Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By means of a new type of microinjection apparatus, which has a micropipette located in a hole through the optical axis of the condenser lens, we injected interferon (IFN) or 2',5'-oligoadenylate (2-5A) into mouse L cells, and observed their antiviral effects on the multiplication of vesicular stomatitis virus (VSV). After injection, cells were infected with VSV, and labeled with [3H]uridine in the presence of actinomycin D. The proportion of cells infected with VSV which carried radioactive virus-RNA was determined by autoradiography. IFN introduced directly into L cells had no effect on the virus growth. This result supports the idea that IFN molecules exert their effect from outside the cell membrane without penetrating into the cytoplasm. 2-5A, on the other hand, was able to inhibit the growth of VSV effectively when injected into L cells. The antiviral effect was dependent on the dose of 2-5A injected, and moreover the effect was transient, since it disappeared completely after 24-h incubation.
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PMID:Microinjection of interferon and 2',5'-oligoadenylate into mouse L cells and their effects on virus growth. 618 Oct 54

We studied the effects of three forest types on multiple factors that are believed to influence the transmission of the New Jersey serotype of vesicular stomatitis (VSNJ) virus on Ossabaw Island, GA. These factors included availability of tree hole diurnal resting habitat for the presumed sand fly vector, Lutzomyia shannoni Dyar; relative abundance of L. shannoni; prevalence of VSNJ virus infection in sand flies; and prevalence of VSNJ virus antibodies in wild swine. Tree hole availability, sand fly abundance, and antibody prevalence in swine were significantly greater in maritime live oak forest than in other forest types. A single isolate of VSNJ virus was obtained from sand flies collected in maritime live oak forest. These data indicate that the relative abundance of adult L. shannoni is influenced significantly by the availability of tree holes and that VSNJ virus infection in wild swine is linked to forest type and is greatest in areas capable of supporting abundant populations of L. shannoni.
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PMID:Effect of forest type on the distribution of Lutzomyia shannoni (Diptera: Psychodidae) and vesicular stomatitis virus on Ossabaw Island, Georgia. 838 77