Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four boys with facial-digital-genital or Aarskog syndrome were whort with triangular faces, characteristic deformities of the hands and feet, and anomalies of the external genitalia. The syndrome appears to be inherited in an X-chromosomes-limked recessive manner. Previous reports emphasized the presence of hypertelorism but careful measurements of the interorbital dimensions revealed primary telecanthus in addition to hypertelorism. The palpebral fissures had a marked antimongoloid obliquity and in half the reported cases, there was unilateral or bilateral congenital blepharoptosis. Strabismus, hyperopic astigmatism, and large corneas may be additional features.
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PMID:Ophthalmic manifestations of Aarskog (facial-digital-genital) syndrome. 23 44

Although reading ability is known to be related to a large number of factors, when a child having a reading problem is brought to an optometrist he (or she) has the responsibility of determining whether or not a visual anomaly may be a major or contributing cause of the reading problem. A review of the literature indicates that myopia is consistently associated with good reading performance; and that hypermetropia, astigmatism, lateral phorias, poor fusional vergences, strabismus and color vision anomalies tend to be associated with poorer than average reading performance. Well-designed and well-controlled studies are needed, particularly concerning the effect on reading ability of the correction of visual anomalies. Until such studies have been done, any child who has a reading problem deserves a thorough optometric or ophthalmologic examination and the correction of any visual anomalies found.
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PMID:Are visual anomalies related to reading ability? 30 32

215 preschool siblings of children presenting with squint/amblyopia were screened by refraction after cycloplegia. The presence of +2.00 or more D of spherical hypermetropia in both eyes, or +1.00 or more D sphere or cylinder of anisometropia was significantly associated (P=0.0779%) with that child being identified 2+ years later as having either squint or amblyopia or both. Astigmatism of +1.50 or more D in either eye was significantly associated with anisometropia (P=0.000 0013%). If bilateral hypermetropia of +2.00 or more DS and/or +1.50 or more D of astigmatism in either eye had been taken as criteria for abnormality (ignoring anisometropia), there was a more significant association (P=0.0025%) between refraction and squint/amblyopia in these siblings. Such a child had 4 times more chance of having a visual defect than one who had no error of refraction when screened. These findings suggest that an environmental factor such as blurred vision may be relatively more important as a cause of squint/amblyopia than a genetically determined neurological abnormality.
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PMID:Refraction as a means of predicting squint or amblyopia in preschool siblings of children known to have these defects. 43 40

Cycloplegic refraction of 1-year-old children is technically possible and is acceptable to mothers as a method for screening children for visual defects. The range of refractions found in a sample of 186 1-year-old children is reported. Prediction of which children are significantly at risk for squint and/or amblyopia is possible on the basis of refractions at age 1 year according to the criteria selected for an 'abnormal' refraction. Bilateral hypermetropia and/or astigmatism or anisometropia at age 1 year was significantly (P less than 1 in 10 000) associated with a child eventually being found to have squint or amblyopia. Both the age of screening and criteria of abnormality will probably need modification. +2.50 or more D hypermetropia in any one meridian of either eye at age 1 year was even more significantly (P = 0.000 000 05%) associated with squint and/or amblyopia. The possibility that meridional hypermetropia could be the basic defect in squint and amblyopia is discussed.
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PMID:Screening for refractive errors at age 1 year: a pilot study. 43 41

Amblyopia is one of the most common eye ailments in children. Early treatment can frequently eliminate this problem. The responsibility for early recognition falls primarily on the pediatrician. The following summarizes what ought to be done for each age group to rule out amblyopia and its associated condition. Newborn to age four months. Make sure the eyes appear normal externally and have a clear red reflex (no cataracts). Infants after age four months. Check fixation with each eye with a penlight. Check for symmetrical corneal light reflexes. Also check red reflex and fundus. Age two to four years. Be particularly aware of any family history of strabismus or amblyopia. The examination should include an observation of the fixation pattern with each eye, the symmetry of the corneal light reflex, and an evaluation of the fundus and the red reflex. Age four. Visual acuity in each eye should be measured. Ideally, all children should be referred for a complete eye examination and refraction if this is economically feasible. School age. Check vision yearly. If a person is going to have one complete routine eye examination by an ophthalmologist in the first half of his lifetime, checking him at age four would be ideal. It should include a cycloplegic refraction to tule out excessive farsightedness, nearsightedness, astigmatism, or unequal refraction in the two eyes. This should be done by a person thoroughly schooled in recognizing eye diseases rather than by a nonmedical practitioner. Annual eye examinations by an ophthalmologist are probably unnecessary if visual acuity is good and the child is asymptomatic.
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PMID:Amblyopia and the pediatrician. 83 82

A 4-year-old boy with uncorrected anisometropic indirect astigmatism showed amblyopia and strabismus. Over a period of approximately 3 yr, neutralization of the refractive error and treatment of the amblyopia and strabismus resulted in single binocular vision with good stereopsis. The results suggest that at least up to age 7 the visual system is sufficiently plastic to be modified by treatment.
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PMID:Early treatment of anisometropic astigmatism and strabismus. 93 Oct 15

If it is necessary to prescribe contact lenses for children, this correction should be made as soon as possible. As a consequence of the development of soft (hydrophile) lenses, the above mentioned group of patients has increased considerably. In any case, a monolateral aphakia as well as a manifest anisometropia should be corrected by a contact lense to avoid amblyopia, heterotropia and loss of stereoscopic vision. Usually soft lenses are well tolerated, so that patients suffering from aphakia as well as hyperopia should always use this type of lense. Nevertheless, the hard lense still has its indication in treating myopia and high astigmatism.
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PMID:[Contact lenses for children. Indications and results]. 96 5

A case of congenital strabismus fixus divergens is described. Other anomalies were vertically oval corneas, high mixed astigmatism, amblyopia, horizontal nystagmus, microcephaly, maxillary hypoplasia, micrognathia, low set large ears, and hyperostosis frontalis interna.
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PMID:Strabismus fixus divergens and associated craniofacial anomalies. 107 37

A cohort of infants of birthweight < or = 1700 g studied prospectively for retinopathy of prematurity (ROP) has been reviewed at 6 months corrected age and the findings related to the neonatal data. The overall incidence of strabismus was 6.4% (30/468), rising from 3.1% (7/229) without ROP to 29.2% (7/24) with stage 3. Strabismus and fusional ability were significantly related to presence and severity of ROP, and abnormal neonatal cranial ultrasound findings. Binocular visual acuity was measured in 340 infants between 20 and 40 weeks corrected age. Eight were subnormal, all due to neurological problems. For the remainder, despite falling within the normal range, there was a significant trend (p < 0.001) for lower acuities with increasing ROP severity. Cycloplegic refraction on 387 infants revealed, with increasing ROP severity: 1, a significant trend towards myopia; 2, increased magnitude of astigmatism; 3, alteration of the astigmatic axis; 4, increased incidence of anisometropia. For the first three categories there was an insignificant trend between no ROP and stage 2, reaching significance only between stage 2 and 3. The predominant axis of astigmatism in infants without ROP was between 60 degrees and 120 degrees, but with ROP there was a significant trend away from this direction.
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PMID:Retinopathy of prematurity: a prospective study. Review at six months. 128 10

The refractive changes in 84 children (155 eyes) following horizontal strabismus surgery and in 97 children (181 eyes) without surgical intervention were studied. The results indicated that the spherical refraction and axis of astigmatism were not significantly affected by the operation, especially when both recession and resection were done on the same eye; however, the cylindrical refraction changed markedly within 6 weeks of surgery. These changes would be minimized and become stable 6 weeks after the operation, suggesting that the proper time for a cycloplegic refraction was 6 weeks after a horizontal strabismus surgery.
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PMID:[The effect of horizontal strabismus surgery on the refractive status in children]. 142 43


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