications of the naevoid basal cell carcinoma syndrome: results of a population based study. 832 88

Basal cell carcinoma is rare in children and usually is associated with genetic or immune predisposing factors. A 14-year-old otherwise healthy boy who had an eyelid basal cell carcinoma is presented. The tumor was in the subcilliary area in the lateral part of the lower eyelid, was ulceronodular with some pigmentation, and had grown over the past 6 months. The patient's medical history was unremarkable. Systemic and immunologic studies did not find any abnormality that could present a predisposition to skin cancer. The tumor was excised and the resulting eyelid defect was repaired with a semicircular flap. During a follow-up period of 44 months, the patient did not develop any recurrence, de novo tumor, or extraocular disease of any significance.
J Pediatr Ophthalmol Strabismus 2014 Dec 12
PMID:Eyelid Basal cell carcinoma in a healthy child. 2549 Feb 39