Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038362 (
stomatitis
)
8,852
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kethoxal bis (thiosemicarbazone) (
KTS
) inhibited replication of, and plaque formation by, vesicular
stomatitis
virus (VSV) in chick embryo cells. No other thiosemicarbazones tested were effective. Virus-specific m-RNA and protein synthesis were inhibited by
KTS
. However, virion RNA-dependent RNA synthesis was not inhibited by the drug. Treatment of VSV virions directly with
KTS
produced enhancement, rather than inactivation, of plaque formation.
KTS
inhibited cellular DNA and RNA synthesis by 67 and 25% respectively. Since cellular DNA and RNA synthesis are not required for VSV replication, the inhibition of these processes is probably unrelated to the antivirial activity of
KTS
. Cellular protein synthesis was inhibited 24% by
KTS
. Unexpectedly, synthesis of four proteins was induced in
KTS
-treated uninfected cells.
...
PMID:Inhibition of vesicular stomatitis virus by kethoxal bis (thiosemicarbazone). 7 31
