Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038362 (
stomatitis
)
8,852
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
MOV10
has emerged as an important host antiviral factor.
MOV10
not only inhibits various viruses, including human immunodeficiency virus type 1, hepatitis C virus and vesicular
stomatitis
virus, but also restricts the activity of retroelements long interspersed nucleotide element-1, Alu, SVA and intracisternal A particles. Here, we report that
MOV10
suppresses influenza A virus infection through interacting with viral nucleoprotein (NP), sequestering viral RNP in the cytoplasm and causing the degradation of viral vRNA. The antiviral activity of
MOV10
depends on the integrity of P-bodies. We also found that the antiviral activity of
MOV10
is partially countered by viral NS1 protein that interferes with the interaction of
MOV10
with viral NP and causes
MOV10
degradation through the lysosomal pathway. Moreover, NS1-defective influenza A virus is more susceptible to
MOV10
restriction. Our data not only expand the antiviral spectrum of
MOV10
but also reveal the NS1 protein as the first viral antagonist of
MOV10
.
...
PMID:MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein. 3091 67
