Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038379 (strabismus)
 9,317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 11-year follow-up of a child presenting with Paget's disease of bone, and who subsequently developed pseudoxanthoma elasticum, is described. The influence of therapy on the ocular manifestations was disappointing. Calcitonin did not prevent the occurrence or progression of angioid streaks, and Argon laser photocoagulation of complicating subretinal neovascular membranes failed to prevent visual loss.
J Pediatr Ophthalmol Strabismus
PMID:Visual impairment in a case of juvenile Paget's disease with pseudoxanthoma elasticum: an eleven year follow up. 262 50

The ocular findings in two patients with Chronic Familial Hyperphosphatasemia are described in detail. They consist mainly of abnormal pigmentation, the presence of retinal folds of variable degree, and angioid streaks. It is suggested that these changes are in relationship to abnormal collagen metabolism and that CHF is not only a bone dysplasia but a more generalized condition with variable extraskeletal manifestations.
J Pediatr Ophthalmol Strabismus
PMID:Ocular abnormalities in chronic familial hyperphosphatasemia. 625 Nov 95

Unilateral angioid streaks of the ocular fundus with homolateral ocular melanocytosis in a 49-year-old white woman are reported. The findings are substantiated by fluorescein angiography. The local changes related to ocular melanocytosis probably precipitated the formation of angioid streaks in the genetically predisposed patient. Two greyish-yellow patches were also found on ophthalmoscopy of the involved eye. One of these, located in the paramacular region, exhibited definite progression, and transformed into a disciform lesion without implicating the macula. The presence of these likely precursors of angioid streaks about the macula is more ominous. A comment about the relationship between melanocytosis, angioid streaks, and phakomatoses is added.
J Pediatr Ophthalmol Strabismus
PMID:Ocular melanocytosis and angioid streaks. 744 38